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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 38 for “"FGF2"”.

  1. Unconventional Secretory Pathways : Protein Folding and Quality Control During FGF2 Membrane Translocation

    Backhaus, RafaelUniversität Heidelberg

    Fibroblast Growth Factor 2 (FGF2) ist ein proangiogener Wachstumsfaktor, der eine entscheidende Rolle bei der Tumor-induzierten Angiogenese spielt. FGF2 wird über einen bisher nicht bekannten Mechanismus von Säugetierzellen sezerniert, der auch nach Blockierung des ER/Golgi Systems durch Brefeldin …

    heid-diss Repository record

  2. Modulation of bovine preimplantation embryonic development and pregnancy by FGF2, LIF, and IGF1

    McDonald, KatyUniversity of Missouri--Columbia2023

    … the in vitro system. Fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), and insulin-like growth factor 1 (IGF1) as a cytokine cocktail named FLI, was first recognized for its role in embryonic stem cell derivation and then for improvements to in vitro porcine embryo production. …

    missouri Repository record

  3. The role of fibroblast growth factor-2 (FGF2) in vascular remodeling and adaptation

    Sullivan, Christopher JamesThe University of Arizona.2002

    … the hypothesis that fibroblast growth factor-2 (FGF2) is required during diseased-related vascular growth and remodeling in the adult organism. Given previous research, it is generally assumed that FGF2 is an important regulator of vessel growth during various pathophysiological processes (e.g. …

    arizona-thes Repository record

  4. Differential Impact of VEGF and FGF2 Signaling Mechanisms on Flt1 Pre-mRNA Splicing

    Payne, Laura BethVirginia Tech2016

    … the impact of endothelial mitogens VEGF and FGF2 (fibroblast growth factor 2), both of which are upregulated in preeclampsia, on Flt1 transcript variants in umbilical vein endothelial cells. We tested the hypothesis that VEGF modulates the expression of Flt1 variants via the signaling kinase …

    vt Repository record

  5. Mutational Analysis of the Export Targeting Motif of Fibroblast Growth Factor 2, a Mediator of Tumor-Induced Angiogenesis

    Engling, AndreUniversität Heidelberg

    … However, basic fibroblast growth factor (FGF2), a potent mediator of tumor-induced angiogenesis, has been shown to be secreted by a non-classical pathway that does not depend on the functions of the ER and the Golgi apparatus. The molecular characterization of the FGF2 export mechanism is …

    heid-diss Repository record

  6. Glycosaminoglycan-protein interactions : the fibroblast growth factor paradigm

    Kwan, Chi-Pong, 1973-Massachusetts Institute of Technology2002

    … proteins such as basic fibroblast growth factor (FGF2). A number of models have been proposed to account for the mode of FGF-FGFR interactions and the role of HSGAGs in modulating FGF2 signaling. It was hypothesized that one role played by HSGAGs was to stabilize FGF2 oligomers in a "side-by-side" …

    mit Repository record

  7. FGF signaling in specification of hESC-derived definitive endoderm

    Ameri, JacquelineStem Cells and Pancreas Development Biology2010

    … growth factor (FGF) signaling, specifically FGF2 and FGF4, and Retinoic acid (RA) in specification of the hESC-derived DE development. Studies in lower vertebrates have demonstrated that FGF2 acts in a restricted manner primarily patterning the ventral foregut endoderm into liver and lung, …

    lund Repository record

  8. Additive effects among uterine paracrine factors in promoting bovine trophoblast cell proliferation

    Xie, MingVirginia Tech2014

    … growth factor (EGF), fibroblast growth factor-2 (FGF2) and insulin-like growth factor-1 (IGF1) promote bovine trophoblast cell proliferation, and to decipher the intracellular signaling mechanisms employed by these growth factors to regulate cell proliferation. Pilot studies established effective …

    vt Repository record

  9. The role of heparin and heparin-binding growth factors in pre-eclampsia

    Nazir Ahmad Mohamad, F.Middlesex University2016

    … factor (PLGF), fibroblast growth factor 2 (FGF2), hepatocyte growth factor (HGF), platelet-derived growth factor (PDGF), heparin-binding epidermal growth factor (HB-EGF), midkine (MK), pleiotrophin (PTN), and cluster differentiation (CD105). The localisation of HBGFs and receptors VEGFR-1, …

    middlesex Repository record

  10. Investigating fibroblast growth factor and its role in canine osteosarcoma

    Camero, Corrine MichelleUniversity of Illinois at Urbana-Champaign2018

    … development, wound healing, and angiogenesis. FGF2, also termed basic FGF (bFGF), plays an important role in osteoblast proliferation and maintaining osteoblasts in an undifferentiated state. We hypothesize that 1) canine OS cells will express FGFRs and FGF2, 2) FGF signaling blockade will …

