Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"FGFR"”.
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Mechanisms Underlying Distinct Egfr Versus Fgfr-3 and -1 Dependency In Human Bladder Cancer Cells
… (EGFR) and fibroblast growth factor receptor (FGFR) are activated by gene amplification, mutation and overexpression in bladder cancer, which drives tumor development and progression. Both EGFR and FGFR inhibitors are currently being tested in clinical trials. However, bladder cancer (BC) cells …
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Gene Expression in mESC Deficient in FGFR Signalling and the Identification of the Novel Gene Ened
… growth factors (FGFs) and their receptors (FGFRs) have been shown to be important during early embryogenesis. Previously it has been shown that ESCs expressing a mutant form of FGFR failed to form the two characteristic cell layers of EBs: the endoderm and the ectoderm. In addition, due to …
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FGF signaling in Xenopus laevis lens regeneration
… First, the mRNA expression levels of FGFs and FGFRs in the cornea and retina were observed, as the key ligand from the retina travels to the cornea to interact with its receptor and trigger lens regeneration. The described experiments found that FGF1, FGF8, and FGF9 mRNA are more expressed in …
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Investigating fibroblast growth factor and its role in canine osteosarcoma
… with fibroblast growth factor receptors (FGFRs) to initiate cell signaling that is important in embryonic development, wound healing, and angiogenesis. FGF2, also termed basic FGF (bFGF), plays an important role in osteoblast proliferation and maintaining osteoblasts in an undifferentiated …
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Expression and Purification of Unlabelled and Isotopically Labelled Human Fibroblast Growth Factor-1 and its Receptor Relevance in Cancer Research
… with fibroblast growth factor receptors (FGFR) and are a potent target in cancer. In this study, we report an efficient affinity column purification of hFGF-1 and the D2 domain of FGFR-2 from bacterial expression followed by SDSPAGE analysis. Steady state fluorescence results showed that …
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The Role of Acidic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor 4 In High Grade Serous Carcinoma
… value of fibroblast growth receptor 4 (<em>FGFR4</em>), another candidate gene of the FGF/FGFR axis located in the same amplicon. The emphasis will be delineating the role the FGF1/FGFR4 signaling axis plays in high grade serous ovarian carcinoma; and test the feasibility of targeting the …
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Glycosaminoglycan-protein interactions : the fibroblast growth factor paradigm
… been proposed to account for the mode of FGF-FGFR interactions and the role of HSGAGs in modulating FGF2 signaling. It was hypothesized that one role played by HSGAGs was to stabilize FGF2 oligomers in a "side-by-side" or cis fashion for presentation to fibroblast growth factor receptor …
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Identification of novel components in fibroblast growth factor signalling
… The goal of this project was to identify novel FGFR1 interacting proteins. The strategy employed for mapping novel partners on the basis of peptide-protein interaction was peptide pull-down. Using synthetic pairs of phosphorylated and unphosphorylated peptides, pull down experiments were …
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Neuroprotective Effects of FGF20 on Dopamine Neurones
… receptors (fibroblast growth factor receptor (FGFR) 1,3, and 4) were demonstrated to be localised to dopamine neurones and glial cells in the rat nigrostriatal tract and in VM embryonic dopamine neurone cultures. In vitro, FGF20 protected VM embryonic dopamine neurones against 6OHDA toxicity, …
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Συστηματική ανασκόπηση: αποτελεσματικότητα και ασφάλεια των αναστολέων κινάσης τυροσίνης στο χολαγγειοκαρκίνωμα / Efficacy and safety of tyrosine kinase inhibitors in cholangiocarcinoma: a comprehensive systematic review
… διαλογής συμπεριλήφθηκαν 27 μελέτες. Οι FGFR-στοχευμένοι TKIs σε μοριακά επιλεγμένους πληθυσμούς αφορούσαν μονοθεραπείες και εμφάνισαν διάμεση OS 12,2–25,8 μήνες και ORR από 15,6% έως 50%. Αντίθετα οι VEGFR/multikinase (αντιαγγειογενετικοί) αναστολείς καθώς και οι EGFR στοχευμένοι …
