Global ETD Search
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Showing 1 to 10 of 10 for “"FBXW7"”.
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The Novel Upstream Regulator of Fbxw7
<p>SCF<sup>FBXW7</sup> is a tumor suppressor E3 ligase protein that targets numerous oncoproteins such as Cyclin E, c-Myc, c-Jun and MCL1. The deregulation of these proteins often leads to the proliferation of cancer cells. Thus, intracellular stability and functional activity of FBXW7 is critical …
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Estudio de la ubicuitilación del complejo MRN mediada por SCF(bTrCP/FBXW7): implicaciones biológicas
… F-box más destacadas de SCF son TrCP y FBXW7. Ambas son responsables de la ubicuitilación de una gran variedad de sustratos implicados en múltiples procesos celulares, y tanto estos como dichas proteínas F-box se han relacionado con diferentes aspectos de la transformación tumoral. En …
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Fbxw7 Triggers Degradation Of Kmt2d To Favor Growth Of Mature B-Type Malignant Cells
… Here, we assessed the role of the UPS E3 ligase FBXW7 in mature B-cell neoplasms. Coupling proteomic screens and biochemistry, we report for the first time that FBXW7 is an E3 ligase for the lysine methyltransferase KMT2D. We show that FBXW7 utilizes its conserved WD40 domain to interact with …
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Suppression of the Ubiquitin Ligase Function of FBXW7 Accelerates Metastatic Progression of Pancreatic Ductal Adenocarcinoma
… of protein degradation is the tumor suppressor FBXW7, a substrate recognition domain of the SCF E3 ubiquitin ligase, frequently dysregulated in many cancers. The function and clinical significance of FBXW7 in pancreatic cancer has been studied in some detail. Pancreatic cancer patients with low …
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Genome-wide CRISPR Screening in FBXW7-mutant Cells Uncovers Multiple Druggable Synthetic Lethal Interactions Involving Cell Cycle Control
… the commonly mutated tumour suppressor gene, FBXW7. We first identified that FBXW7-/- cells require CCNL1 for growth, and discovered that CCNL1 is a novel substrate of FBXW7, tasked with a role controlling progression through mitosis. FBXW7-/- cells, due to their requirement of CCNL1, were …
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Molecular and biochemical characterisation of phosphorylation-dependent NICD1 turnover: novel roles for CDK1 and CDK2
… and GSK-3β, which then recruits the SCF Sel10/FBXW7 E3 ubiquitin ligase complex, that targets NICD for degradation by the proteasome. However, many of these studies have been conducted through overexpression assays in vitro and none of this regulation has been verified in the presomitic …
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Identification of Tissue and Circulating Biomarkers For Premalignant and Malignant Lesions
… genes (<em>TP53, KRAS, APC, PIK3CA, SMAD4, FBXW7, CTNNB1, SYNE1, CDC27, CSMD1, NRAS, RYR3, NALCN, LRP1B, FAT4, ATM, TMPRSS13, SOX9, CSMD3, MED12</em>) which constantly served to separate adenomas from adenocarcinomas were discovered.</p> <p>The Second project focused on exploring …
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Prevalence and fate of pro-oncogenic clones in the human colon
… cancer driver genes; ARID1A, APC, CTNNB1, FBXW7, KRAS, PTEN, TP53 and SMAD4. Losses or gain of function in these genes were associated with biases in the processes of clone fixation and expansion, which determined their event burden in the tissue. However, by comparing the event burden in …
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Elucidating the Multi-omics of Early-Onset Colorectal Cancer
… MSS, including significant co-occurrences of FBXW7 with NOTCH3, RB1, and PIK3R1. This study highlights the significance of age-specific molecular profiling, offering insights into the unique biology of EOCRC and potential clinical applications.</p>