Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"FABP4"”.
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Molecular Determinants of Residual Disease In Ovarian Cancer
… databases and microarray datasets, we identify FABP4 and ADH1B as markers of residual disease since the high expression of these genes in tumor samples is directly associated with the incidence of residual disease. We then investigate the underlying biology of residual disease and further …
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Uncoupling Lipid Metabolism from Inflammation in Adipose Tissue
… deficiency of fatty acid binding protein 4 (FABP4, also know as aP2) in macrophages suppresses inflammatory activation of the cells and contributes to whole body insulin sensitivity in an animal model. However, the mechanism of how FABP4 deficiency leads to the suppressed inflammatory was not …
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Identification of Anti-inflammatory and Antioxidant Properties of MangostinXanthones in Adipocyte Reporter Assays
… fatty acid binding protein 4 promoter (<i>Fabp4</i>-P)/CFP, and nuclear factor erythroid 2-related factor2 promoter (<i>Nrf2</i>-P)/YFP fluorescent reporters. We hypothesized that fluorescent signals directly correlated to inflammatory, adipogenic, and antioxidant status in adipocytes, …
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Associations between gene variations and milk composition in New Zealand dairy cattle: A thesis submitted in fulfilment of the requirements for the Degree of Doctor of Philosophy at Lincoln University
… (DGAT1), the fatty acid binding protein 4 gene (FABP4), the stearoyl-CoA desaturase (Δ-9-desaturase) gene (SCD1), the perilipin-2 gene (PLIN2) and the lipin-1 gene (LPIN1). These genes were chosen because they had either been implicated in fatty acid (FA) metabolism in mammary gland cells, or …
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Gene variations of FABP4, SCD, GH, and IGF1R and their associations with meat and carcass traits in sheep : A thesis submitted in fulfilment of the requirements for the Degree of Doctor of Philosophy at Lincoln University
… of the genes for fatty acid binding protein 4 (FABP4), stearoyl CoA desaturase (SCD), growth hormone (GH) and insulin-like growth factor 1 receptor (IGF1R) with meat characteristics such as intramuscular fat (IMF) levels, fat percentage, fatty acid profile, and carcass traits. This understanding …
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Mechanisms Underlying Distinct Egfr Versus Fgfr-3 and -1 Dependency In Human Bladder Cancer Cells
… biological phenotypes controlled by PPARγ-FABP4 pathway. This study significantly extends and complements our knowledge of molecular mechanism that mediates growth receptor dependent proliferation in BC.</p>
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Influence of body weight gain on insulin regulation, adipose tissue inflammation and lipid metabolism in equines
… IL-6, TNFα) and markers of lipid metabolism (FABP4, LPL) were analyzed in AT samples by RT-qPCR. The project was approved by the Ethics Committee for Animal Rights Protection of the Leipzig District Government (No. TVV 32/15). Data were analysed for normal distribution by Shapiro-Wilks test. …
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Effects of dietary macronutrient composition and exogenous neuropeptide Y on adipose tissue development in broiler chicks
… of mRNAs encoding fatty acid binding protein 4 (FABP4) and monoglyceride lipase in chicks fed the HC and HF diets than the HP diet in all three adipose tissue depots. Fasting increased plasma non-esterified fatty acid concentrations in chicks fed the HC and HP diets. Results suggest that the …
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Cellular and Molecular Mechanisms Governing Intramuscular Fat Development and Growth in Cattle
… several genes downregulated in IMF, such as FABP4, AGPAT2, and PLIN2, were key promoters of adipocyte differentiation. Functional enrichment analysis revealed that genes downregulated in IMF were enriched in the PPAR signaling pathway and adipogenesis-related processes, whereas genes …
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Design and synthesis of novel compounds as fatty acids binding protein inhibitors and as gallium-68 chelators for positron emission tomography
Finding new small molecules targets as well as improving the diagnosis methodologies are two of the most important areas in which the researchers are spending efforts to improve our arsenal to fight cancer and other diseases. In this thesis, two different chapters are discussed. In the first one, …
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Exploring the effect of peri-operative inflammation on systemic and local breast cancer biomarkers
… tumour tissue samples, IL6, Leptin, JAK1, CD38, FABP4 and Adiponectin gene expression were significantly higher in NAT compared to matched tumour samples. Pre-operatively the mean cfDNA concentration was 3.82ng/μL (SEM = 0.74). This increased significantly early post-op in keeping with surgical …
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Design and synthesis of small molecules for oncological and neurodegenerative diseases with multitarget properties [Progettazione e sintesi di piccole molecole con proprietà multitarget per malattie oncologiche e neurodegenerative]
Questa ricerca di dottorato affronta l’esigenza urgente di strategie terapeutiche innovative contro malattie complesse come il cancro e i disturbi neurodegenerativi, in cui i farmaci a singolo bersaglio spesso falliscono a causa della patogenesi multifattoriale e della resistenza ai farmaci. Il …