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Showing 1 to 18 of 18 for “"FCCP"”.
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Protektive in vitro Wirkung mitochondrialer Entkoppler auf die Apoptose in Leukämiezellinien
… mitochondrialer Atmung und Phosphorylierung, FCCP, verursacht durch eine Erhöhung der Permeabilität der inneren mitochondrialen Membran für Protonen ähnliche Störungen der mitochondrialen Funktion. Ziel dieser Arbeit war es, den Effekt des mitochondrialen Entkopplers FCCP alleine oder in …
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Chemical probes for the study of mitochondrial oxidative stress
… uncoupling molecules (SUMs), DNP-SUM vii and FCCP-SUM viii, were designed to react with H2O2 and release a mitochondrial uncoupler. These were synthesised and their reaction with H2O2 was examined using UV spectrophotometry. DNP-SUM vii reacted slowly with a second order rate constant of 0.20 …
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Zytosolisches Calcium in murinen Hirnstamm-Motoneuronen wird differenziert von Mitochondrien reguliert
… bath application des mitochondrialen uncoupler FCCP (Carbonyl cyanide 4-trifluromethoxyphenylhydrazone) eine signifikante Verzögerung der zytosolischen Kalziumentfernung sowie eine substantielle Kalziumfreisetzung aus Mitochondrien. Diese Ergebnisse ähnelten den Beobachtungen von vulnerablen …
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Healthy hearts in family child care: what is the current state of provider health?
Family child care providers (FCCPs) are an important source of child care for close to 1.5 million children under the age of five (Laughlin, 2013). FCCPs provide care to children in their own homes and tend to be a source of care for lower income children. As child care has been identified as a …
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Investigating the role of the Nrf2-Keap1 pathway in mitophagy
… cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP), an uncoupler of oxidative phosphorylation. PINK1 did not influence Nrf2 transcript, protein levels, half-life, subcellular localisation or transcriptional activity. However, FCCP induced Nrf2 at the transcript and protein levels, and …
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Grafting polymers on nanosheets : a route for the fabrication of freestanding polymer brushes
… of fully cross-linked and chemically patterned (FCCP) monolayers has been developed in this work. FCCP monolayers can be further chemically functionalized. Chemically defined surface structures are of great practical interest, as they may be used in many technologies such as molecular …
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Applying Flinet Deep Learning Model to Fluorescence Lifetime Imaging Microscopy for Lifetime Parameter Prediction
… the offset. Samples with uncoupled mitochondria (FCCP) consistently show the highest structural similarity index measure (SSIM) values across all parameters, suggesting the model performs best under these conditions. Control samples demonstrate stable, intermediate SSIM values, while inhibited …
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Redoxmodulation Hippokampaler Neurone
… Depolarisation der Mitochondrien durch z.B. 1 µM FCCP oder 1 mM NaCN erhöhte die Hypoxieempfindlichkeit deutlich und konnte trotz Anwesenheit von O2 zur Auslösung einer spreading depression (SD) führen. Ein Anstieg der endogenen Superoxid- oder Hydroxylradikal-Produktion beschleunigte das …
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Caracterização da resposta imunometabólica frente a infecção por Leishmania amazonensis e Leishmania braziliensis em macrófagos de camundongos BALB/C
… Murine macrophages treated with antimycin A and FCCP, mitochondrial metabolism inhibitory drugs, showed a reduction in parasite burden and infection rate, highlighting the importance of mitochondrial metabolism for parasite survival. Although infection does not increase basal respiration in …
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Optical Analysis of Mitochondrial Function and Heterogeneity in Cultured Hippocampal Astrocytes
… die durch die Applikation von Zyanid, FCCP und anderen Chemikalien simuliert wurden. Regelmäßige m Schwankungen erschienen dabei zunehmend eine natürliche Charakteristik von Mitochondrien mit funktionierender Atmungskette und intrazellulärem Ca2+ Haushalt zu sein, wie durch …
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Anatomical, developmental and physiological aspects of silica in wheat
… erythrosin B) and ionophores (nigericin, FCCP). The data suggests that functional ATPases and a proton gradient are required for silica uptake. Transport into the xylem and uptake at the root surface may be differentially affected by the inhibitors.
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Pharmacological regulation and function of store-operated calcium channels
… acid, 4-chloro-3-ethylphenol, U73122 and FCCP. The aggregation of STIM1 in the cytosol could be a novel mechanism for the inhibition of SOCE, and the process did not rely on the depletion of ER Ca²⁺ store. The ryanodine receptor agonist 4-chloro-3-ethylphenol not only caused Ca²⁺ release …
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Mitochondrial Function as a Tool for Assessing Function, Quality and Adulteration in Medicinal Herbal Teas
… 2000 μg / mL OLTE (oligomycin: 29.94%, p < 0.01; FCCP: 43.2%, p < 0.01; antimycin A & rotenone: 32.09%, p < 0.01). Further investigation revealed improved survival in 2000 μg / mL OLTE pre-treated MCF10A cells given cisplatin (50 μM: 11.79%, p < 0.05; 100 μM: 8.186%, p < 0.001), but had no effect …
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Reactive oxygen and nitrogen species production in cardiomyoblasts during hypoxia and reoxygenation
… O2 for 4h hypoxia. The mitochondrial uncoupler; FCCP significantly reduced cell death via a O2-• dependent mechanism during 2% O2, 30min hypoxia. During hypoxia (2% O2, 4h)/ reperfusion (21% O2, 2h), metabolic activity was significantly reduced with increased production of O2-• and •NO, during …
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Molecular characterization of cation-coupled transporters: the H+-coupled Mg2+-citrate transporter, CitM, and the Na+/sulfate cotransporter, hNaSi-1
… the transmembrane proton gradient, including FCCP, TCC and nigericin, suggesting a proton-coupled transport. Valinomycin did not affect the uptake by CitM, supporting an electroneutral transport model in which one proton is coupled to the uptake of one complex of (Mg2+-citrate)1-. \r\n\r\nThe …
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Interactions with bioenergetics by the mitochondria-targeted anti-apoptotic imidazole fatty acid derivative ‘TPP-IOA’.
… of both ADP-phosphorylating-respiration and FCCP-uncoupled respiration, and stimulation of non-phosphorylating respiration. Critically, TPP-IOA was unable to inhibit pro-apoptotic peroxidase activity at concentrations that avoided interference to oxidative phosphorylation, suggesting it may …
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Family child care physical activity ecology: A qualitative GIS study
… per hour of care. Family child care providers (FCCPs) and settings play a fundamental role in shaping preschool children’s development, including their physical activity behaviors. However, there is a dearth of research focused on the promotion of children's physical activity within the family …
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THE EFFECT OF CONTRACTILE ACTIVITY AND SUBSTRATE CHALLENGES ON METABOLIC FLEXIBILITY IN HUMAN PRIMARY MYOTUBES
… in state 3 palmitoyl-carnitine malate (PCM₃) and FCCP stimulated respiration in response to all three substrates. Citrate synthase activity and OXPHOS protein content also increased whereas glucose utilization decreased in response to substrate challenges in both lean and obese groups. The …