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Relevance of Fgfr1 and Its Isoforms In Prostate Cancer Bone Metastases
<p>The fibroblast growth factor receptor (FGFR) 1 is implicated in prostate cancer (PCa) progression. Various FGFR1 isoforms have been described and we demonstrate here that the well-characterized FGFR1 a and b isoforms are correlated with the expression of different genes and pathways in human …
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Using Xenopus laevis to study the mechanisms governing the early germline development and the formation of vertebrate body plan
… translocation approach, where FGFR ICD is recruited from the cytoplasm to the plasma membrane by light, leading to its subsequent activation. This strategy results in optical activation of FGFR with low background activity and high sensitivity, which allows light-induced …
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Virtual Screening of Multi-Target Agents by Combinatorial Machine Learning Methods
… 4 dual-kinase inhibitors pairs (EGFR-Src, EGFR-FGFR, VEGFR-Lck, Src-Lck), I applied the COMBI-SVMs to the identification of dual-target antidepressant agents of 7 target combinations (serotonin transporter paired with noradrenaline transporter, H3 receptor, 5-HT1A receptor, 5-HT1B receptor, …
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Innovative Purification Protocol for Heparin Binding Proteins: Relevance in Biopharmaceutical and Biomedical Applications
… growth factors (FGFs) and its receptors (FGFRs). In this study, we report an efficient off-column purification of FGF-1 from soluble fractions and purification of the D2 domain of FGFR from insoluble inclusion bodies, using a weak amberlite cation (IRC) exchanger. This approach is an …
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Discovery and Elucidation of The Fgfr3-Tacc3 Recurrent Fusion In Glioblastoma
… growth factor receptor 3</em> (<em>FGFR3</em>) gene to the<em> transforming coiled-coil containing protein 3 </em>(<em>TACC3</em>) gene in glioblastoma multiforme. The fusion occurred in 8.3% of patient samples, but not in low grade or normal samples. <em>FGFR3-TACC3 </em>produced an …
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Signalling and transcriptional regulation of human primordial germ cell specification
… I found that inhibition of FGF receptor (FGFR) or its downstream effectors (MEK and PI3K) enhanced competency for PGC fate. By contrast, premature MEK/ERK activation in hESCs resulted in aberrant expression of endoderm markers and loss of germ cell potential. Altogether the study showed …
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Glycomics : an emerging paradigm to protein-carbohydrate interactions
… FGF-HSGAG interactions and FGF-receptor (FGFR) interactions which collectively influence the specificity of HSGAG mediated FGF signaling. 2. The second part focuses on developing enzymatic tools for analysis of GAGs using chondroitinase B, HSGAG 2-0 sulfatase and 3-0 sulfotransferase as …
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Understanding and Targeting the FGF-2/S6K2 Signal Pathway in Small Cell Lung Cancer Towards the Development of Novel Anti-Cancer Treatments.
… receptor, Fibroblast Growth Factor Receptor 1 (FGFR-1). Downstream of receptor activation a signal complex forms consisting of three kinases – B-Raf, Protein Kinase C epsilon (PKCε) and Ribosomal S6 Kinase Beta II (S6K2) – resulting in the activation of the latter. S6K2 then phosphorylates the …
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Engineering Fluorescently Labeled Human Fibroblast Growth Factor One Mutants and Characterizing Their Photophysics Properties Towards Designing FRET Assays
… healing occurs when hFGF1 binds to its receptor (FGFR). However, when heterogenous homeostasis is not maintained, fibroblast cells exhibit excessive proliferation which can lead to a myriad of cancers. smFRET is an ultrasensitive distant dependent (1-10 nm) technique capable of resolving such …
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Molecular Genetic Analysis of FGF23 Bioactivity in the Bone-Kidney Endocrine Axis
… a signaling complex composed of Klotho and an FGFR for bioactivity, however, the location and composition of the signaling complex is unknown. Klotho localizes to the renal distal convoluted tubule, whereas the sodium phosphate co-transporters are expressed within the renal proximal tubules. …
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