Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"FAERS"”.
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Translational high-dimesional drug interaction discovery and validation using health record databases and pharmacokinetics models
… risk of myopathy were identified in the FAERS and EMR databases by a mixture drug-count response model (MDCM) model. Twenty-eight 3-way and 43 4-way DDI’s increased ratio of area under plasma concentration–time curve (AUCR) >2-fold and had significant myopathy risk in both databases. The …
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An Economic and Regulatory Analysis of Gene Therapy Products Authorized by the US Food and Drug Administration and the European Medicines Agency
… to the FDA Adverse Event Reporting System (FAERS), and assessed the cost-effectiveness analysis of three gene therapies axicabtagene ciloleucel(axi-cel), lisocabtagene maraleucel (liso-cel), and tisagenlecleucel (tisa-cel).</p> <p>Research Design: For aim 1; data was collected using …
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Incidence of adverse drug events in COVID-19 patients on anticoagulants: a pharmacovigilance study
… from the FDA’s Adverse Event Reporting System (FAERS) Public Database. Chi-square test of association was performed to determine associations of race, sex and hospitalization rate with the adverse outcome variables. Proportional Reporting Ratios (PRR) and lower 95% confidence intervals (Lower …
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THE ROLE OF HYPOGLYCEMIC AGENTS IN AMELIORATING COGNITIVE FUNCTIONS AND PSYCHIATRIC SYMPTOMS: FROM THE PSYCHIATRIC PATIENT TO EVIDENCE-BASED AND PHARMACOEPIDEMIOLOGIC APPROACHES FOR SUPPORTING THE CLINICAL PRACTICE
… PPR(p)= 1.07 (0.00), EBGM95=0.96 ERAM95=0.89 in FAERS and ROR95=1.48 PPR(p)= 1.34 (0.00) EBGM95=1.22 and ERAM95=0.86 in VigiBase]. GLP-1a and DPP-4 inhibitors (DPP-4i) resulted in better outcomes with a preference for GLP-1a for reducing the risk of major cognitive impairment (dementia) in old …
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Optimization of Signal-Detection Methods in Novel Databases: a Focus on Direct-Acting Antivirals
… (FDA) Adverse Event Reporting System (FAERS) is a database containing ADE reports that were submitted to the FDA. The reports need to be investigated, and when working with large databases, signal detection algorithms (SDA) are used to decide which reports are significant. Signal …
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Predicting unknown adverse drug reactions using an unsupervised node embedding algorithm
… in the knowledge graph. Using DrugBank and FAERS, I created a knowledge graph of drugs and drug attributes. To emulate drugs in the pre-marketing stage, I removed all the drug-ADR edges in the test dataset. Then, I experimented with different parameters of the node embedding algorithm and …
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An Expandable Stage-Based Machine Learning and Statistical Pipeline for Detecting Adverse Drug Reaction Risks on Complex Multidimensional Datasets
Adverse Drug Reactions (ADRs) are a persistent challenge to patient safety, often escaping detection in aggregate analyses. This research introduces expandable, modular pipeline that identifies statistically significant drug–ADR associations through a multivariable, propensity-adjusted framework …