Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 164 for “"FAD"”.
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La place occupée par la FAD chez les officiers recrutés depuis moins de dix ans
… vise à mieux comprendre la place qu’occupe la FAD dans la formation universitaire des officiers recrutés depuis moins de dix ans. Pour répondre à cette question de recherche, on s’appuie principalement au cadre de référence élaboré à partir des travaux de Lebaron sur l’enquête quantitative et à …
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Investigation of FAD Chemical Models to Study the Monoamine Oxidase Catalyzed Oxidation of Cyclic Tertiary-Allylamines
Flavin adenine dinucleotide (FAD) is a coenzyme that participates in the redox process of flavoenzymes. Attempts to characterize the catalytic pathways of these enzymes have relied in part on the use of FAD chemical models. The efforts described in this dissertation focus on the chemical model …
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Targeted depletion of RibF, a putative bifunctional FAD synthetase/ flavokinase in Mycobacterium smegmatis using CRISPR interference
… (FMN) and flavin adenine dinucleotide (FAD), it was hypothesized that silencing ribF would disrupt the biosynthesis of all flavoproteins, crippling numerous (essential) processes within the organism. Moreover, based on previous observations in Bacillus subtilis, it was predicted that the …
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Identification and Characterization of the Enzymes Involved in Biosynthesis of FAD and Tetrahydromethanopterin in Methanocaldococcus jannaschii
… pathways, such as biotin, coenzyme A, thiamine, FAD, PLP, etc.; methanogens need six additional coenzymes that are involved in the methane production pathway: methanofuran, tetrahydromethanopterin, coenzyme F₄₂₀, coenzyme M, coenzyme B, and coenzyme F₄₃₀. Although now it is known that some …
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Activités pilotes pour un programme d'enseignement de l'anglais L2 en FAD en France pour de futurs ingénieurs
… des activités d’apprentissage de l’anglais L2 en FAD, qui seraient plus efficaces, plus motivantes et plus rentables que l’enseignement en classe. Pour ce faire, on a expérimenté un concept de pairage à distance entre francophones et anglophones, où les participants discutent via MSN Messenger. …
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TQM : fad or fixture? Implementing total quality management in health care setting through the development and use of customer-supplier models
This research study reviews the global advances made in health care quality assurance, tracing its origins from the manufacturing and service industries through to the context of the health care industry. The Total Quality Management (TQM) model, originally adopted by the industrial sector is …
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Studies on the Flavin Binding Properties of Native and Protease-Activated Pyruvate Oxidase From Escherichia Coli
… dissociates into apoenzyme monomers and free FAD when treated with acid ammonium sulfate in the presence of high concentrations of potassium bromide. Reconstitution of the native enzymatically-active protein can be accomplished by incubating equimolar concentrations of apomonomers and FAD at …
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Familial Alzheimer's Disease Mutations in Presenilins Disrupt Endoplasmic Reticulum Calcium Leak
… proteins (APP), which are linked to familial AD (FAD). Presenilins are known to function as the catalytic subunit of the (-secretase complex and FAD mutations in presenilins affect APP processing, leading to the accumulation of Aᴲ peptide and amyloid plaque formation in AD brains. In addition to …
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Characterisation of the flavin adenine dinucleotide binding region in Myxococcus xanthus protoporphyrinogen oxidase
… in the presence of flavin adenine dinucleotide (FAD) and oxygen. FAD is a cofactor, functioning as an intermediate electron acceptor in the catalytic function of PPOX. In this study the FAD binding region in Myxococcus xanthus PPOX was analysed by engineering and characterising a selection of …
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Binding Affinity of Flavins to the Dehydrogenase Domain of SpNOX
… linker. The DH domain contains binding sites for FAD and NADPH/NADH that both participate in the electron transfer necessary for producing superoxide. Structural information of NOX’s is still relatively new to the scientific community. A recent structure of CsNOX (<em>cyanobacterial</em> NOX) …
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Tratamento de soluções de cromo (III) por flotação a ar dissolvido
… do processo de flotação a ar dissolvido (FAD) no tratamento de efluentes contendo cromo. Tal processo é analisado comparativamente à sedimentação. Urna revisão dos diferentes tipos de processos de separação ou de recuperação do cromo é, também, aqui apresentada. Soluções contendo 200 mg.l" …
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Biochemical Studies of the Sodium -Translocating NADH:ubiquinone Oxidoreductase
… predicted to be essential to the binding of the FAD cofactor. By mutagenesis and spectroscopic characterization, the four conserved cysteines are confirmed to be the ligands for the 2Fe-2S center, and R210, Y212, S245 are confirmed to be important for the binding of the FAD cofactor in Na +-NQR. …
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Structural and mutagenesis studies of soluble methane monooxygenase reductase from Methylococcus capsulatus (Bath)
… The structure consists of a two domains, an FAD binding domain with a six-stranded antiparallel β-barrel and one α-helix, and an NADH binding domain with a five-stranded parallel β-sheet surrounded by four α-helices. The FAD cofactor is bound at the interface between the two domains in a …
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The roles of redox active cofactors in catalysis : structural studies of iron sulfur cluster and flavin dependent enzymes
… Two cofactors, flavin adenine dinucleotide (FAD) and [4Fe-4S] clusters, were originally determined to aid in electron transfer and redox chemistry. However, additional activities for these cofactors continue to be discovered. The study of FAD in the context of rebeccamycin and staurosporine …
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Two versatile cofactors, flavin adenine dinucleotide and non-heme iron, involved in DNA repair and natural product halogenation
… cofactors, flavin adenine dinucleotide (FAD) and non-heme iron, together with molecular oxygen as an oxidizing agent, perform a wide array of reactions. Hydroxylation in DNA repair is one example. AidB is an adaptive response protein that is up-regulated in the presence of alkylating …
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Structural Dynamics and Signaling Roles of the Aer PAS and F1 Regions
… and it monitors internal energy (redox) via an FAD cofactor bound to a cytoplasmic N-terminal PAS domain. Understanding PAS sensing is important, as PAS domains comprise a superfamily of more than 25,000 members from all kingdoms. This study focused on the Aer N-terminal PAS sensor, as well as …
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Cytotoxic effects of electron carriers are inhibited by Hsp27 in breast cancer cell lines
… sensitivity only at the highest concentration. FAD, NADH, Q10 and ATP were incubated with cells at 1 x 10 -9M, 1 x 10-8M and 1 x 10 -7M. Incubation of FAD with DC4 and DB46 was also done at 5 x 10-7M, 5 x 10-6M and 5 x 10-5M. FAD, ATP and NADH were more effective in cell death induction at much …
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New Insights Regarding the Intracellular Effects, Trafficking, and Quality Control of the Amyloid Precursor Protein: Implications for Alzheimer’s Disease Pathogenesis
… the disease, collectively known as familial AD (FAD). FAD is associated with discrete mutations in three genes: PSEN1 and PSEN2, which encode the presenilin proteins, and APP, which encodes the amyloid precursor protein (APP). Several hypotheses exist for the pathogenesis of AD. According to the …
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Modeling Alzheimer's Disease in Induced Pluripotent Stem Cells
… tau spreading and Aβ production in familial AD (FAD) PSEN1 mutants. Using TALENs, we generated a transgenic donor iPSC line that harbors a transgene for inducing the expression of fluorescently tagged tau protein and a recipient iPSC line that expresses membrane anchored YFP. These cell lines, …
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