Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 183 for “"FGF"”.
-
FGF signaling in Xenopus laevis lens regeneration
… dissertation examines the relationship between FGF signaling and lens regeneration, exploring the hypothesis that the FGF signaling plays a key role in triggering lens regeneration. First, the mRNA expression levels of FGFs and FGFRs in the cornea and retina were observed, as the key ligand from …
-
The Role of FGF Signaling in Retinal Development
… regions of the CNS. In the developing retina, FGFs are a large family of secreted polypeptide growth factors. Fgf15 is the major Fgf expressed during retinal development in mice. Fgf15 is an example of an FGF that has been shown to control proliferation, cell fate specification, differentiation …
-
FGF signaling in specification of hESC-derived definitive endoderm
… the role of fibroblast growth factor (FGF) signaling, specifically FGF2 and FGF4, and Retinoic acid (RA) in specification of the hESC-derived DE development. Studies in lower vertebrates have demonstrated that FGF2 acts in a restricted manner primarily patterning the ventral foregut …
-
Regulation of FGF Receptor signalling by SPROUTY and SPRED
… from Fibroblast Growth Factor Receptors (FGFRs) is under tight control by a wide variety of extrinsic and intrinsic regulatory mechanisms, many of which remain poorly defined. Sproutys and their related Spred proteins constitute two such families of signalling regulators with multiple …
-
Reiterative FGF signaling determines the identity and morphology of the lacrimal gland
… secretes the chemo-attractive signal of Fgf10, which binds to epithelial Fgfr2b and co-receptor heparan sulphate proteoglycans, to promote budding and branching morphogenesis of the lacrimal gland. However, the mechanism by which Fgf10 expression is regulated within the neural crest and …
-
ANAGRELIDE E FATTORE DI CRESCITA FIBROBLASTICO-2 (FGF-2) NELLA TROMBOCITEMIA ESSENZIALE
anagrelide and fibroblast growth factor-2 levels in essential thrombocythemia, anagrelide and fibroblast growth factor-2 levels in patientswith essential thrombocythemia, abnormal production of interleukin (IL)-6 in essential thrombocythemia, janus kinase V617F mutation and inflammatory …
-
Größenegulation der Augenanlage von Xenopus laevis durch Inhibition von Hedgehog-, Fgf- und Wnt-Signalen
… gleichzeitige Inhibition dreier Signalwege (Shh, Fgf und Wnt) zu einer enormen Vergrößerung des Auges führt. Diese multiple Inhibition wird durch Überexpression des Hedgehog-interagierenden Proteins (Hip) erreicht, eines ursprünglich als Hedgehog-spezifisch charakterisierten Antagonisten, welcher …
-
Role of p53 and its isoforms in the expression of FGF-2 and tumoral neovascularization
… and tumor progression. I also focused my work on FGF-2 regulation by p53. In a first part, full length p53 (p53) and/or D133p53 isoforms were selectively knocked-down with siRNAs in human glioblastoma cells U87. Conditioned medium produced by tumour cells knocked- down for D133p53 inhibited …
-
The Role of FGF Signaling in the Regulation of Adult Murine Cardiomyocyte Contractility and Pathologic Hypertrophy
… more effectively. Fibroblast growth factors (FGFs) and their receptors are part of a large family of highly conserved signaling molecules that have been implicated in postnatal cardiac remodeling. FGF signaling increases following injury to the heart, and published studies demonstrate that …
-
The roles of FGF and Wnt signaling during maxillary barbel regeneration in the Zebrafish (Danio rerio).
… this regeneration. Fibroblast growth factor (FGF) and wingless (Wnt) signaling are required for the control of zebrafish caudal fin regeneration; due to the similarities between the fin and the maxillary barbel, these regulatory networks may play a role in barbel regeneration as well. In this …
-
Limb cell behaviors in Monodelphis domestica growth and development: the effects of Fgf pathway activators and inhibitors
… (Chapter 1). I then elucidated the role of the Fgf/MAPK signaling pathway in driving these cellular processes (Chapter 2). Results suggest that molecular signals from within the limb drive differences in cell proliferation and focal adhesion that contribute to the differential growth of the …
-
Therapeutische Angiogenese bei chronischer Myokardischämie - Applikation von FGF-2 mittels selektiver druckregulierter Retroinfusion im tierexperimentellen Modell am Schwein
… Retroinfusion des vaskulären Wachstumsfaktors FGF-2 in die Koronarvene auf das Kollateralwachstum (Arteriogenese), das Kapillarwachstum (Angiogenese), den myokardialen Blutfluss und die kontraktile Myokardfunktion bei chronischer, experimenteller Myokardischämie (Schwein) untersucht, und mit …
-
Gcn5 Impacts Fgf Signaling At Multiple Levels and Activates C-Myc Target Genes During Early Differentiation of Embryoid Bodies
… of multiple genes encoding components of the FGF signaling pathway, and for normal activation of ERK and p38 downstream of FGF signaling at early stages of EB formation. Loss of <em>Gcn5</em> is associated with disorganized cytoskeletal networks, and compromised capacity of ESCs to …
-
The Role of Secondary and Tertiary Structure in the Cap-Independent Translation of FGF-9 and HIF-1-alpha
… by primer extension (SHAPE), I found that the FGF-9 5’ UTR RNA, an oncogenic IRES-like translational enhancer, and the HIF-1-alpha 5’ UTR RNA, an oncogenic CITE-like translational enhancer, take on complex, distinct secondary structures. Protein toeprinting, DAP5 SHAPE footprinting, and UV …
-
The OP27 cell line as a model system to study the effects of FGF-2 in olfactory neuronal development
… test the effects of fibroblast growth factor-2 (FGF-2) in directing olfactory neurogenesis. The OP27 cells proliferate under the control of the retrovirus at the permissive temperature (33°C). When shifted to the non-permissive temperature (39°C) the SV40 large T antigen is inactivated and the …
-
Preparation of Heparin Surface for Quantification of Fibroblast Growth Factor-2 (FGF-2) Binding Using Surface Plasmon Resonance (SPR)
… the interactions of fibroblast growth factor-2 (FGF-2) with the surface bound heparin. Kinetic rate constants of association and disassociation were calculated. The association data of FGF-2 with heparin was fit to a single compartment, well-mixed model as the data did not exhibit mass transfer …
-
Endothelial cells and basement membrane : a co-regulatory unit for fibroblast growth factor-2 in hyperglycemic stress
… and function of fibroblast growth factor-2 (FGF-2) through changes in interaction between endothelial cells and basement membrane. We discovered that basement membrane associated FGF-2 increased linearly with culture glucose concentration. Using novel assays, we demonstrated that FGF-2 …
Page 1 of 10