Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"FADS2"”.
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FADS2 expression modulates effect of dietary polyunsaturated fatty acids on western diet-induced glucose intolerance
Fatty Acid Desaturase 2 (FADS2) haplotypes associated with hyperactivity of its gene product, delta-6-desaturase (D6D), are associated with obesity and type-2 diabetes in humans. D6D regulates long-chain polyunsaturated fatty acid (PUFA) biosynthesis and is upregulated in several rodent models of …
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Investigating the Relation Between Genetic Variation in FADS1 & FADS2 with the LCPUFA Content of Extracellular Vesicles from Human Milk
… gene cluster that encodes the enzymes FADS1 and FADS2 may impact the concentrations of long-chain polyunsaturated fatty acids (LCPUFA) in human milk EVs. As integral components of the lipid membrane, the specific composition or balance of LCPUFAs may impact the bioavailability of EVs in newborns …
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THE ROLE OF BOTANICAL OILS ENRICHED IN FADS2-DERIVED N-3 VS. N-6 POLYUNSATURATED FATTY ACIDS IN PREVENTION OF ATHEROSCLEROSIS
… the rate-limiting fatty acid desaturase-2 (FADS2, delta-6 desaturase) step of fatty acid desaturation and elongation results in 18 and ≥ 20 carbon PUFAs that are substrates for pro-inflammatory and anti-inflammatory eicosanoid production, which affect atherosclerosis progression and …
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Regulation of n-3 PUFA biosynthesis in proliferating and differentiated PC12 pheochromocytoma cells
… involved in the FA metabolism; ElovJ5, EJovJ2, Fads2 and Ppara genes encoding, respectively, for ELOVL5 elongase, ELOVL2 elongase, Delta6 desaturase (D6D) and the nuclear transcription factor PPARa. LA up-regulates the expression of the above genes, whereas ALA specifically up-regUlates the mRNA …
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Evidence for the role of delta-6-desaturase in the development of cardiometabolic disease
… and 2) Determine whether over-expression of fads2, the gene that encodes for D6D, results in altered membrane fatty acid composition and the development of metabolic insults associated with (T2D). Studies in aim 1 demonstrated that the changes in fatty acid membrane composition observed in …
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Effects of dietary alpha linolenic acid on biosynthesis of N-3 long chain polyunsaturated fatty acids in animals.
… ALA diets, mRNA abundance of the Δ6 desaturase (FADS2) and elongase 2 (ELOVL2) genes were increased only in animals fed the low PUFA reference diet compared to those fed diets with adequate to high PUFA levels. There was no correlation between the gene expression of desaturases, elongases or …
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Key Genotypes and the Response to Nutrient Supplementation in Crohn’s Disease
… omega-three and-six fatty acid uptake (FADS1, FADS2); cholesterol (PPARA); cardiovascular risk and CD activity (PPARG); colorectal adenoma (XRCC1), and inflammation (SCD). Project Two To investigate, through a double blinded, randomized, placebo, crossover, 12 week trial, the response of 30 …
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Depletion of docosahexaenoic acid (DHA) and arachidonic acid causes male infertility by disrupting both secretory granule biogenesis and adherens junction assembly in testis
… to ARA and DHA, the fatty acid desaturase2 (Fads2) knockout mouse model allows for the creation of a HUFA-selective deficiency. Use of this Fads2 -/- model led to the discovery of HUFA essentiality in male fertility and supporting the proper maturation of germ cells within the testis. Here, …
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Biomarkers of fat intake
… to identify what appeared to be a FADS1/FADS2 haplotype predicting lower levels of LC-PUFA, which might be of public health significance.<br/>In conclusion, plasma fatty acid composition can be recommended to elucidate the potential relationships between polyunsaturated, trans-unsaturated …
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Positionsklonierung des Morbus Best-Gens VMD2
… einer Familie von Fettsäuredesaturasen (FADS1, FADS2 und FADS3), während ein anderes Gen ('Rabin3 interacting protein-like 1'; RAB3IL1) signifikante Sequenzidentität zu einem Transkript der Ratte besitzt, welches das GTPase-interagierende Protein Rabin3 kodiert. Den putativen …
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Effects of close-up dietary energy strategy and prepartal dietary monensin on hepatic mRNA expression of enzymes involved in glucose and lipid metabolism in transition cows
… ATP5G1), lipid metabolism genes (APOA1, APOB, FADS2, SCD, HMGCR), inflammation, acute phase response, and detoxification/oxidative stress genes (TNF, IL6, HP, GSTM1), growth hormone/IGF-1 axis genes (GHR, IGF1) and transcription factors (FOXA2, HNF4A, NR4A1, SREBPF2). In cows fed the CON diet, …
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The role of dietary arachidonic acid and docosahexaenoic acid in preventing the phenotype observed with highly unsaturated fatty acid deficiency
… expression in D6D-/- liver and homology to the Fads2 gene that encodes for D6D. Cloning and transfection of Fads3 into cultured HEK293 cells confirmed lack of D6D activity (Chapter 3). The order of appearance of D6D-/- phenotype due to HUFA deficiency had yet to be determined. A D6D-/- time …