Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"FGF23"”.
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Molecular Genetic Analysis of FGF23 Bioactivity in the Bone-Kidney Endocrine Axis
… rickets (ARHR). Fibroblast growth factor-23 (FGF23), identified as the causative gene in ADHR, is produced in bone and plays a central role in kidney phosphate regulation. Increased serum concentrations of FGF23 lead to renal phosphate wasting through down regulation of renal sodium-phosphate …
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Relación entre el factor de crecimiento fibroblástico 23 (fgf23) y el fenómeno inflamatorio en la enfermedad vascular aterosclerótica
… inflamación. En este sentido, la aparición del FGF23, además de promover una revisión en los modelos actuales del control del metabolismo mineral. El principal objetivo de esta tesis doctoral es la caracterización de la relación entre FGF23 y la enfermedad vascular aterosclerótica, así como sus …
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Metabolismo mineral en niños con deficiencia subclínica de vitamina D. Implicaciones del Factor de Crecimiento Fibroblástico 23 (FGF23).
… del factor de crecimiento fibroblástico 23 (FGF23) en las investigaciones relacionadas con la vrtamina D ha despertado el interés por evaluar este parámetro para ampliar la comprensión del metabolismo fosfocálcico en los niños. Esta tesis doctoral pretende arrojar luz sobre la fisiopatología …
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Τα επίπεδα του αυξητικού παράγοντα των ινοβλαστών 23 (FGF23) και της πρωτεΐνης Klotho σε σχέση με την ηλικία και τη νεφρική επαναρρόφηση φωσφόρου στην παιδική ηλικία
… Ο αυξητικός παράγοντας των ινοβλαστών 23 (FGF23) είναι μία φωσφατουρική ορμόνη που παίζει σημαντικό ρόλο στην ομοιόσταση φωσφόρου. Η πρωτεΐνη Klotho είναι ο συμπαράγοντας του FGF23 που μεσολαβεί τη σύνδεση του FGF23 στον υποδοχέα του. Στη βιβλιογραφία για τα υγιή παιδιά υπάρχουν λίγα …
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Clinical Diagnosis, Genetic Background and Treatment of Vitamin-D Resistant Hypophosphatemic Ricket
… to the increase of fibroblast growth factor 23 (FGF23). Excess FGF23 reduces renal phosphate reabsorption, hence hypophosphatemia, and consequentially diminishes the synthesis of active vitamin D. Treatment includes conventional therapy of phosphate and active vitamin D, together with correction …
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Riesgo vascular en el paciente alcohólico.
… de 16 meses. Encontramos niveles más altos de FGF23 en pacientes que en controles (Z=-3.941,p˂0.001). Además, los niveles de FGF23 (Z=5.302, p˂0.001), alpha klotho (Z=5.06 p˂ 0.001) y esclerostina (t=2.898, p=0.005) fueron mayores en pacientes cirróticos que en no cirróticos. Mediante análisis …
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Developmental signaling pathways in adult energy homeostasis
… FGFs, FGF19 (FGF15 in mice), FGF21, and FGF23 have well described roles in the regulation of metabolic processes in adults. While FGF23 is primarily involved in the regulation of phosphate and vitamin D homeostasis, FGF19 and FGF21 have shown similar pharmacological effects on whole body …
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The role of FGF growth factors in the development of chemotherapy drug resistance in ovarian cancer cells.
… protein expression for one of the FGF factors, FGF23, which was altered in A2780CBN and A2780CBNDXL resistant cell lines.
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The human Klotho VS variant: focus on the processing and function of the V, S and VS isoforms
… heterodimerization with FGFR1c. Addition of FGF23, for which KL is a co-receptor, showed that KLVS increases FGF signaling downstream of FGFR1c. To determine differences in enzymatic activity of KLVS, 4-metylumbelliferyl-beta-D-glucuronide was used to measure alterations in glucuronidase …
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Characterization of cochlear transcription, translation and energy extraction in aging and noise-induced pathology
… provide critical insight into the specific role Fgf23 plays in development and maintenance of the auditory system. The second arm of this thesis seeks to provide clinical practicality to the above work by developing a method to safely access the inner ear environment to gather and communicate …
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Role of the Vitamin D Receptor in Insulin Secretion and Beta Cell Function
… pathways via klotho’s role as a co-receptor for FGF23. By analysis of islets from Klotho-/- mice, we also show that the sialidase activity of klotho may modulate the membrane localization of GLUT-2 to affect glucose-stimulated insulin secretion. In summary, my studies suggest that vitamin D …
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Imaging Post-Infarct Myocardial Inflammation with ⁶⁸Ga-DOTATATE PET/MRI and insights into COVID-19 associated myocardial injury
… CCL3, CCL4, CCL7 (MCP-3), CXCL1, FGF21, FGF23, IL-13, PD-L1 and ST1A1 levels, as well as CD4+ Th2-like cells; but decreased CD8+ T effector memory cells, including PD1+ CD8+ T cells and CD8+ αβ T cells. Using Lasso regression analysis including all baseline clinical characteristics, …