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Showing 1 to 20 of 70 for “"FATTY ACID METABOLISM"”.
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Fatty acid metabolism of marine microalgae
Pathways for the biosynthesis of docosahexaenoic acid (DHA) and other polyunsaturated fatty acids (PUFA) were elucidated in two heterotrophic, marine microalgae; Schizochytrium sp. and Crypthecodinium cohnii. PUFA-requiring auxotrophs of both of these algae were created and used as tools for …
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Regulation of Highly Unsaturated Fatty Acid Metabolism
… are considered as the main regulators of fatty acid oxidation and synthesis, respectively, including metabolism of highly unsaturated fatty acids (HUFAs). The objective of the first project was to investigate functional differences of PPARalpha between species. PPARalpha is essential for …
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Effects of carnitine on medium-chain fatty acid metabolism in newborn pigs
Metabolism of medium-chain fatty acids (MCFA) is considered to be independent of carnitine because of their passive diffusion into the mitochondrion. However, upon feeding medium-chain triglycerides (MCT) to piglets (n = 16) followed by serial blood sampling, we observed significant changes in free …
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Modular pathway engineering of microbial fatty acid metabolism for the synthesis of branched acids, alcohols, and alkanes
… Here we report the engineering of microbial fatty acid synthesis to provide both CoA-dependent and fatty acid synthase platforms for previously undescribed routes to medium-chain length, branched acids. Specifically we produced six-carbon 4-methyl-valeric acid via a CoA-dependent route and …
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Control of bovine Pyruvate Carboxylase Expression by Saturated and Unsaturated Fatty Acids and Impact on Fatty Acid Metabolism
… 6.4.1.1) ostensibly links carbohydrate and lipid metabolism by supplying oxaloacetate (OAA) from the carboxylation of pyruvate. The OAA pool is necessary in maintaining the anaplerotic supply of carbons to the TCA cycle, and to promote the complete oxidation, to CO2, of acetyl-CoA. The actions of …
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Effect of Alpha-Tocopherol on Essential Fatty Acid Metabolism in Liver Mitochondria Obtained From Chicks Suffering From Encephalomalacia
Made available in DSpace on 2014-12-05T19:06:51Z (GMT). No. of bitstreams: 1 6206179.pdf: 2646256 bytes, checksum: 04b4d285b9ba5bb084dc02570db12eb9 (MD5) Previous issue date: 1962
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Fatty acid metabolism and SNPs related to obesity in a longitudinal study of Swedish men: Predictors of metabolic syndrome
… The variables reflecting metabolic health were fatty acid (FA) variables, fasting blood glucose, abdominal skinfold thickness, lipids and lipoproteins, and blood pressure in the ULSAM cohort at age 50. Secondly, to investigate to what extent SNPs, that significantly are associated with metabolic …
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Effects of maturation, polyploidy, and nutrition on growth, composition, and gene expression within fatty acid metabolism in rainbow trout
… individuals; however, differences in lipid metabolism of female diploid (2N) and triploid (3N) trout may alter fillet quality. In addition, there is concern that genetic selection for increased growth negatively impacts fillet quality and muscle lipid content. Research in these areas would …
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The Role of Sleep in Memory Consolidation with an Induced Sleep-Like State in Drosophila AND The Role of Alpha-synuclein in Fatty Acid Metabolism
… memory.</p><p>The Role of Alpha-synuclein in Fatty Acid Metabolism</p><p>Introduction: Accumulation of aggregated alpha-synuclein protein is the defining pathologic feature of Parkinson's disease (PD). However, the molecular mechanisms underlying protein aggregation remain to be defined. …
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The Role of Fatty Acids on Toll-like Receptor 4 Regulation of Substrate Metabolism with Obesity
… of obese humans and is associated with reduced fatty acid (FA) oxidation and increased lipid synthesis. Additionally, activation of this pathway by lipopolysaccharide (LPS), ex vivo, results in a shift in substrate metabolism favoring glucose as an energy substrate and preferential storage of FA …
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Studies of Lipoic Acid Related Enzymes
… that shared high homology with medium chain fatty acid-CoA ligases. I expressed the His-tagged protein at a high level in E. coli and purified it to homogeneity. To explore the physiological application of this enzyme in E. coli fatty acid metabolism, I constructed the first E. coli fabH …
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Nutritional factors influencing tissue omega-3 metabolism and endocannabinoids levels in experimental models and humans
The nutritional role of dietary fatty acids is quite controversial and often the object of mediatic campaigns either as panacea against all diseases or detrimental for human health. The most recent data are instead showing that it should be considered, in an optimal dietary regimen, the balance …
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Dry Period Nutrition and Hepatic Metabolism of Fatty Acids and Glucose in Transition Dairy Cows
… of far-off and close-up diets on palmitate metabolism in vitro. During the far-off period, d -60 to -25, cows received a low energy control diet fed ad libitum (100NRC) to meet National Research Council (2001) nutrient requirements, a moderate-energy diet fed ad libitum to exceed NRC …
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Hypoxia, Lipid Signalling and Tissue Metabolism in Obesity-Related Metabolic Disease
… progression of metabolic dysregulation. As lipid metabolism is highly dependent on oxygen tension, this work aimed to investigate the links between hypoxia and altered tissue metabolism accompanying the progression of obesity-related metabolic disease, with a particular focus on lipid metabolism. …
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Microrna involvement in hepatic adaption during the periparturient period in Holstein dairy cows
… disorders like oxidative stress, ketosis, and fatty liver. Two experiments were conducted to evaluate 1) hepatic microRNA (miRNA) involvement in periparturient Holstein dairy cows supplemented methionine and 2) how body condition score (BCS) in late pregnancy impacts hepatic biomarkers involved …
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Molecular Classification of Basal Cell Carcinoma of Skin by Gene Expression Profiling
… of metabolic processes particularly the fatty acid metabolism. The existence of these molecular subtypes could be validated in an independent dataset, which demonstrated the three subgroups of BCC with distinct functional enrichment. In conclusion, we suggest a novel molecular …
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The roles of orphan nuclear receptors, SHP and FXR, and their cofactors in bile acid signaling
Bile acids, the end-product of cholesterol catabolism, are important for absorption and solubilization of lipids in the intestine because of their detergent properties. In addition to their roles as detergents, previous studies have revealed that bile acids function as signaling molecules in …
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Analysis of lipid metabolism regulators in breast cancer cells after induction of the Epithelial to Mesenchymal Transition
… and conferred tumor recurrence. Although metabolism plays a fundamental role in essentially every function of a cell, little is known about how the EMT programme involves in regulating cell’s metabolism contributes to the morphological and molecular changes. An early and universal feature …
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