Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"FAB Fragment"”.
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Vergleich eines rekombinanten Anti-ICAM-1-Fab-Fragmentes mit einem IgG-Vollantikörper in der Behandlung von Verbrennungstraumata am Kaninchen
… was to test the efficiency of an anti ICAM-1 fab fragment compared to an IgG full antibody in the treatment of burn injury in rabbits. Former studies in animal as well as in human trials confirmed the positive effect of a murine IgG antibody against the enlargement and the conversion of the …
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Generierung von Antikörper-Bibliotheken und Selektion von Antikörpern gegen die Integrine αvβ5 und α5β1 mittels Phagen-Display-Technologie
… auf. Antiangiogenese in Form von Antikörper-Fragmenten, welche Integrine als Zielstruktur haben, ist daher in der Therapie von Tumoren ein wichtiger und viel versprechender Ansatzpunkt.In dieser Dissertation wurden erstmals chimäre humane/Kaninchen-Fab-Fragment-Bibliotheken gegen die …
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Development of polymeric nanoparticulate formulation encapsulating protein molecules following hydrophobic ion pairing complexation
… chosen two model antibody proteins: Human IgG-Fab fragment and Human IgG, and prepared their HIP complexes. Different ion pairing agents and HIP complexation parameters were optimized. Consequently, optimized HIP complexes were loaded in polymeric nanoparticles. As a result, significant …
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Genetic engineering of antibody fragments for the detection of illicit drugs
… on the development of a repertoire of antibody fragments against various illicit drugs including morphine-3-glucuronide (M3G), amphetamine and tetrahydrocannabinol (THC). Antibody libraries were generated from murine, avian and leporine immune systems. A number of antibody fragments were …
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Novel anitbody-based assays for disease and food contaminant detection
… isolated Am1-specific single chain variable fragment (scFv) was converted to a chimeric Fab format by the addition of human constant regions, using PCR assembly methods. A mutant Fab fragment was also isolated and demonstrated improved assay performance when compared to the parent scFv. The …
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Biofunctionalization of Submicrometer Pores and Mass Limited Sample Manipulations in Three-Dimensional Hybrid Microfluidic/nanofluidic Devices
… recognition is realized by immobilizing the Fab' (fragment of atigen binding) of antibody on the inner walls of the NCAM. Selective capture and release of the specific analyte using the Fab' modified NCAM are demonstrated offline using scanning electron microscopy and matrix-assisted laser …
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In vitro models of cartilage degradation following joint injury : mechanical overload, inflammatory cytokines and therapeutic approaches
… was partly reduced by an IL-6 blocking Fab fragment. Interestingly, cartilage degradation induced by the combinations of proinflammatory cytokines and mechanical injury was fully abrogated by short-term treatments with dexamethasone. The results of this work are significant in that they …
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Peptide/Protein Stapling and Unstapling: Introduction and Photorelease of Isobutylene Graft
… interchain disulfides of antibodies by avoiding Fab exchange and disulfide shuffling. This general method was applied to an anti-HER2 Fab fragment and full-length IgGs under mild and biocompatible conditions. The binding affinity of the antibody was enhanced, relative to its native form, after …
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Development of Random Triblock Copolymer Based Nanoparticulate Formulation for Sustained Release of Macromolecules/Biologics in Treatment of Posterior Segment Ocular Diseases
… include catalase, IgG, bovine serum albumin, IgG Fab fragment, lysozyme, insulin and octreotide. Our results observed the effect of macromolecule molecular weight on drug loading and entrapment efficiency. In order to ensure sustained and prolonged release, nanoparticles were suspended in …
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The Tetraspanin CD9 Localizes to Platelet-Platelet Contacts and Regulates Thrombus Stability
… CD9 contributions to platelet function, a Fab fragment was generated from mAb7, an antibody which binds with high affinity to the large extracellular loop of CD9. Fab fragments were used to avoid complications of bound antibody crosslinking CD9 with the platelet FcγRII receptor. Confocal …
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Transport of proteins, biopharmaceuticals and small pharmaceutical compounds into normal and injured cartilage by Sangwon Byun.
… TNFa, on the uptake of anti-IL-6 antibody Fab fragment (48 kDa). Anti-IL-6 Fab was able to penetrate into cartilage, though final equilibrium uptake would likely occur only after 6-10 days within 1 mm thick explant disks. Uptake of anti-IL-6 Fab was significantly increased following …