    uiuc Repository record

  11. Glycosaminoglycan regulation of cell function

    Berry, David (David A.)Massachusetts Institute of Technology2005

    … Understanding the role of HSGAGs in inducing FGF2 dimerization led to the development of a novel engineered protein that was found to be effective at promoting functional recovery in stroke. Subsequently, methods to isolate HSGAGs from the cell surface were optimized and the ability of HSGAGs …

    mit Repository record

  12. The Role of FGF Signaling in the Regulation of Adult Murine Cardiomyocyte Contractility and Pathologic Hypertrophy

    Cilvik, Sarah Nicole2014

    … heart, and published studies demonstrate that FGF2 is cardioprotective following cardiac stress or injury. Despite the importance of FGF2 following injury, mice that lack or overexpress FGF2 develop normally and do not have any cardiac phenotype under homeostatic conditions. It is currently …

    wustl Repository record

  13. Development of a reversible quiescence model to identify signals enabling glioblastoma cancer stem cell transition between active and quiescent states

    Robbins, Sarah2026

    … in combination with Fibroblast Growth Factor 2 (FGF2) for different durations (3, 4), to model different depths of quiescence. BMP4 plus FGF2 treatment results in cell cycle exit, downregulation of protein synthesis, a key hallmark of quiescence (5) and impaired tumourigenic potential. Intensity …

    plymouth Repository record

  14. Development and assessment of supercharged platelets as a novel drug delivery mechanism for promoting cardiac regeneration

    Mason, SamanthaUniversity of Cambridge2024

    … thymosin β4 (TB4), fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor A (VEGFA). These supercharged platelets aim to serve as a novel regenerative treatment for ischaemic heart disease, driving tissue repair and functional recovery in the injured heart by promoting …

    cambridge Repository record

  15. Conversion of equine umbilical cord matrix mesenchymal stem cells to the trophectoderm lineage using the Yamanaka reprogramming factors

    Reinholt, Brad M.Virginia Tech2015

    … cells supplemented with LIF (10 ng/mL) and FGF2 (4 ng/mL). Transduction generated 21 initial colonies. Of these, four survived beyond 20 passages. The transduced equine cells morphologically resembled ES cells and expressed cell surface antigens indicative of ES cells. Molecular evaluation …

    vt Repository record

  16. Investigating the role of ZEB2 in the establishment of neuroepithelial architecture and axon tract formation

    Giandomenico, Stefano LucaUniversity of Cambridge2020

    … We demonstrate that the secreted growth factor FGF2 is a positive regulator of ZEB2, which in turn suppresses FGF2 expression, thus establishing a link between ZEB2 and a known regulator of NEC proliferation. Preliminary gain-of-function (GOF) experiments confirm ZEB2 as a neurogenic driver and …

    cambridge Repository record

  17. Studies on the Roles of PDGFRA and EGFR in the Classification and Identification of Therapeutic Targets for Human Gliomas

    Chen, DongfengLund University2013

    … and maintained by fibroblast growth factor 2 (FGF2) in primary glioma cells. FGF2-dependent maintenance of PDGFRA expression was concordant with the maintenance of a subset of gliogenic genes and higher rates of cell proliferation. Our findings suggest a role of FGF2 in regulating PDGFRA …

    lund Repository record

  18. Estudio de la influencia de los fibroblastos del estroma tumoral en el comportamiento de los carcinomas mamarios

    González Llorente, Lucía2014

    … S100A4, factores de crecimiento (TGFß, HGF, FGF2, FGF7, PDGFA, PDGFB, VEGFA y IGF2), citoquinas inflamatorias (IL6 y IL8), quimiocinas (CCL2 y CXCL12), proteasas (uPA, MMP2, MMP9 y MMP11), el factor de transcripción NF¿B y TIMP1. También se analizó mediante cocultivos de los CAFs con dos …

    oviedo Repository record

  19. Identification, regulation and lineage tracing of embryonic olfactory progenitors

    Murdoch, BarbaraUniversity of British Columbia2008

    … of nestin+ progenitors in response to FGF2. I thus provide evidence for a novel neurogenic precursor, the RGLP of the OE, that can be regulated by FGF2, and provide the first evidence for intrinsic differences in the origin and spatiotemporal potential of distinct progenitors during OE …

    ubc Repository record

  20. From bench to bedside : elucidating vestibular schwannoma pathobiology to devise effective pharmacotherapies

    Dilwali, SonamMassachusetts Institute of Technology2014

    … otoprotective fibroblast growth factor 2 (FGF2) levels in VS secretions inversely correlate with degree of SNHL, suggesting that different ototoxic and otoprotective VS-secreted molecules modulate VS's effect on hearing. TNF[alpha] and FGF2 could serve as biomarkers or pharmacologic targets …

    mit Repository record

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