Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"FASCIOLA HEPATICA"”.
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Fasciola hepatica cystatins: recombinant production, biochemical characterisation and efficacy as vaccines
… with the digenetic trematode (flatworm) Fasciola hepatica, is of major global economic importance in ruminants, such as cattle and sheep, and is now recognised as an important zoonosis. Following ingestion by the mammalian host, the parasite migrates through the intestinal wall and …
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Post-genomic studies on the neuropeptide signalling system of Juvenile <i>Fasciola hepatica</i>
The flatworm Fasciola hepatica is a globally significant parasite in terms of agricultural productivity and human health. This thesis investigated the role of the neuropeptide signalling system in the biology of this species. Advances in genomic and transcriptomic resources facilitated the …
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The cellular and molecular origins of extracellular vesicles secreted by <i>Fasciola hepatica</i>
… raised against proteins enriched in <i>F. hepatica</i> (Fh)EVs were used to identify their cellular origins in adult flukes. This analysis revealed multiple sites of FhEV production (the parenchyma, tegument, gastrodermal cells and protonephridial system) and indicated that further subtypes …
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Characterisation of the Fasciola hepatica miRNome and an evaluation of its role in the host-parasite relationship
The liver fluke, Fasciola hepatica, is recognised as one of the most successful parasites worldwide due to its remarkable capacity to infect every mammal it encounters. For this reason, liver fluke disease, or fasciolosis, has the widest geographical spread of any parasite disease and contributes …
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Liver fluke development: a target for parasite control?
… by flatworm parasites belonging to the genus Fasciola, is a prominent threat to global food security due to its widespread infection of agriculturally significant ruminants. Recent studies have identified a population of proliferative cells within Fasciola hepatica (Fasciola proliferative …
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The immunomodulatory properties of helminth-derived products on dendritic cell maturation and function
… products derived from the helminth parasites Fasciola hepatica and Ascaris lumbricoides we investigated the mechanism by which these responses are induced. Dendritic cells (DC’s) play a crucial role in linking the innate to adaptive arms of the immune system and directing the subsequent immune …
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Využití metod hmotnostní spektrometrie v identifikaci a lokalizaci významných molekul parazitických helmintů
… na proteiny a fasciolidní motolice (např. Fasciola hepatica). Druhá část práce se věnuje identifikaci a lokalizaci molekul pomocí zobrazovací hmotnostní spektrometrie a využití této techniky v experimentální biologii, parazitologii. V závěru práce je navržen aplikovatelný postup pro …
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Modulation of macrophage function and immune response by a helminth-derived cysteine protease
… the ES products of the liver fluke trematode, Fasciola hepatica, have been shown to prevent autoimmune type 1 diabetes in a murine model (Lund et al. in preparation). Disease prevention was associated with the initiation and perpetuation of anti-inflammatory/regulatory immune responses, …
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Untersuchungen zum Zeckenbefall und zur Prävalenz von Borrelia burgdorferi sowie Babesia divergens beim Rind im bayerischen Voralpenland
… tested for the presence of antibodies against Fasciola hepatica. In 96,8 % of the farms antibodies against Fasciola hepatica could be detected.
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The synthesis, structural characterization and biological evaluation of potential chemotherapeutic agents
… greater inhibitory potency on the liver fluke Fasciola hepatica cysteine cathepsin L like endoproteases over the known commercial inhibitor Z-Phe-Ala-CHN₂ at varying concentrations. The synthesis, structural characterisation and biological evaluation of a series of analogues of this active …
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Linking environmental variation across the Scottish Highlands with red deer (Cervus elaphus) trace element status, parasite burden, and skeletal morphometry
… (FEC) method for quantification of liver fluke (Fasciola hepatica) prevalence in Scottish Highland red deer.<br/>2. Reveal substantial geographic variation in the prevalence of F. hepatica in wild red deer in the Scottish Highlands, and that an individual’s probability of infection: i) associates …
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Using post-genomics technologies to advance understanding of liver fluke therapeutics
Fasciola spp have significant impacts on human and animal health worldwide and are estimated to cost the agri-food industry billions of US$ every year. The treatment of fascioliasis/fasciolosis relies heavily on Triclabendazole (TCBZ), the only flukicide active against immature and mature stages of …
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Probing the biology of liver fluke-flukicide interplay
… caused by liver fluke parasites of genus Fasciola, is responsible for reducing global agricultural yield in livestock animals and is a neglected tropical disease of humans. A limited portfolio of flukicide drugs are available, however treatment of the highly pathogenic acute stage is …
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The development of the rumen fluke, Calicophoron daubneyi, within the mammalian host
… in pH and hypochlorite concentrations than Fasciola hepatica eggs suggesting that their atypical eggshell composition/crosslinking biochemistry may confer additional structural stability in changing environmental conditions. The findings described here provide a framework for detailed …
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