Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"FEN1"”.
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Flap Endonuclease 1 ensures telomere replication and stability
… and repair protein, Flap Endonulcease 1: FEN1), in telomere replication and maintenance. I demonstrate that FEN1 is essential for the efficient replication of telomeres through its ability to re-initiate stalled replication forks. FEN1 depletion leads to telomere dysfunction characterized …
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The Functions of Human Dna2 in Mitochondrial and Nuclear DNA Maintenance
… percent of flaps that escape the activities of FEN1, hDna2 depletion did not result in slower maturation of newly synthesized DNA. In contrast, FEN1-depleted cells did result in slower maturation confirming that FEN1 is the main flap endonuclease that processes Okazaki fragments into ligable …
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Essentiality of Mitochondrial Genome Integrity in Cell Survival
… mitochondria have been proposed: EXOG, DNA2, and FEN1. EXOG is the only endo/exonuclease that exists exclusively in the mitochondria, and my results suggest that EXOG is the predominant 5’ end cleaning enzyme in mitochondrial LP-BER. Immunoprecipitation of EXOG-FLAG immunocomplex showed the …
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Clarifying the Role of the CST Complex in DNA Replication and Repair
… in the BER pathway including Pol β, APE1, FEN1, and LIGI. CST’s ability to augment these BER-associated proteins could be instrumental in promoting efficient DNA repair. Additionally, we find that CTC1 and STN1 are able to significantly enhance the polymerase activity of Pol δ and Pol α on …
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Positionsklonierung des Morbus Best-Gens VMD2
… werden. Mit FTH1 ('ferritin heavy chain 1') und FEN1 ('flap endonuclease 1') liegen zudem zwei bekannte Gene im analysierten Intervall, deren cDNA-Sequenzen bereits 1984 bzw. 1995 von anderen Forschungsgruppen isoliert und publiziert wurden. Zweifellos kann die Region als sehr genreicher …
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Replication-associated base excision repair Of oxidized bases in the mammalian genome
… Nuclear Antigen (PCNA), Flap Endonuclease 1 (FEN1), DNA Polymerase ä, Replication Factor C (RFC), and DNA Ligase I as well as the stress responsive Rad9-Rad1-Hus1 (9-1-1) DNA sliding clamp. We mapped the overlapping binding sites for all of these interacting protein partners to a small …
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Functional Roles of Nucleases in DNA Metabolism and Genome Stability
… suitable for repair by DNA polymerase δ, FEN1 and DNA ligase.</p>
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Making Molecular Movies: Using Single-Molecule Techniques to Unveil Hidden Features of Protein-Chromatin Interactions
… PCNA-binding partner and flap endonuclease, FEN1. Together our findings show how PCNA-enabled DNA synthesis is regulated by functions of its binding partners that are separate from their own catatlytic activities and assigns a role for the previously elusive RFC BRCT domain. This study is in …