Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"FGF receptor"”.
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Regulation of FGF Receptor signalling by SPROUTY and SPRED
Signalling from Fibroblast Growth Factor Receptors (FGFRs) is under tight control by a wide variety of extrinsic and intrinsic regulatory mechanisms, many of which remain poorly defined. Sproutys and their related Spred proteins constitute two such families of signalling regulators with multiple …
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The Role of Tyrosine Kinase Growth Factor Receptors in Psoriatic Epidermal Hyperplasia: Analysis of Growth Factor Synergy in Cultured Human Keratinocytes and Receptor Expression in Psoriatic Skin
… the disease. The epidermal growth factor (EGF) receptor pathway is an important mediator of keratinocyte growth and both ligand and receptorcomponents of this pathway are abnormally expressed in hyperproliferative epidermis. In contrast, little is known about the function of other growth factor …
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Function of two closely related fibroblast growth factors in early mesoderm development of <em>Drosophila melanogaster</em>
… the ligands for the Fibroblast-Growth-Factor (FGF)receptor Heartless (Htl), which is expressed in all mesodermal cells during gastrulation. To understand how these two FGFs orchestrate mesoderm spreading in gastrulation and mesoderm differentiation during organogenesis, loss and gain of …
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The instructive roles of muscle cells in planarian regeneration
… The resulting axial gene expression map included FGF receptor-like (FGFRL) homologs and genes encoding components of Wnt signaling. Two distinct FGFRL-Wnt circuits, involving juxtaposed anterior FGFRL and posterior Wnt expression domains, controlled head and trunk patterning.
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Temporal and spatial controls of cell fate specification in the cerebellum
… I also demonstrate the role of the isthmic gene, Fgf8, in the maintenance of the expanded domain through in ovo electroporation of plasmids encoding Fgf8 and a dominant-negative FGF receptor. This FGF-dependent domain of Atoh1 is regulated independently from the specification of rhombic lip …
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The Role of FGF Signaling in Retinal Development
… regions of the CNS. In the developing retina, FGFs are a large family of secreted polypeptide growth factors. Fgf15 is the major Fgf expressed during retinal development in mice. Fgf15 is an example of an FGF that has been shown to control proliferation, cell fate specification, differentiation …
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Glycomics : an emerging paradigm to protein-carbohydrate interactions
… GAGs (HSGAGs) - fibroblast growth factor (FGF) as a model GAG-protein system, the first part focuses on determining the structural basis of FGF oligomerization, sequence specific FGF-HSGAG interactions and FGF-receptor (FGFR) interactions which collectively influence the specificity of …
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Age differentiation of rat smooth muscle cells : altered proliferation profile, cellular changes, and implications for atherosclerotic plaque destabilization
… profile and stimulation/inhibition response, FGF receptor production and expression, and MAPK production and activation. We found that the overall cellular production of receptor and MAPK in smooth muscle cells remains unaffected by aging. However, the proliferation response of aged smooth …
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Mechanisms of Induction and Maintenance of Constitutive Ptgs2 Expression in Colonic Mesenchymal Stem Cells
… of Ptgs2 expression. We determined that Fgf9 can regulate Ptgs2 through Fgf receptor expressed preferentially in cMSCs. Downstream of Fgf9, phosphorylation of Erk and increased abundance of mRNA binding protein CUGbp2 augments Ptgs2 expression. Furthermore, Fgf9 expression in the adult …
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Patterning of the embryonic vertebrate Brain in Response to Fibroblast Growth Factor Signaling
… of the zebrafish, Fibroblast growth factors (Fgfs) are involved in the molecular patterning of various tissues, including two regions of the brain, the forebrain and the midbrain-hindbrain region, affecting cellular processes as diverse as cell proliferation, differentiation, and axonal …
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The Role of FGF Signaling in the Regulation of Adult Murine Cardiomyocyte Contractility and Pathologic Hypertrophy
… more effectively. Fibroblast growth factors (FGFs) and their receptors are part of a large family of highly conserved signaling molecules that have been implicated in postnatal cardiac remodeling. FGF signaling increases following injury to the heart, and published studies demonstrate that …
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The Liver-Derived Endocrine Hormone FGF21 Alters Metabolism and Diurnal Behavior via the Nervous System
… endocrine hormone fibroblast growth factor 21 (FGF21) is induced in chronic fasting and acts as a global starvation signal. Previous studies focusing on FGF21 as an anti-diabetic drug indicate that FGF21 coordinates whole-body fat utilization and energy expenditure. However, its basic …
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Molecular and cellular regulation of motoneuron differentiation of human neural stem cells
… consisting of basic fibroblast growth factor (bFGF), heparin and laminin (FHL), which directs human fetal neural stem cells (hNSCs) to differentiate into choline acetyltransferase (ChAT) motoneurons in vitro and after transplantation into the rodent spinal cord in vivo. However, the mechanisms …
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Gene expression studies of pregastrulation development: the basement membrane is essential for cell differentiation
… body (EB) cultures. Fibroblast growth factor (FGF) signaling is crucial when the step-like process of EB development is initiated with the formation of an endoderm. A subendodermal BM is formed, in which the globular domains LG4-5 of the laminin α1 chain (α1LG4-5) are responsible for the …
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A novel role for Sprouty2 in co-ordinating airway and vascular growth of the fetal lung.
… tube elongation, Fibroblast Growth Factor 10 (FGF10) and the pro-vasculogenic transcription factor, Hypoxia Inducible Factor 1a (HIF-1a). The FGF receptor antagonist, Sprouty2 (SPRY2), influences the duration of this signalling activity and thus governs periodical airway and vascular branching. …
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Identification and characterization of genetic interactors of the Rho Guanine-nucleotide exchange factor Pebble in <em>Drosophila</em>
… spreading of mesoderm cells is controlled by the FGF signalling pathway acting through the FGF receptor Heartless (Htl). Pbl represents an important downstream component of this FGF pathway and activates the Rho GTPase Rac, but the regulation of Pbl by FGF signalling is unclear. Furthermore Pbl is …
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Determining the Signalling Pathways that Govern Human Naive Pluripotency
… human embryonic stem cells (hESCs) rely on FGF and TGFβ signalling for self-renewal, and occupy a developmentally advanced state of pluripotency comparable to mouse EpiSCs. Recent reports demonstrate that a naïve state of human pluripotency can be consistently derived either through …
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Collective Chemotaxis of Retinal Neural Cells from Drosophila Melanogaster in Controlled Microenvironments
… for Drosophila. A fibroblast growth factor-8 (FGF-8) gradient (100ng/mL) was applied and images of the cell migration were taken every 30 seconds for 4 hours. Theresults showed that clusters experienced a gradient dependent system, indicating that as the gradient increased, net displacement …
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FGF signaling in specification of hESC-derived definitive endoderm
… the role of fibroblast growth factor (FGF) signaling, specifically FGF2 and FGF4, and Retinoic acid (RA) in specification of the hESC-derived DE development. Studies in lower vertebrates have demonstrated that FGF2 acts in a restricted manner primarily patterning the ventral foregut …
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Signalling and transcriptional regulation of human primordial germ cell specification
… by hPGCLC induction. I found that inhibition of FGF receptor (FGFR) or its downstream effectors (MEK and PI3K) enhanced competency for PGC fate. By contrast, premature MEK/ERK activation in hESCs resulted in aberrant expression of endoderm markers and loss of germ cell potential. Altogether the …
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