Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"FDR control"”.
-
Assessment of Penalized Regression for Genome-wide Association Studies
… and SNP selection by False Discovery Rate (FDR) control, and assess their performance (including penalties incorporating linkage disequilibrium) in comparison with SMA. PR methods were compared with SMA on realistically simulated GWAS data consisting of genotype data from single and multiple …
-
New Results on the False Discovery Rate
The false discovery rate (FDR) introduced by Benjamini and Hochberg (1995) is perhaps the most standard error controlling measure being used in a wide variety of applications involving multiple hypothesis testing. There are two approaches to control the FDR - the fixed error rate approach of …
-
Outcome selection in longitudinal analysis of immunological data
… of families of tests for false discovery rate (FDR) corrections. When outcomes are selected via PCA-only dimension reduction, more tests are performed simultaneously and require correction. It was hypothesised that HCA followed by PCA would yield more significant discoveries after FDR control. …
-
Multiple Testing Embedded in an Aggregation Tree With Applications to Omics Data
… and under mild assumptions, asymptotically control the layer-specific and overall false discovery rate (FDR). Simulations verify our theoretical results. When applied to real flow cytometry data, TEAM captures cell subtypes that are overexpressed in cytomegalovirus stimulation vs. control. …
-
Mixture Model Approaches to Integrative Analysis of Multi-Omics Data and Spatially Correlated Genomic Data
… of a large <em>p</em> small <em>n</em> case-control epigenome-wide association study of pancreatic cancer (PanC). We demonstrated the effectiveness of our strategy through the detection and validation of methylation changes associated with PanC risk. We further discovered functional …
-
Multiple testing in spatial epidemiology: a Bayesian approach
… method, which focus on multiple testing control, without however leaving the preliminary study perspective that an analysis on SMR indicators is asked to. We implement the control of the FDR, a quantity largely used to address multiple comparisons problems in the eld of microarray data …
-
Enhancing Pavement Surface Macrotexture Characterization
… Texture Meter (CTMeter) that was chosen as the control device. Although this first method was able to successfully remove the spikes, it has the drawback that it depends on manual modeling of the distribution of the wavelet coefficients to correctly define an appropriate threshold. The next step …
-
Multiple testing procedures for complex structured hypotheses and directional decisions
… and aims at answering research questions while controlling appropriate error rates. In the first part of the thesis, a mixed directional false discovery rate (mdFDR) controlling procedure is developed in the context of uterine fibroid gene expression data (Davis et al., 2013). The main question …
-
Evaluation of the difference between two spatiotemporal random fields
Comparing the spatial characteristics of spatiotemporal random fields is often in demand in various fields of study. Especially in climatology, people are interested in learning the difference between the synthetic climate simulation model and climate field reconstructions (CFR) which are estimates …