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Showing 1 to 6 of 6 for “"FBXO7"”.
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Signalling pathway of FBXO7 and its role in hereditary Parkinsonism
… new treatment strategies.<br/>Mutations in the FBXO7 gene have recently been shown to cause an autosomal recessive early onset Parkinsonian-pyramidal syndrome and FBXO7 has been designated as PARK 15 (Di Fonzo et al., 2009). FBXO7 is a member of the F-box protein family, which functions as the …
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Post-translational control of mitochondria by Fbxo7 in Parkinson's disease
… genes. In 2008, mutations in the gene FBXO7 were identified as causing early-onset Parkinsonian pyramidal syndrome. Fbxo7’s canonical function is as the substrate recruiting domain of an E3 SCF ubiquitin ligase complex. Mitochondrial defects have previously been detected in cells …
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The Role of FBXO7 in Mitochondrial Biology and Parkinson's Disease
… symptoms. Autosomal recessive mutations in the FBXO7 gene have been identified to cause a rapidly progressing early-onset form of PD. Canonically, FBXO7 functions as a substrate-recruiting subunit of the SCF-type E3 ubiquitin ligase. However, it also has a variety of other atypical functions, …
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The discovery of a role of FBXO7/PARK15 in intracellular trafficking
… models expressing PARK-gene mutations. PARK15/FBXO7 encodes the F-box protein Fbxo7, which has a wide range of functions both as the substrate recruiting subunit of a Skp1-Cullin1-F-box (SCF) E3 Ubiquitin ligase complex and independent of SCF-binding. Known functions of Fbxo7 include regulation …
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STRUCTURAL AND FUNCTIONAL STUDIES OF F-BOX-ONLY PROTEIN FBXO7 AND ITS INTERACTIONS WITH PROTEASOME INHIBITOR PI31
F-box only protein 7 (Fbxo7), a member of the F-box-only subfamily of FBPs, is a biologically and pathophysiologically important human protein that assumes many critical functions. The different functions of Fbxo7 depend on the formation of various multi-protein complexes. Possible interplay …
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Ubiquitination of proteins involved in metabolism and immunomodulatory drug sensitivity in lymphocytes
… promoting ubiquitination, the F-box protein Fbxo7 can also function as a scaffold and stabilise a subset of proteins, including Cdk6. Cdk6 is activated through binding the D-type cyclins, and historically, a key role has been as a cell cycle regulatory kinase that inactivates G1 checkpoint …