Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"FAP"”.
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Funktionelle Untersuchungen zum Einfluss von FAP-Inhibitoren auf die Tumorzellmigration und Invasion
Das Fibroblasten-Aktivierungs-Protein (FAP) ist eine Oberflaechenprotease mit kollagenolytischer Aktivität in vitro, die in vivo spezifisch von Fibroblasten in der Umgebung maligner epithelialer Tumoren in der Phase der Invasion und Disseminierung aufreguliert wird. Da Matrixproteasen durch …
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Σύνθεση, Ραδιοεπισήμανση και Αξιολόγηση παραγώγων Λιναγλιπτίνης με 68Ga, 99mTc, 111In και 203Pb ως Νέων Ραδιοφαρμακευτικών Παραγόντων Στόχευσης της FAP
… της προς την πρωτεΐνη ενεργοποίησης ινοβλαστών (FAP), η οποία αποτελεί σημαντικό μοριακό στόχο στη ραδιοφαρμακευτική έρευνα. Για τον σκοπό αυτό, πραγματοποιήθηκε σύζευξη της λιναγλιπτίνης με τους χηλικούς παράγοντες DOTA και NOTA, μέσω αντίδρασης με τους αντίστοιχους ενεργοποιημένους NHS-εστέρες. …
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Investigating the fibroblast activation protein alpha expressing stromal cell in a spontaneous murine model of pancreatic adenocarcinoma
… marked by fibroblast activation protein alpha (FAP) mediates local immune suppression in transplantable tumour models. Such models however do not always reflect the biology of human cancer. The following work investigates whether FAP+ cells modulate the immune response in a more physiological …
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Finding Common Ground to Treat Primary and Metastatic Cancer: The Potential of Targeting Tumor Stroma
… disease. Fibroblast activation protein (FAP) is a membrane surface protease found overexpressed in cancer-associated stromal cells. Overexpression of FAP is associated with tumor progression, metastasis and recurrence, and predicts a poorer prognosis in many types of human tumors. The …
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Availability of Dental Anomaly Phenotype In Individuals With Familial Adenomatous Polyposis
… gene cause familial adenomatous polyposis (FAP), an autosomal dominant colorectal cancer predisposition associated with the development of hundreds to thousands of adenomatous colorectal polyps beginning in childhood or adolescence. Both malignant and non-malignant extracolonic …
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Targeting the Tumor Stroma Using a Monoclonal Antibody Platform Technology
… shows fibroblast activation protein alpha (FAP) is a relevant target for imaging and treating mCRPC. FAP is emerging as the next pan-cancer target given its upregulated expression in cancer associated fibroblasts (CAFs) and localization to the tumor microenvironment. Here we document the …
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Fibroblast Heterogeneity In Pancreatic Cancer Immunity
… CAF subsets defined by expression of aSMA and FAP.</p> <p>We employed single cell RNA sequencing, mass cytometry, and multiplex immunohistochemistry to assess genetically engineered mouse models (GEMMs) in which we could deplete aSMA<sup>+</sup> and FAP<sup>+</sup> CAFs. We found the …
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Análise do programa de aquisição de alimentos (paa) na comunidade negra de Camará
… their products. The Food Acquisition Program (FAP) is one of the actions executed by Zero Hunger Program. It aims at ensuring people to have access to food, and also help the farmers to sell their products from family farming. Thereby, the farmers are helped to face difficulties related to …
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Food sovereignty’s potential to address poverty and hunger by creating sustainable peasant led agri-food systems: a case study from the Brazilian food acquisition programme in Mirandiba, Pernambuco
… government’s Food Acquisition Programme (FAP), as implemented in Mirandiba, Pernambuco by the NGO Conviver from 2005-2008. The analysis involved an assessment of the production and earnings by 359 participating families from 18 poor rural communities, as well as detailed case studies of …
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Assessing Parental Attitudes Towards Hepatoblatosma Screening
<p>OBJECTIVES: Familial adenomatous polyposis (FAP) is an autosomal dominant cancer predisposition syndrome with nearly a 100% lifetime risk of developing colorectal cancer, if left untreated. Children with FAP have up to a 2% risk for the development of hepatoblastoma (HB). Guidelines for HB …
