Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"FGF14"”.
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DISRUPTION OF THE HIPPOCAMPAL GABAERGIC SYSTEM IN THE Fgf14 ̶ / ̶ MOUSE MODEL
… the intracellular fibroblast growth factor 14 (FGF14), a molecule required for proper neuronal development, excitability, synaptic plasticity and cognitive function, leads to a reduction in PVIs in the hippocampal CA1 area, accompanied by declined expression of GABAergic presynaptic components, …
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CELLULAR ALTERATIONS OF ADULT HIPPOCAMPAL NEUROGENESIS IN THE FGF14−/− MOUSE MODEL
… role of the fibroblast growth factor 14 (FGF14), a disease-associated factor that controls neuronal excitability and synaptic plasticity in adult neurogenesis. It became clear that the genetic deletion of Fgf14 leads to previously undefined alterations in adult neurogenesis in the dentate …
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Regulation of the FGF14:Nav Interactome by a GSK-3 Centered Pathway
… have shown that the assembly and trafficking of FGF14, an intracellular fibroblast growth factor critical for the maintenance of the Nav complex, in neurons is controlled via a GSK-3 dependent signaling pathway (Shavkunov et al., 2013). Additionally, inhibition of GSK-3 reduces the assembly of …
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The Diversity of FHF-mediated Ion Channel Regulation
… the fibroblast growth factor family (FGFs, FGF11-FGF14) that bind directly to voltage gated sodium channels (VGSCs), thereby regulating channel activity and consequently neuronal excitability. Mutations in FGF14 cause spinocerebellar ataxia while FGF13 is a candidate for X-linked mental …
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Targeting protein: protein interaction sites for drug development against voltage-gated sodium channels
… the intracellular fibroblast growth factor 14 (FGF14). FGF14 is a biologically relevant accessory protein of the neuronal Nav channel complex controlling gating, stability, and trafficking of native Nav channels. Through a monomeric interaction with the intracellular C-terminal tail of Nav …
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Regulation of signaling and function of the voltage-gated sodium channel complex by protein:protein interactions
… regulatory protein, fibroblast growth factor 14 (FGF14). Using a newly developed assay we screen cellular pathways followed by biophysical validation, we discovered a mechanism by which the JAK2 tyrosine kinase might directly influence neuronal firing through phosphorylation of FGF14. Furthermore, …