Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 32 for “"F4/80"”.
-
EGF module-containing mucin-like hormone receptor 2 and its role in human immune privilege
… G protein-coupled receptor (ad-GPCR) molecule, F4/80, is required for the development of regulatory T cells in two models of tolerance, the eye and gut. Since F4/80 is not expressed in humans, the purpose of this research is to determine the human analog of F4/80. F4/80 belongs to a novel family …
-
Targeting and Reprogramming Tumor-Associated Macrophages with Polymeric Nanoparticle-Mediated mRNA Delivery for Cancer Treatment
… polymeric nanoparticle (PNP), named CAR-APP-F4/80, with small size, low toxicity and strong targeting for efficient CAR-mRNA delivery to TAMs. Its excellent mRNA encapsulation efficiency and successful cell uptake and endosome escape in RAW264.7 were proved. CAR-APP-F4/80 showed strong …
-
Die Rolle des Interleukin-6 bei der Wallerschen Degeneration
… immunhistochemisch die Makrophagen-Antigene F4/80, Mac-1, LFA-1 und es wurden Semidünnschnitte angefertigt um die Makrophagen-Phagozytose-Aktivität und die Myelindichte zu beurteilen.
-
Intestinal macrophages in health and inflammation
… of the myeloid cells expressing the F4/80 mφ marker in the colon of normal mice are described in Chapter 3. These revealed that the F4/80+ population in the gut is extremely heterogeneous compared with other mφ populations in the body. Virtually all in vitro-differentiated BM mφ (BMM) …
-
The role of caspase-1 in liver and adipose tissue during metabolic dysregulation in mouse models on NASH
… in inflammatory markers, such as TNF¿¿ and F4/80, and increases in HSC activation marker, ¿¿SMA and the deposition of collagen-1. These effects were independent of ALT levels, apoptosis and caspase-3 expression. Deletion of macrophages in the liver by clodronate liposomes suppressed …
-
Role of Splenic B Cells and Gamma Delta T Cells in the Induction of Peripheral Tolerance Elicited Through the Anterior Chamber of the Eye
… of complex cellular interactions that involve F4/80+ ocular antigen presenting cells (APC), NK T cells, B cells, gamma delta (gamma delta ) T cells, CD4+CD25+ Tregs, and CD8+ Tregs. Antigens injected into the AC are processed by F4/80+ antigen presenting cells (APC), which migrate to the thymus …
-
Die Rolle von Interleukin-6 beim Myelinabbau durch Makrophagen
… exprimieren alle die Oberflächenproteine F4/80, CD11b, CD204 und CD16/32, anhand derer sie sich im Gewebe nachweisen lassen. Anschließend durchgeführte immunhistologische Untersuchungen des N. ischiadicus ermöglichten die Beurteilung der Makrophagenaktivität. Die Makrophagenaktivität lässt …
-
Tumor Angiogenesis is all Tied up in Tie2-Expressing Macrophages
… the TEM population while the total number of F4/80+ macrophages did not change between M-CSF and vehicle control treatment groups. In this model, M-CSF administration enhanced tumor angiogenesis, while having no significant effect on tumor size. No metastatic effects were examined. Given the …
-
PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy
… to p85ƒÑ or p110ƒÑ, as reflected by a paucity of F4/80+ cells present by immunohistochemistry (IHC). Additionally, PI3K inhibition led to an aberrant hepatocyte architecture characterized by vacuolization, lipid deposition, and glycogen accumulation. My data demonstrate that PI3K/Akt pathway …
-
Characterization of Immune Cell Populations in White Adipose Tissue of Wild Type and Bovine Growth Hormone Transgenic Mice
… the global leuckocyte cell population, and CD36-F4/80 positive immune cells, which represent M2 macrophages, were significantly increased in bGH subcutaneous and mesenteric depots compared to controls. In conclusion, the significant decrease in adiposity caused by excess GH leads to marked …
-
