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Showing 1 to 20 of 79 for “"F100 - Chemistry"”.
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An Investigation of the Genetic Control of Biofilm Formation in Bacteria (E. coli K-12 MG1655)
The ability to adapt to changing environments is essential for survival. Bacteria have developed sophisticated means by which they sense and respond to stresses imposed by changes in the environment. Escherichia coli (E. coli) have served as a model organism for studies in molecular genetics and …
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Proniosome formulations for pulmonary drug delivery
In this study niosomes were generated from proniosomes (Span 60: Cholesterol 1:1) using beclomethasone dipropionate (BDP, 5 mole %) as a model drug. When niosomes were processed via probe sonication, photon correlation spectroscopy study showed that niosomes generated from proniosomes had larger …
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Development of an Intelligent Robotic Manipulator
The presence of hazards to human health in chemical process plant and nuclear waste stores leads to the use of robots and more specifically manipulators in unmanned spaces. Rapid and accurate performance of robotic arm movement and positioning, coupled with a reliable manipulator gripping mechanism …
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The interactions of Propafenone and its enantiomers with the major human forms of cytochrome P450 in terms of inhibition and metabolic rates
Propafenone is a class 1C antiarrhythmic drug used for the treatment of ventricular arrhythmias. Propafenone is a chiral compound which is normally administered as the racemate. The use of racemate therapy can be problematic as variability in both the pharmacodynamic and pharmacokinetic properties …
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An Investigation of The Use of Dendrimer-Based Carrier to Cross Cellular Barrier
Dendrimers are a novel class of highly branched polymers with a high degree of uniformity and monodispersity. As a result of the unique properties and characteristics of dendrimers, they have found a wide range of pharmaceutical applications. This study investigated the ability of polyamidoamine …
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The separation of specific enantiomers of anticancer reagent cytarabine using HPLC.
During the research and development stage of any drug candidate, there is a growing need to investigate the properties of existing enantiomers, if the drug possesses chirality. It is becoming increasingly more of a requirement to separate specific enantiomers in order to optimize the potency and …
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Stemness status in differentiated and undifferentiated glioma cells
Undifferentiated cancer stem cells (CSCs) with their unique potential of self-renewal and multi-lineage differentiation fuel tumour growth and relapse. Efficacy of glioma therapy can be considerably improved if the target is focused towards successful identification and elimination of CSCs. The aim …
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Investigation of the Fire Behaviour of PEEK-based Polymers and Compounds
Polyetheretherketone (PEEK) is a polymer with outstanding performance, particularly concerning temperature resistance, chemical resistance and mechanical characteristics. Literature shows a gap in the knowledge with regards to PEEK flammability and decomposition products. The aim of this thesis is …
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Excited state intramolecular proton transfer (ESIPT) to nitrogen in heterocyclic compounds
… were prepared in order to study the photochemistry of these compounds when ESIPT is not possible. The absorption and fluorescence properties of these systems were studied as a function of solvent, temperature and pH conditions. Lifetimes, quantum yields and pKa data were determined under …
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The synthesis and ion-exchange chemistry of vanadium doped natisite and paranatisite
With 440 commercial nuclear reactors in use globally, nuclear energy contributes to 11 % of the world’s energy demands[1]. Like most forms of energy, nuclear energy generates waste. To help manage contaminated aqueous streams generated from the nuclear cycle, i.e., reactor primary coolant and the …
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New photosensitisers for photodynamic therapy
The Photodynamic Therapy (PDT) of cancer is a relatively new area of cancer research. It involves the use of tumour specific drugs that are non-toxic in the absence of light but, when irradiated, react either with oxygen to give the cytotoxic singlet oxygen or directly with biomolecules and so …
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The synthesis, characterisation and photochemistry of novel organometallic complexes
… metal can radically alter the ligand photochemistry. In order to investigate these effects, we synthesised a series of organometallic complexes with several different modes of ligand-metal bonding. The synthesis of various cyclopentadienyl, arene, diene and enone complexes was attempted. …
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Fluorescent sensors for metal ions
… in many fields including trace analysis in chemistry and biochemistry. Using the "dual fluorescence" properties of TICT state compounds (Twisted Intramolecular Charge Transfer which gives an extra red-shifted emission band) and the key property of crown ether compounds which is their ability …
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Trans coordinating bidentate ligands
A number of novel bidentate ligands have been designed, which would, because of steric constraints, coordinate exclusively across the trans positions in a square planar complex. Such complexes could show optical activity centred on the metal if the four ligand groups (A,B,C,IJ in the diagram) were …
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Thermally Responsive Peptide Coated Superparamagnetic Iron Oxide Nanoparticles for Drug Delivery
Target specific delivery of anticancer drugs to the effected site without showing systematic toxicity to normal tissues is important. Multifunctional biodegradable delivery systems reduce systematic toxicity in an efficient manner. These drug carriers should provide controlled release, be directed …
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A study of the effect of Si:Al Ratio and ion-exchange on the ability of the zeolite ZSM-5 to adsorb common analgesics from waste water
Due to the expansion of the pharmaceutical industry, the increase in demand and current inadequate removal methods, pharmaceutical waste has been increasing in concentration in environmental waters. It is unknown what the chronic effects this waste could have on humans and so more adequate removal …
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Alkyl, alkenyl and cycloalkyl substituted triphenylmethane dyes
A series of Malachite Green derivatives containing alkyl an alkenyl substituents in the 2-, 3-. and 4- positions has been synthesised. Their respective visible absorption spectra have been correlated with the electronic and steric effects of the methyl, ethyl, propyl, butyl and vinyl substituents …
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An investigation into the active sites in co-reactants for carbonless copying paper
… is a study of certain aspects of the surface chemistry of materials used as co-reactants in carbonless copying paper and of some materials which show promise for such a use. The areas investigated include the ion exchange characteristics of acid activated clays, the reactivity of a primary …
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Solvolysis of cobaltammines
The reactions studied were the aquaton of chloropentammine cobalt III chloride and the anation of aquopentanmine cobalt III ions with chloride ions in various e thanol—water rixtures. First order kinetics were observed for the aquation reaction being first order in cobalt concentration. The rate of …
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Palladium and platinum complexes of trans-coordinating bidentate phosphine ligands
Two ditertiary phosphine ligands, 1,6.-bis(diphenylphosphino)-hexane, (dPh), and 3,31_bis(diphenylphosphinomethyl)biphenyl, (PP), have been used in the preparation of complexes described in this work. Construction of molecular models proved useful in predicting the likely geometries of the …
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