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Showing 1 to 3 of 3 for “"FBXL21"”.
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The Gsk-3Β-Fbxl21 Axis Regulates Tcap Via Ubiquitin-Mediated Proteasomal Pathway In The Cytoplasm
… F-Box and Leucine Rich Repeat Protein21 (FBXL21) is a circadian E3 ligase which shows oscillatory mRNA transcripts and protein levels. It was previously found to perform subcellular compartment-specific E3 ligase activities targeting the core clock proteins CRYPTOCHROME(CRY)1/2. Here we …
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The Role of Two Homologous E3 Ligases In Muscle Physiology
… significance often remains unknown. FBXL3 and FBXL21 are two homologous E3 ligases that have previously been reported to dictate circadian periodicity, with FBXL3 being the dominant E3 ligase and FBXL21 playing a regulatory role. A recent Yeast Two-Hybrid screen revealed a new shared target of …
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THE ROLE of THE CIRCADIAN CLOCK IN DISEASE and TISSUE FUNCTION
… regulation in the skeletal muscle through FBXL21-mediated TCAP degradation. <em>Psttm</em>, or FBXL21 loss of function mutant, affected TCAP oscillation and inhibited TCAP degradation. GSK-3β acts as an upstream kinase regulating TCAP degradation and activating FBXL21 E3 ligase function. …