Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"FAAH"”.
-
Investigating Endocannabinoid Metabolism in Alcohol Use Disorder: a focus on fatty acid amide hydrolase (FAAH)
… enzyme, fatty acid amide hydrolase (FAAH), has been proposed as a therapeutic target for Alcohol Use Disorder (AUD) and psychiatric illnesses. Studies suggest that FAAH regulates alcohol intake/preference, and its impairment increases risk for alcohol use disorder (AUD). This thesis’ …
-
Ghrelin, Cannabinoids, and Motivation: Increased Food Motivation on Progressive Ratio Paradigm Through MAGL/FAAH Inhibition in a Rat Model
… infusion of cannabinoid degrading enzymes (MAGL/FAAH) inhibitors (MJN110/PF-00457845), followed by ghrelin. Next, we examined the protein level of cannabinoid related enzymes in the VTA following an injection of ghrelin using western blotting. Our results show a significant increase in motivated …
-
A COMPARISION OF DELTA-9-TETRAHYDROCANNABINOL DEPENDENCE IN C57Bl/6j MICE AND FATTY ACID AMIDE HYDROLASE KNOCK OUT MICE
… using mice lacking fatty acid amide hydrolase (FAAH), the enzyme responsible for anandamide metabolism, would ameliorate THC dependence. Mice were treated subchronically with a low or high THC dosing regimen and challenged with the CB1 receptor antagonist, rimonabant, to precipitate withdrawal. …
-
N-Acylethanolamine Metabolism During Seed Germination: Molecular Identification of a Functional N-Acylethanolamine Amidohydrolase
… enzyme designated fatty acid amide hydrolase (FAAH). Based on the characteristic amidase signature sequence in mammalian FAAH, a candidate Arabidopsis cDNA was identified and isolated by reverse transcriptase-PCR. The Arabidopsis cDNA was expressed in E. coli and the recombinant protein indeed …
-
Targeting the Endocannabinoid System to Reduce Inflammatory Pain
… rapid hydrolysis by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively. Selective inhibition of either enzyme elevates CNS levels of the appropriate endocannabinoid and produces analgesic effects with fewer psychomimetic side effects than Δ9-tetrahydrocannabinol …
-
Investigation of chemotherapy-induced peripheral neuropathy-related behaviour in male and female ratsa role for the endocannabinoid system
… (1) inhibition of fatty acid amide hydrolase (FAAH), (2) antagonism of the transient receptor potential vanilloid 1 (TRPV1) channel, and (3) dual FAAH inhibition/TRPV1 antagonism. All treatments, administered systemically, significantly reduced PTX-induced mechanical hypersensitivity, while the …
-
Das endogene Cannabinoid Anandamid erhöht Cyclooxygenase-2-abhängig den pulmonalarteriellen Druck in der isolierten Kaninchenlunge
… Das physiologische Vorkommen der Enzyme FAAH und COX-2 in der Kaninchenlunge wurde mittels RT-PCR nachgewiesen. Der Thromboxan-Rezeptorantagonist SQ 29,548 hatte keinerlei Effekt auf die Anandamidwirkung. Jedoch konnte der spezifische EP1-Rezeptorantagonist SC 19220 den Effekt von …
-
Endocannabinoid and lipid metabolism genes network analysis in adipose and liver tissue of dairy cows during the transition period
… enzymes that degrade endocannabinoids (FAAH, NAAA, MGLL), and the hormone precursor proopiomelanocortin (POMC). We also examined mRNA expression via qPCR of genes associated with lipolysis (LIPE, ABDH5, ATGL), fatty acid oxidation (CPT1A, CPT2, ACADVL, ACOX1), oxidative stress (SOD1, …
-
Transition cows: hepatic endocannabinoid system gene expression in response to prepartal plane of nutrition and the effects of genetic merit on genes of lipid metabolism in adipose tissue
… (HRASLS5, NAPEPLD), enzymes that degrade FAE (FAAH, NAAA, MGLL), and the hormone precursor proopiomelanocortin (POMC) in liver at -14, 7, 14, and 30 d around parturition from cows fed a control (CON; NEL = 1.34 Mcal/kg) or moderate-energy (OVER; NEL = 1.62 Mcal/kg) diet during the dry period. …
-
Bioactive Lipids in Nociception
… is presented for a fatty acid amide hydrolase (FAAH)-dependent fatty acid conjugation of p-aminophenol, a known acetaminophen metabolite, to form the potent TRPV1 activator AM404 in the central nervous system. We show that acetaminophen is able to reduce the content of prostanoids in brain and …
-
Cannabinoid Modulation of Reinforcement Maintained by Stimulation of the Medial Forebrain Bundle in C57Bl/6J Mice
… THC, as well as the fatty acid amide hydrolase (FAAH) inhibitor, PF-3845, the monoacylglycerol lipase (MAGL) inhibitor JZL184, and the combined FAAH/MAGL inhibitor SA-57 in ICSS of the medial forebrain bundle in C57BL/6 mice. Additionally, we assessed the psychomotor stimulant cocaine as a …
-
Design, synthesis and SAR of small molecules acting on pain pathways
… were designed and tested as inhibitors of FAAH, the principal enzyme involved on the metabolization of endocannabinoids. The aim was to cause an increase of the endocannabinoids concentration which leads to analgesic effect by the potentiation of the endocannabinoid tone. Some of the …
-
Endocannabinoid Modulation of Spatial Memory in Aversively and Appetitively Motivated Barnes Maze Tasks
… signaling, via genetic deletion of the FAAH enzyme, accelerated acquisition of the task under aversive, but not appetitive, conditioning procedures. Accordingly, these data strongly support the hypothesis that the endogenous cannabinoid system plays a necessary role in the extinction of …
-
The bioactive role of omega-3 endocannabinoid epoxide regioisomers
… hydrolase (sEH) and fatty acid amide hydrolase (FAAH) inhibitors. Furthermore, we showed that two specific regioisomers 8,9-EEQ-EA and 13,14-EDP-EA, dose dependently reduced nitrite production and reduced levels of interleukin-6 (IL-6) in LPS stimulated BV-2 microglial cells. Lastly, we …
-
The Role of MAGL Inhibition in Nicotine Withdrawal and Reward
… of low-dose JZL184 and high dose of the FAAH inhibitor PF-3845 on spontaneous nicotine withdrawal. Indeed, the combination of low-dose JZL184 and PF-3845 significantly attenuated nicotine spontaneous withdrawal signs. MAGL inhibition by JZL184 dose-dependently caused a significant …
-
The Genetics of Differential Fat Distribution: The Insulin Resistance Atherosclerosis Family Study
… and IQGAP1) and VAT (FETUB, PTPRD, STAT3, and FAAH) genes were identified. In the analysis of 99 SNPs within these candidate genes in the AA of the Diabetes Heart Study (DHS), MYO18B was the only gene that illustrated evidence of association for obesity measures with the original exonic SNP …
-
On the Analysis of Mouse Behavior
… version of the Fatty Acid Amide Hydrolase (FAAH) enzyme that is associated with addiction, in male and female mice. Knock-in animals displayed reduced activity in response to increasing instrumental effort, and reduced activity on the first day of an extinction test. Then, to encourage …
-
Estudios de efectos neurobiológicos del Δ9-tetrahidrocannabinol (THC) en modelos animales
… regula al alza la expresión génica de la enzima FAAH en corteza prefrontal y estriado dorsal. 14) Se observaron centros germinativos aparentemente “quiescentes” en diversas zonas en ratas prepúberes: núcleo arcuato del hipotálamo, órgano subcomisural alrededor de la zona dorsal del tercer …