JAG1 Blockade With oHSV Polarizes Macrophages to Create a Unique Vulnerability for Cetuximab-Mediated Senolysis of Glioma Cells
… RNA sequencing and flow cytometric analysis of F4/80+ cells isolated from infected tumors showed a shift from tumor-supporting TAMs to inflammatory macrophages upon OncoD-0J1 treatment. Senescent cells showed heightened EGFR activation as a mechanism to escape death, which created a unique …
-
Group IV Cytosolic Phospholipase A2α Is Critical for the Development of Angiotensin II-Induced Hypertension and Associated Pathogenesis
… also increased cardiac and renal infiltration of F4/80+ macrophages and CD3+ T lymphocytes, caused cardiac fibrosis and produced cardiovascular and renal oxidative stress and end organ damage, in cPLA2α+/+ but not cPLA2α-/- mice. Infusion of Ang II increased cardiac ER stress and activity of …
-
HEPATOCYTES COORDINATE A SYSTEMIC ENDOCRINE NETWORK IN CANCER
… by an accumulation of Ly6G+ granulocytes and F4/80+ macrophages, increased deposition of fibronectin, and upregulation of the IL-6/JAK/STAT3 pathway. Subsequent transcriptomic analysis of STAT3 deficient livers identified hepatocyte-derived acute phase reactants serum amyloid A proteins 1 & 2 …
-
Modulation of the tumor microenvironment by the CXCR4 antagonist AMD3100 in pancreatic and colorectal adenocarcinoma
… phase are presented. A dose-rate of AMD3100 80ug/kg/hr was safe, reasonably well tolerated, and achieved relevant plasma concentrations at steady state. However, pharmacodynamic makers of CXCR4 inhibition, including peripheral white blood cell and CD34+ cell mobilization, were maximal at the …
-
Abscisic acid ameliorates glucose tolerance and obesity-induced inflammation
… surface glycoprotein and maturation marker F4/80 (F4/80hi vs F4/80lo). Dietary ABA-supplementation significantly reduced F4/80hiCCR2+ ATMs and had no effect on the F4/80lo population. Utilizing a tissue-specific knockout generated through Cre-lox recombination, we were able to determine that …
-
Role of Properdin in Tumour Growth and Cell Recruitment
… regulatory T cells, M2<br/>macrophages (CD206+F4/80+) and TGF-β were decreased significantly in<br/>properdin deficient compared with wildtype mice (control) after subcutaneous<br/>injection with B16F10 cells, indicating that properdin may contribute to the<br/>accumulation of MDSCs in spleen, …
-
In Vivo Studies on the Transcriptional and Posttranslational Regulation of the CCAAT/Enhancer Binding Protein Beta
… population, showed that the cells are Mac1(+), F4/80(+) and Gr1(+), typical markers of Natural Suppressor macrophages. Taken together, the C/EBPbeta target genes found in the macrophage and the cell surface markers, suggest an immunosuppressive phenotype. we propose a novel role for C/EBPbeta in …
-
Role of Macrophages in Ocular Surface Fibrosis
… and flow cytometry for macrophage markers CD11b, F4/80, CD86, CD206, iNOS, and arginase-1. Our data demonstrates that irradiation caused an increase in macrophage pro-inflammatory cytokines IL-1b, TNF-a, and IL-6 and chemokine CCL2. While irradiation did not cause increase in M1 markers, there was …
-
Immunotherapeutic Strategies to Reverse Tumor Associated Immunosuppression in Breast Cancer
… of all four MDSC maturation markers, CD80, CD86, MHCII and F4/80. Additionally, Pam also significantly reduced the number of MDSCs in the treated whole splenocyte cultures.</p> <p>Future studies that are discussed here will expand our knowledge on the effect of tumor derived G-CSF in …
-
Follow your gut: Does AKR1D1 impact gastrointestinal health?
… female mice, as was the pan-macrophage marker, F4/80, at mRNA and protein level. Suggestive of impaired barrier function, intestinal morphology of the AKR1D1 KO mice was modified, key ileal and colonic tight junction mRNA and protein levels were altered, goblet cell number and mRNA levels of key …
Page 1 of 2