Global ETD Search
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Showing 1 to 8 of 8 for “"FG Nups"”.
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Selective transport of the nuclear pore complex studied through all-atom and coarse-grained molecular dynamics simulations
… central pore are many intrinsically unstructured FG-nups, proteins that contain phenylalanine-glycine repeating sequences (FG-repeats) separated by hydrophilic linker regions. Because of the unstructured nature of FG-nups, no imaging method has been able to capture the collective conformation of …
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Structure and Organization of Nuclear Pore Proteins
… structural techniques. These proteins (the FG nups) contain multiple phenylanine-glycine repeats, which bind cargo and transport it through the pore. Although many conflicting models for transport have been proposed, the mechanism still remains unclear. Polarization fluorescence microscopy …
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Biochemical Analysis of the Protein-Protein Interactions Involved in Karyopherin-Mediated Transport Across the Nuclear Pore Complex
… or Kaps). Kap-mediated transport involves FG-nups, a family of NPC proteins. While much has been learned about the mechanism of nucleocytoplasmic transport, many details are still unknown; perhaps among the most important missing details is the binding kinetics of almost all the transport …
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Conformational Dynamics of the Nuclear Pore Complex Studied With Coarse-Grained Modelling and Polarized Light Microscopy
… role for the phenylalanine-glycine nucleoporins (FG-Nups). I constructed a coarse-grained model to investigate the dynamics of these proteins. My coarse-grained model was able to recapitulate in vivo experimental results previously measured in our lab. My results also suggest that, at the …
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Molecular Size and Charge Effects on Nucleocytoplasmic Transport Studied By Single-Molecule Microscopy
… by the natively unfolded phenylalanine-glycine (FG)-nucleoporins (Nups), in the NPC allows for two transport modes: passive diffusion of small signal-independent molecules (< 20-40 kDa) and transport-receptor facilitated translocation of signal-dependant cargoes. The molecular size of a cargo …
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Investigation of Nuclear Pore Complex Protein Interactions and the Implications for Nuclear Transport
… material across the nuclear pore complex and FG-nucleoporins, proteins which compose the complex itself and are of great importance in allowing protected nuclear transport. Molecular dynamics simulations have been performed on transport complexes formed by the transport receptors …
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Investigation of nuclear pore complex protein Interactions and the implications for nuclear transport
… material across the nuclear pore complex and FG-nucleoporins, proteins which compose the complex itself and are of great importance in allowing protected nuclear transport. Molecular dynamics simulations have been performed on transport complexes formed by the transport receptors importin-B, …
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Molecular mechanisms of gating and selectivity in transport channels
… that are rich in phenylaline- glycine motifs (FG-nups) form the central transport channel. Small molecules passively diffuse through the channel but, larger molecules are selectively transported via transport factors (TFs), which apparently interact with the FG-repeats of the nups in the …