Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"FGF19"”.
-
Developmental signaling pathways in adult energy homeostasis
… by a member of the endocrine FGF family, FGF19. The three endocrine FGFs, FGF19 (FGF15 in mice), FGF21, and FGF23 have well described roles in the regulation of metabolic processes in adults. While FGF23 is primarily involved in the regulation of phosphate and vitamin D homeostasis, FGF19 …
-
Metabolic regulation by nuclear receptor FXR and micro RNA-34a in health and disease
… and genes in the fibroblast growth factor-19 (FGF19) signaling pathway. MicroRNAs (miRs) are a class of small noncoding RNAs, usually 20-22 nucleotides long, first processed in the nucleus by the enzyme Drosha and then processed to its mature form in the cytoplasm by Dicer. MiRs usually …
-
The development of a mouse model of post-bariatric hyperinsulinemic hypoglycemia
… a GTT or an insulin tolerance test. RESULTS: FGF19 was the most significantly upregulated protein in the PBH group at all time points. At 120 minutes postprandially, FGF19 was 2.1-fold higher in the PBH group (p < 1x10-5). Adenine was >2-fold higher at all time points (p < 1x10-8). Treatment …
-
Role of Src phosphorylation of FXR in bile acid regulation
… intestinal hormone fibroblast growth factor 19 (FGF19) and orphan nuclear receptor small heterodimer partner (SHP). In response to elevated hepatic bile acid levels FXR, acting directly as well as through FGF19 and SHP, inhibits the synthesis of bile acids, downregulates bile acid importers, …
-
Understanding the Molecular Basis for FGF15/19 and FGF21 Actions on Energy Homeostasis
… lead to physiological responses. One member, FGF19, causes reduced glucose and insulin levels with enhanced insulin sensitivity when expressed in transgenic mice. Another member, FGF21, has been shown to act as an insulin sensitizer pharmacologically by improving glucose tolerance and reducing …
-
THE ROLE OF BETA-KLOTHO PROTEIN IN NAFLD PATHOGENESIS
… mediates in the liver the hormonal activity of FGF19 and plays a central role in the regulation of lipid metabolism and in bile acids’ biosynthesis. Thus, a stable KLB full knock-out model in HepG2 hepatoma cells (KLB-/-) has been generated by using Crispr/Cas9 technology, with the aim to …