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Showing 1 to 4 of 4 for “"FANCD2-FANCI"”.
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The p97 cofactors UBXN7 and UBXN8 interact with and modulate the function of cullin-RING complexes and Fanconi anaemia proteins FANCD2/FANCI, respectively
… proteins, including the Fanconi anaemia proteins FANCD2 and FANCI. I could show that homodimeric UBXN8 interacts directly with non-ubiquitylated FANCD2 and FANCI. The direct binding of UBXN8 to the non-ubiquitylated FA proteins supports the notion that UBX-only proteins interact with substrates in …
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Separate Roles of FAN1 and Fanconi Anemia Proteins in DNA Interstrand Crosslink Repair and Human Disease
… steps. Here, we assessed the contributions of FANCD2/FANCI-Associated Nuclease 1 (FAN1) to the repair of ICL lesions and studied the consequences of its deficiency, which results in rare chronic kidney disease - Karyomegalic Interstitial Nephritis (KIN). FAN1 is a highly conserved nuclease from …
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Defining the role of endonuclease VIII-like 1 and 3 in the repair of interstrand crosslinks in cancer cells
… NEIL1 or NEIL3 expression in cell lines lacking FANCD2, of the monoubiquitinated DNA-heterodimer protein complex FANCD2/FANCI, could significantly affect their sensitivity to ICL-inducing agents, such as mitomycin C and cisplatin. An FA original and two FA-generated cancerous cell model systems …
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Structural and Biochemical Investigation of Fanconi Anemia Pathway Activation
… and repairs DNA ICLs. Ubiquitination of the FANCD2-FANCI (D2-I) complex by a multi-subunit ubiquitin E3 ligase, the FA core complex, is a key step of the FA pathway. D2-I ubiquitination initiates ICL repair by recruiting endonucleases to remove the DNA lesion, which is subsequently repaired …