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Showing 1 to 4 of 4 for “"FBW7"”.
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Regulation of Substrate Degradation and Cancer Metabolism by the Fbw7 Ubiquitin Ligase
Fbw7 is the substrate binding subunit of an SCF E3 ubiquitin ligase, which catalyzes the polyubiquitylation of substrates, initiating their recognition and degradation by the proteasome. The affinity of Fbw7 for its substrates is substantially increased following substrate phosphorylation at …
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Ehrlichia chaffeensis E3 Ligase TRP120 Ubiquitinates Tumor Suppressor FBW7 for Degradation to Promote Infection
… F-BOX and WD domain repeating-containing 7 (FBW7). FBW7 is the substrate recognition subunit of the Skp1-cullin-1-FBOX E3 ubiquitin (Ub) ligase complex (SCF) known to negatively regulate a network of oncoproteins (Notch, cyclin E, c-Jun, MCL1 and cMYC). In this study, we demonstrate that …
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Molecular And Therapeutic Implications Of Notch1 Signaling In Pediatric T-Cell Acute Lymphoblastic Leukemia
… We explored the impact of mutations in NOTCH1, FBW7 and PTEN on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia. We identified a high frequency of mutations in NOTCH1 (16 patients), FBW7 (5 patients) and PTEN (26 patients) in a well defined cohort of 47 …
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Determinants of GATA1-mediated gene regulation during erythroid maturation
… stages of hematopoiesis, by GATA1. We show that Fbw7, an ubiquitin ligase protein trans-activated by GATA1, targets GATA2 for proteosomal degradation, thus reducing its halflife and leading to more efficient GATA factor switching. Finally, in a last section, we characterize the GATA1 -interacting …