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Interference Aware Cognitive Femtocell Networks
Femtocells Access Points (FAP) are low power, plug and play home base stations which are designed to extend the cellular radio range in indoor environments where macrocell coverage is generally poor. They offer significant increases in data rates over a short range, enabling high speed wireless and …
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Genomic Characterization of Polyps In Familial Adenomatous Polyposis Patients and Identification of Candidate Chemopreventive Drugs
<p><em>Familial adenomatous polyposis</em> (FAP) is an autosomal dominant disease characterized by <em>APC</em> germline mutations and the development of hundreds to thousands of premalignant adenomas in the gastrointestinal tract at a young age. If left untreated, these patients inevitably develop …
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Understanding Psychosocial Treatment Non-Response in Children with Functional Abdominal Pain
<p>Functional abdominal pain (FAP) is a commonly occurring gastrointestinal disorder in children and adolescents. It is associated with significant distress and impairment for both children and caregivers. Psychosocial treatments have been shown to effectively treat FAP and related outcomes. …
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Mixed-ligand diruthenium complexes: theoretical modelling and interpretation of electronic absorption spectra
… and improved solubility of Ru₂(μ-O₂CCH₃)₃(μ-2-Fap)X complexes, where 2-Fap is 2-(2-fluoroanilino)pyridinate, and X represents Cl, Br or I, are influenced by the axial ligand (X) lability and solvent coordination at the axial site. These complexes have Ru(II) and Ru(III) metal centers that can …
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Works of Art, Arts for Work: Caroline Wogan Durieux, the Works Progress Administration, and the U.S. State Department
… a New Orleans artist, WPA Federal Art Project (FAP) administrator, and representative for the United States' State Department, centering upon Durieux's career from 1917 to 1943. Durieux's work with the FAP, and later the State Department, helped to redefine the role of art in American society by …
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Composite propellant combustion with low aluminum agglomeration
… binder matrix highly loaded with fine (2-µm) AP (FAP) at 75/25:FAP/binder (by mass) is found to have premixed flame conditions that produce minimal agglomeration (without ignition) of 15-µm Al. Coarse AP (CAP) is added to the system in the form of either particles (200 or 400 µm) or pressed-AP …
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Blocking Immunosuppressive Factors and Taking Advantage of the Nutrient Supply Within the Tumor Microenvironment: Pathways to Achieve Improved Cancer Immunotherapeutic Efficacy for Patients With Metastatic Melanoma
… targeting the fibroblast activation protein (FAP), which is expressed at high levels on tumor-stromal fibroblasts. Combining the vaccines to FAP and MAAs significantly improves the survival of tumor-bearing mice. This is caused by destruction of FAP+ cells, which reduces frequencies and …
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The molecular genetic and epidemiological investigation of colorectal cancer in South Africa
… feature (e.g. familal adenomatous polyposis-FAP) and the non-polypotic forms (e.g. hereditary nonpolyposis colorectal cancers-HNPCC).
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ASSESSMENT OF RELEVANT MOLECULAR TARGETS WITH THERAPEUTIC SIGNIFICANCE IN CANINE NEOPLASMS.
… cells and in the tumor microenvironment: FAP, EDB+FN, KIT (CD117), PDGFR-β, and OXTR. These molecules are involved in tumor progression, stromal remodeling, angiogenesis, and hormonal regulation. Results confirm that canine tumors can harbor multiple therapeutically relevant molecular …
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Halogen-element (F, Cl, and Br) behaviour in apatites, scapolite, and sodalite : an experimental investigation with field applications
… partitioning experiments between fluorapatite (FAP) /chlorapatite (ClAP) and coexisting melts were conducted in the system of CaO-P2O5-CaF2-CaCl2–NaBr at 1120 degree C to 1400 degree C and atmospheric pressure. The partition coefficients (D) with errors of 1 sigma in parentheses are as follow: …
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