Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"FGF signaling"”.
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FGF signaling in Xenopus laevis lens regeneration
… dissertation examines the relationship between FGF signaling and lens regeneration, exploring the hypothesis that the FGF signaling plays a key role in triggering lens regeneration. First, the mRNA expression levels of FGFs and FGFRs in the cornea and retina were observed, as the key ligand from …
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The Role of FGF Signaling in Retinal Development
… regions of the CNS. In the developing retina, FGFs are a large family of secreted polypeptide growth factors. Fgf15 is the major Fgf expressed during retinal development in mice. Fgf15 is an example of an FGF that has been shown to control proliferation, cell fate specification, differentiation …
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FGF signaling in specification of hESC-derived definitive endoderm
… the role of fibroblast growth factor (FGF) signaling, specifically FGF2 and FGF4, and Retinoic acid (RA) in specification of the hESC-derived DE development. Studies in lower vertebrates have demonstrated that FGF2 acts in a restricted manner primarily patterning the ventral foregut …
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Reiterative FGF signaling determines the identity and morphology of the lacrimal gland
… secretes the chemo-attractive signal of Fgf10, which binds to epithelial Fgfr2b and co-receptor heparan sulphate proteoglycans, to promote budding and branching morphogenesis of the lacrimal gland. However, the mechanism by which Fgf10 expression is regulated within the neural crest and …
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The Role of FGF Signaling in the Regulation of Adult Murine Cardiomyocyte Contractility and Pathologic Hypertrophy
… but ultimately becomes maladaptive. The signaling pathways that drive cardiac remodeling are extremely complex and poorly understood, and therefore, a better understanding of the mechanisms involved in the development and progression of CVDs is essential in order to diagnose and treat …
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Gcn5 Impacts Fgf Signaling At Multiple Levels and Activates C-Myc Target Genes During Early Differentiation of Embryoid Bodies
… is orchestrated by transcription factors, signaling pathways and co-regulators, with complex cross-regulatory events often occurring. Growing evidence has identified chromatin modifiers as important regulators for development as well, yet how particular chromatin modifying enzymes affect …
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The role of adaptor proteins Crk and CrkL in lens development
Cell shape changes and signaling pathways are essential for the development and function of the lens. During lens development proliferating epithelial cells will migrate down to the equator of the lens, differentiate into lens fiber cells, and begin to elongate along the lens capsule. The …
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Zebrafish Posterior Lateral Line Organogenesis Regulation by Notch Signaling
… Results in this thesis demonstrate that Notch signaling is an integral part of the feedback loop between Wnt and Fgf signaling that underlies the self‐organization of rosette‐shaped sensory organs in the zebrafish lateral line system. Notch cell autonomously induces apical constriction and cell …
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Patterning of the embryonic vertebrate Brain in Response to Fibroblast Growth Factor Signaling
… of the zebrafish, Fibroblast growth factors (Fgfs) are involved in the molecular patterning of various tissues, including two regions of the brain, the forebrain and the midbrain-hindbrain region, affecting cellular processes as diverse as cell proliferation, differentiation, and axonal …
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Investigating fibroblast growth factor and its role in canine osteosarcoma
… tumor microenvironment contains many cells and signaling molecules such as cytokines, chemokines and growth factors. Investigating these factors may identify a stimulus for a less differentiated and more aggressive neoplasia. This is even more compelling if the stimulus is a druggable target. …
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Signaling mechanisms and developmental function of fibroblast growth factor receptors in zebrafish
Fibroblast growth factor (Fgf) signaling plays multiple inductive roles during development of vertebrates (Itoh 2007). Some Fgfs, such as Fgf8, are locally secreted and signal over a long range to provide positional information in the target tissue (Scholpp and Brand 2004). Fgf ligands signal in a …
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The role of Wnt signalling during embryonic salivary gland development
… distally. We looked at the function of Wnt signaling during embryonic development of the submandibular and sublingual salivary glands and found that FGF signaling acts upstream of Wnt signaling and that Wnt and FGF signals coordinate branching morphogenesis and lumen formation. To locate the …
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Function and Regulation of the Conserved Wnt Target sp5 in the Vertebrate Nervous System
Wnt/β-catenin signaling culminates in the transcriptional regulation of target genes. Target genes mediate Wnt function during different developmental processes. A dysfunctional Wnt/β-catenin signaling results in aberrant regulation of the target genes that often causes developmental malformations …
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Gene expression studies of pregastrulation development: the basement membrane is essential for cell differentiation
… body (EB) cultures. Fibroblast growth factor (FGF) signaling is crucial when the step-like process of EB development is initiated with the formation of an endoderm. A subendodermal BM is formed, in which the globular domains LG4-5 of the laminin α1 chain (α1LG4-5) are responsible for the …
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A genetic analysis of somitogenesis in the Medaka (Oryzias latipes)
… interplay of different pathways. Notch/Delta signaling is one of the pathways well characterized in zebrafish through mutants affected in its different components. Previous work in mouse, chicken and zebrafish has shown that also additional components are required during somitogenesis, most …
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Regulation of FGF Receptor signalling by SPROUTY and SPRED
… from Fibroblast Growth Factor Receptors (FGFRs) is under tight control by a wide variety of extrinsic and intrinsic regulatory mechanisms, many of which remain poorly defined. Sproutys and their related Spred proteins constitute two such families of signalling regulators with multiple …
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Glycosaminoglycan regulation of cell function
… sulfate-GAG (HSGAG)-fibroblast growth factor (FGF) system was examined. Understanding the role of HSGAGs in inducing FGF2 dimerization led to the development of a novel engineered protein that was found to be effective at promoting functional recovery in stroke. Subsequently, methods to isolate …
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A novel low-density lipoprotein receptor-related protein protects against environmental teratogens
… interaction with the fibroblast growth factor (FGF) signaling pathway in the post migratory cranial neural crest. Collectively, these data characterize a novel genetic locus and provide insight into the complex multifactorial etiology of congenital malformations.
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Glycomics : an emerging paradigm to protein-carbohydrate interactions
… GAGs (HSGAGs) - fibroblast growth factor (FGF) as a model GAG-protein system, the first part focuses on determining the structural basis of FGF oligomerization, sequence specific FGF-HSGAG interactions and FGF-receptor (FGFR) interactions which collectively influence the specificity of …
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Multiple Conserved Enhancers of the Osteoblast Master Transcription Factor, Runx2, Integrate Diverse Signaling Pathways to Direct Expression to Developing Bone
… of RUNX2 itself is positively regulated by the FGF signaling pathway, an enhancer in the last intron of the adjacent gene, SUPT3H, is regulated by canonical Wnt signaling, and a distant downstream enhancer requires a conserved Dlx binding site for its activity. While all of these pathways and …
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