Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 89 for “"FAK"”.
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Structural-based Investigation of FAK and P130Cas in Focal Adhesion
… directly interact with Focal Adhesion Kinase (FAK), which is a non-receptor tyrosine kinase that prominently locates in FAs. FAK serves the dual functions of recruiting p130Cas to FAs and recruiting Src kinase to phosphorylate the p130Cas substrate domain (SD) to promote downstream signaling. …
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Metastatic Reactivation and Progression Result From Fak-Mediated Disruption of Innate Immune Signaling
… Here, we identify focal adhesion kinase (Fak) as a critical regulator of metastatic reactivation and progression and describe a novel mechanism by which it facilitates immune evasion. Fak ablates stimulator of interferon genes (Sting)-dependent type I interferon production when DTCs awaken …
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Microrna-200 Regulates Ecm-Dependent Β1-Integrin/Fak Signaling and Cancer Cell Invasion
… the cells responsiveness to the ECM through the FAK/Src pathway. The importance of this pathway in our Kras and p53 mouse model and in human lung cancer cell lines was further studied using pharmacological inhibitors and an shRNA-based knockdown approach, which exhibited a significant suppression …
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REGULATION OF RHOGAP DLC1 BY FAK, PP2A AND MEK/ERK IN CELL DYNAMICS
… of Ras/Mek/Erk pathway, Focal adhesion kinase (FAK) and Protein phosphatase-2A (PP2A) to activate DLC1s GAP function. EGF stimulation not only leads to the phosphorylation of DLC1 but also that of FAK to inactivate it, thus allowing PP2A-mediated dephosphorylation at a secondary site on DLC1. …
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Soft 3D fibrin matrices downregulate FAK expression to promote self-renewal of tumor-repopulating cells
… this study we show that focal adhesion kinase (FAK) regulates Sox2 expression and H3K9 de-methylation through cell division control protein 42 homolog (Cdc42). In comparison to control melanoma cells, TRCs exhibit low FAK and Cdc42 expression. Overexpressing FAK or Cdc42 in TRCs cultured in soft …
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Fluorescence resonance energy transfer-based subcellular visualization of FAK/Src activation by chemical and mechanical environment
… dynamics. Src and focal adhesion kinase (FAK) are key signaling molecules involved in these processes during growth cone dynamics and cell migration, and furthermore the progression of diseases such as cancer. Upon various chemical and mechanical environmental factors, Src and FAK can be …
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Effects of Penfluridol On Integrin-Fak Signaling and Tumor Cell Killing In Combination With Oncolytic Hsv In Glioblastoma
… pathways, one of which is focal adhesion kinase (FAK). Phosphorylation of FAK can lead to the activation of various downstream signaling pathways that can increase tumor cell growth and proliferation, making it an ideal target for cancer therapeutics. Due to the fact that many FAK inhibitors are …
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OMICs based identification of the mechanisms that underpin FAK’s regulation of gene expression
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase, commonly overexpressed in cancer that is well known to be a key regulator of cancer cell proliferation, survival, migration and invasion. It has recently been shown to modulate the antitumour immune response via transcriptional …
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Serine 910 Phosphorylation of Focal Adhesion Kinase Is Critical for Costamere Assembly
<p>Tyrosine-phosphorylated FAK is required for the hypertrophic response of cardiomyocytes to growth factors and mechanical load, but the role of FAK serine phosphorylation in this process is unknown. Endothelin-1 (ET-1; 1-100nM, 2-30min) and other hypertrophic factors induced a time- and …
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Marcadores moleculares de progresión en las lesiones premalignas de laringe
… del patrón de expresión de cortactina (CTTN), FAK y podoplanina durante el desarrollo y progresión de los carcinomas de laringe, así como la frecuencia de amplificación génica de CTTN y FAK, para establecer su papel en el proceso de transformación maligna. Se analizó mediante inmunohistoquímica …
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A role for focal adhesion kinase in the contraction of gastric fundus smooth muscle evoked by cholinergic neurotransmission
… the extracellular matrix. Focal adhesion kinase (FAK) regulates the recruitment and assembly of focal adhesion proteins. It has been established that integrin proteins and FAK play important roles in cell adhesion, tension generation, and mechanotransduction. Integrins and FAK are abundant in …
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Σηματοδοτικοί μηχανισμοί κατά την απόπτωση και την κυτταροφαγία στα αιμοκύτταρα της μύγας της Μεσογείου
… σοκ). Η έκφραση και φωσφορυλίωση των κινασών FAK, Src, ERK, PI-3K και Akt εξαρτάται από τo στάδιο ανάπτυξης, ενώ το μέγιστο της έκφρασης και φωσφορυλίωσής τους παρατηρείται στο στάδιο της λευκής νύμφης, όπου σημειώνεται και το μέγιστο της απόπτωσης. Η απόπτωση φαίνεται να επηρεάζεται από τα …
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Focal adhesion kinase, a major regulator of oligodendrocyte morphological maturation and myelination
… signaling, namely, focal adhesion kinase (FAK), during oligodendrocyte morphological maturation in vivo and in vitro. Conditional and inducible FAK-knockout mice (Fakflox/flox: PLP/CreERT mice) were generated to observe the effect of FAK loss on myelination in vivo. The role of FAK during …
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Role of Phosphorylation of Focal Adhesion Kinase At Tyrosine 861 In Prostate Cancer Metastasis
<p>Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that mediates interactions between the extracellular matrix and intracellular signaling pathways critical in promoting numerous cellular functions including adhesion, proliferation, survival and migration. Most FAK functions result …
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LRRK2 Regulates Actin Dynamics in ADP-Treated Microglia
… LRRK2 interacted with focal adhesion kinase (FAK), a protein that regulates the adhesion and migration of cells. LRRK2 and FAK were co-localized with ruffles when microglia actively moved. The overexpression of LRRK2 reduced the phosphorylated FAK levels compared with that of the mock, which …
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Integrin alpha(v) and Focal adhesion kinase - promising targets to limit smooth muscle cell migration
… wie auch durch die endogene Überexpression eines FAK Inhibitors, der über ein AAV Vektorsystem übertragen wurde, gehemmt werden konnte. So stellt die Blockade der Integrin vermittelten Signalkaskaden ein vielversprechendes Ziel für die Inhibition der Restenose nach PTCA dar. Im ersten Teil der …
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The role of mechanical loading in chondrocyte signaling pathways
… kinases such as Src and focal adhesion kinase (FAK) are known to play a crucial role in OA progression. We hypothesized that mechanical loading regulates the sub-cellular activation pattern of Src/FAK, and acts as a suppressor of the OA- or inflammatory cytokine-driven signaling activities. We …
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Integrin-vermittelte Invasion von Staphylococcus aureus in Säugerzellen
… Signalenzymen wie der Fokalen Adhäsions Kinase (FAK) oder Kinasen der Src Familie. Die Protein Tyrosin Kinase (PTK) FAK ist nach Integrinstimulierung eines der Schlüsselenzyme in FK. Dies war der Anlass nach der Bedeutung von FAK für die Integrin-vermittelte Internalisierung von S. aureus zu …
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