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Showing 1 to 14 of 14 for “"FERM"”.
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Regulation of Cell Adhesion By The Ferm Proteins, Ptpn14 and Merlin
… that regulate cell-cell adhesions is the FERM (<strong>4</strong>.1 protein, <strong>E</strong>zrin, <strong>R</strong>adixin, <strong>M</strong>oesin) domain-containing proteins.One FERM domain protein, the non-receptor tyrosine phosphatase PTPN14<em>,</em> is mutated or deleted in …
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MyTH4 and FERM Have Overlapping and Distinct Roles in the Function of Myo1, a Class XIV Myosin in Tetrahymena thermophila
<p>MyTH4 and FERM are conserved tail domains in myosin classes VII, X, XII, XIV, XV and in MyoG. Myo1, a class XIV myosin in Tetrahymena thermophila, contains MyTH4 and FERM. Previous studies have shown that Myo1 localizes to phagosomes, the cytoskeleton, and the macronucleus, and that phagosome …
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Dissecting the Function of FARP1 and Rho GTPases in Semaphorin-Plexin Signaling: Structural Perspective
… and neurite outgrowth. Also, the N-terminal FERM domain of FARPs is known to interact with the cytoplasmic domain of Plexin. To interrogate how FERM interacts with Plexin and how this interaction might regulate Plexin signaling, I characterized the interaction of FERM with Plexin both …
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Analysis of Band 4.1B In Integrin-Mediated Cell Adhesion and Signaling
… via its band 4.1, ezrin, radixin, and moesin (FERM) domain in cell adhesions. In astrocytes, both Band 4.1B and β1 integrin were expressed in cell-ECM contact sites during early cell spreading. Exogenous expression of Band 4.1B, especially its FERM domain, enhanced cell spreading on …
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Consciència de l'ús lingüístic : anàlisi dels factors que influeixen en les tries lingüístiques
… de tot tipus, però a dia d'avui, es manté ferm a bona part dels Països Catalans. La situació lingüística a Catalunya sembla viure una conjuntura curiosa: mentre que l'ensenyament de la llengua catalana és, avui per avui, garantit a tots els centres públics, l'ús que els ciutadans fan del …
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The Effects of the Storage Conditions of the Juice and the Effects of Nutrient Supplementation on Wine Fermentation
… conditions of Concord grape juice prior to fermentation and types of supplementation during fermentation were studied. Two batches of juice were stored, one at ambient temperature and one at 4.4°C, and were then fermented using four different nitrogen supplementation methods: a control with …
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Genetic and mechanistic determinants of prostate cancer progression and metastasis
… of Protein 4.1B, a 4.1/ezrin/radixin/moesin (FERM) domain-containing cytoskeletal protein, is a frequent event in prostate cancer. The significance of this finding was confirmed by experimental ablation of 4.1B, which enhanced tumor progression and metastasis, at least in part, by protecting …
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Metastatic Reactivation and Progression Result From Fak-Mediated Disruption of Innate Immune Signaling
… signaling pathway. Mechanistically, through its FERM domain, Fak disrupts phosphorylation, dimerization, and nuclear translocation of interferon regulatory factor 3 (Irf3) downstream of Sting activation. Single-cell RNA sequencing analysis from both patients and human xenograft models, spanning …
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Compartmentalization and axon guidance in the Drosophila brain
… contains a central PDZ domain and an N-terminus FERM domain. The in vivo role of this family of proteins is unknown. To explore the function of Ptpmeg in flies, mutants were generated by targeted gene disruption. Examination of the adult nervous system of Ptpmeg mutants reveals a defect in the …
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Molecular and Functional Analysis of two Gene Trap Mouse Lines
… zeigt. Eine Gemeinsamkeit dieser Familie ist die FERM-Domäne. Es konnte gezeigt werden, dass dieses Protein eine wichtige Rolle in der Regulierung von Zytoskelett-Plasmamembran-Interaktionen spielt. Gtl8 könnte eine ähnliche Funktion ausüben, da das Protein in der Nähe der Membran, besonders in …
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Towards a legal history of white women in the Transvaal, 1877-1899
… wanneer dit kom by geskiedenis in hofsake. ‘n Ferm blik moet natuurlik ook gehou word op konsepte soos ‘gender’ en ‘dekonstruksie’ aangesien dit bepaal hoe die bronne benader moet word. ‘n Geskiedenis van Transvaal is nodig, want dit moet moontlik wees om vroue te posisioneeer binne die …
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Insights into the Synthesis, Mechanism of Action, and Biosynthesis of a Novel Lipodepsipeptide Antibiotic, WAP-8294A2
… from the soil bacteria Lysobacter staphylocidin (FERM BP-4900) in Japan in 1997. It is the major component of a mixture of eighteen related compounds, all of which showed antibiotic activity.13 WAP-8294A2 showed strong in vitro antibiotic activity against Gram-positive bacteria including …
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NEUROFIBROMATOSIS TYPE 2 PROTEIN (NF2) AS A REGULATOR OF TUMOR SUPPRESSORS AND VIRAL ONCOPROTEINS IN HUMAN GLIOBLASTOMA
… between T-antigen and NF2 maps to the FERM domain of NF2 domain of NF2, which has been shown previously to be responsible for its tumor suppressor activity. Co-immunoprecipitation assays performed on a glioblastoma cell line revealed a ternary complex consisting of NF2, T-antigen, and …