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Showing 1 to 2 of 2 for “"FAN1"”.
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New Insights into the Roles of FAN1 Nuclease in Genome Maintenance and Disease
… threats. FANCD2 and FANCI associated nuclease 1 (FAN1) has roles in protection against two major threats to genomic stability: DNA interstrand crosslinks (ICLs), and the expansion of trinucleotide repeats. ICLs are highly deleterious lesions that disrupt replication, are destructive to dividing …
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Separate Roles of FAN1 and Fanconi Anemia Proteins in DNA Interstrand Crosslink Repair and Human Disease
… of FANCD2/FANCI-Associated Nuclease 1 (FAN1) to the repair of ICL lesions and studied the consequences of its deficiency, which results in rare chronic kidney disease - Karyomegalic Interstitial Nephritis (KIN). FAN1 is a highly conserved nuclease from yeast to humans. It was first …