Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"FC receptors"”.
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Localization of FC Receptors on Murine Spermatozoa.
Studies on the localization of acrosomal enzymes have shown that a heat stable component in non-immune serum binds to the acrosomal region of spermatozoa of a number of species (Weil and Finkler, 1959; Edwards, 1960). Beck et al. (1962) demonstrated by immunofluorescent techniques that this serum …
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The structures of secretory IgA in complex with human and bacterial Fc receptors and functional implications for mucosal host-pathogen interactions
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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The effect of manipulating apoptotic cell uptake on their immunogenicity
… second which re-directed apoptotic cells through Fc? receptors and conferred enhanced phagocytosis by both macrophages and immature dendritic cells (DN-MFG-E8-Fc) in a dose-dependent manner.<br/>Cross-presentation of cell-associated antigen by bone marrow-derived dendritic cells (BMDCs) was …
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Studies investigating peripheral blood derived cells that express the high affinity receptor for immunoglobulin E (Fc?RI) In Allergic Disorders
… biological actions through the binding of its Fc fragment to specific Fc receptors on effector cells. There are two predominant Fc receptors for IgE – Fc?RI, which has a very high affinity for IgE and Fc?RII, which shows less avid binding. For much of the first two decades after the …
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Studies investigating peripherial blood derived cells that express the high affinity receptor for immunoglobulin E (FceRI) in allergic disorders
… biological actions through the binding of its Fc fragment to specific Fc receptors on effector cells. There are two predominant Fc receptors for IgE – Fc?RI, which has a very high affinity for IgE and Fc?RII, which shows less avid binding. For much of the first two decades after the …
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Characterization of Fc receptor family proteins in vaginal and endocervical epithelia
… of my research project was to characterize Fc receptor expression in epithelial cell models of the lower female genital tract with a particular focus on the neonatal Fc receptor (FcRn). Fc receptors are a large family of proteins that bind to the Fc region of immunoglobulins (Igs) and …
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Antibody-Effector Functions in Antiviral Response
… of the antibody's fragment crystallizable (Fc) domain with Fc receptors (FcR) on effector leukocytes is essential for proper immunological function and bridges the humoral with the cellular components of immunity. While the Fc domain of immunoglobulin G (IgG) has historically been considered …
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Mediators of monocyte activity in inflammation
… shown to bind directly to monocytes through Fc receptors. However this observation is not conclusive and requires further investigation. The effects of incubation of CRP with human primary and monocytic cell lines were examined using monocytic cytokine expression, adhesion molecule expression …
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Microglia and Myelin: Improved Tools and Molecular Interactions
… constitutively active Cre line leveraging the Fcrlslocus. Most notably, flow cytometric analysis shows that this line completely spares monocytes and other white blood cells. Complementing Tmem119- EGFP and Tmem119-CreERT2 mice that have already been adopted by hundreds of labs, Fcrls-Cre mice …
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Tumor-induced immunosuppression: Contribution of a high molecular weight inhibitor and Prostaglandin E2
… mAb were reacting specifically and not via Fc receptors. Culture supernatants added to the MLR showed that the Mφ suppressor phenotype shifted from Mac-3⁺ in the normal host to Mac-2⁺ in the TBH. Production of PGE₂ was susceptible to indomethacin, but in general the relative production of …
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Discerning the Mechanism of Gamma Delta T Cell-Mediated Damage in Multiple Sclerosis: the Potential Role of Antibodies in Disease Pathogenesis
… In particular, some γδ T-cells that express Fc receptors (FcR), such as CD16, that bind antibody are more prominent with MS disease progression and have been shown to exert cytolysis via antibody-dependent cellular cytotoxicity (ADCC). We postulated that if there were also relevant and …
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HER2 and Folate Receptor Targeted Therapy is Enhanced by NK Cell-Activating Cytokines
… may depend on immune effector cells that express Fc receptors (FcR) for immunoglobulin G. Natural killer (NK) cells are innate immune effector cells that play a crucial role in cancer rejection and immunosurveillance. Importantly NK cells express the Fcgamma receptor IIIa (FcgammaRIIIa) and …
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Engineering novel antibody-based molecules to probe the role of the immunoglobulin hinge and generate a potential cancer vaccine
… the antigen-binding Fab region from the Fc region, varies considerably in length. The hinge region is believed to provide flexibility for the Ig to conduct better positioning for antigen binding via the Fab arms or better receptor association via the Fc region. However, the reason for the …
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Identification of the Role of P-Rex1 and its Adaptor Functions in Neutrophils
… particles and supports both integrin- and Fc receptor-dependent uptake independently of its Rac-GEF activity. Furthermore, P-Rex1 facilitates the Fc receptor-mediated activation of Rac and Syk. To investigate the underlying mechanism by which P-Rex1 mediates GPCR trafficking, we found that …
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TREM-2 and Dendritic Cells in the Pathogenesis of Allergic Airway Inflammation
… cells express several pattern recognition receptors (PRRs) that are critical for their function as sentinels of the immune system. DC maturation can be induced by several signaling pathways, such as TLR, Fc receptors and DAP-12 mediated -signaling, based on the activating signal. The …
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Studies of immunoglobulin receptors and human proximal tubular cells
… complex (Ig/IC) may involve specific cellular receptors, and thus provide a novel mechanism for the initiation of tubular injury and fibrosis. Deposition of Ig and IC is seen in renal diseases such as membranous glomerulonephritis, and IgAN. Ig/IC are regarded as responsible for the initiation …
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Fc Gamma Receptors Facilitate Antigenic Modulation of LILRB4 and Function as Predictive Biomarkers in Acute Monocytic Leukemia
… targeting this receptor, which makes use of an Fc gamma receptor scaffolding mechanism to interact with its target. This mechanism is specific to antibodies targeting cells of the hematopoietic lineage, which possess Fc gamma receptors. It has been described in the literature as antigenic …