Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"F-box protein"”.
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Functional Analysis of the F-box protein Fbxl17
… from primary breast tumours, we found that the F-box protein encoded by FBXL17 is frequently rearranged in breast cancer. F-box proteins are the substrate-recognition components of Skp1-cullin 1-F-box protein (SCF) E3 ligases. As essential components of the ubiquitin proteasome system (UPS) they …
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DRE-1/FBXO11, a Conserved F Box Protein, Regulates Apoptosis in C. elegans and is Mutated in Human Lymphoma
… both the CED-3 caspase and CED-4/Apaf-1 adaptor proteins, the BH3-only protein EGL-1 is dispensable. Thus, other gene(s) substitute for egl-1's role as a regulator of caspase activation in this cell, and we set out to identify the relevant gene or genes. A screen for mutants in which the …
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On Sulfur Sensing in Saccharomyces cerevisiae
… can be distilled down to the actions of two proteins; the F-box protein Met30, and the transcriptional coactivator Met4. Met30 belongs to the family of SCF (Skp1-Cul1-F-box protein) E3 ubiquitin ligases, and negatively regulates the transcriptional activity of the master transcriptional …
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ELUCIDATION OF REGULATORY MECHANISMS OF TRANSCRIPTION AND COUPLED mRNA EXPORT
… is driven by the combined actions of numerous proteins that act in a regulated fashion. One of the central processes in gene expression is the export of the synthesized mRNA from nucleus to the cytoplasm where it gets translated into proteins. This journey of mRNA is mediated by numerous …
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MECHANISMS OF SUBSTRATE DEGRADATION AND RECRUITMENT BY CULLIN E3 LIGASES
Protein degradation plays an important role in regulating many cellular processes. Ubiquitination, a prerequisite for protein degradation, is mediated by the Cullin E3 ubiquitin ligase family. The aim of this study is to achieve a better understanding of the function and regulation of Cullin E3 …
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Modulation of plant growth by day length dependent regulation of the TOR signaling pathway
… meristems. Downstream of TOR, the 40S ribosomal protein S6 Kinase 1 (S6K1) modulates both cell growth and proliferation. Since S6K1 accumulation is modulated by the circadian clock, this thesis investigated how changes in S6K1 levels would affect plant growth when the clock function is impaired …
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Characterization of the IBR5-PAD1 Interaction in Arabidopsis Auxin Response
… environmental stress. In this process the target proteins are polyubiquitinated by a multi-subunit E3 ubiquitin ligase complex, essentially tagging the target proteins for degradation by the 26S proteasome. One specific type of E3 ligase, the SKP1-CULLIN1-F-BOX protein (SCF) complex, is utilized …
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The Functional Synergy Between Yeast Dynamin and Key Membrane Recycling Factors
… GTPases are known to regulate the function of F-box protein Rcy1p, which mediates recycling of the plasma membrane v-SNARE Snc1p. Tlg1p and Tlg2p t-SNARE's are required for efficient endocytosis and mediate fusion of endosome derived vesicles with the late Golgi body. The dynamin-like GTPase …
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Understanding the protein complexes involved in the reception of the plant hormone Strigolactone
… by its receptor, DAD2, an α/β hydrolase fold protein. This receptor also functions as a slow enzyme that hydrolyses SL into two non-active by-products. The hydrolytic function of the receptor is essential for SL signalling and enables the receptor to interact with the downstream signalling …
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The genetics of the sexually dimorphic deaths of the C. elegans CEM neutrons
… survival I identified two new sex-determination proteins, the PLZF-like transcription factor TRA-4 and the F-box protein SEL-10; demonstrated that the neurogenesis genes vab-3 Pax6 and cnd-1 NeuroD are required for aspects of the CEM fate, including CEM death, and likely function together in this …
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Signalling pathway of FBXO7 and its role in hereditary Parkinsonism
… Fonzo et al., 2009). FBXO7 is a member of the F-box protein family, which functions as the variable subunit of Skp1-Cullin1-F-box protein (SCF) E3 ubiquitin ligase complexes and as such dictate substrate specificity. The canonical outcome of ubiquitylation is proteasomal degradation and my …
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Characterization of SCF Ubiquitin-Ligase Subunits in Arabidopsis
… of individual ASK:YFP auto-fluorescent fusion proteins expressed in vivo, as well as the in planta assessment of individual ASK-F-box protein interactions using BiFC. The results indicated significant functional divergence of steadystate transcript abundance and protein-protein interaction …
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Novel Posttranslational Modification In Lkb1 Activation and Function
… conserved metabolic sensor—AMP-activated protein kinase (AMPK). Activation of the LKB1/AMPK pathway provides a survival advantage for cells under energy stress. LKB1 forms a heterotrimeric complex and is activated through binding of the two regulatory proteins, STRAD and MO25. LKB1 has …
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Characterization of eid3 and the putative rei mutants : new insights on Phytochrome A signaling
… this SP condition. The EID1 gene codify for a F-box protein which is member of SCF - E3 ubiquitin ligase – complex. The SCFEID1 complex regulates the PhyA signal without impairing the photoreceptor levels (Dieterle et al., 2001). So far, the substrate which is recognized by the SCFEID1 complex …
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The discovery of a role of FBXO7/PARK15 in intracellular trafficking
… PARK-gene mutations. PARK15/FBXO7 encodes the F-box protein Fbxo7, which has a wide range of functions both as the substrate recruiting subunit of a Skp1-Cullin1-F-box (SCF) E3 Ubiquitin ligase complex and independent of SCF-binding. Known functions of Fbxo7 include regulation of mitophagy, the …
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Mechanisms of Controlled Proteolysis during Drosophila Spermatogenesis: Coordinate Action of Apoptotic Caspases and the Ubiquitin-Proteasome System
… to be tightly controlled, as many different proteins govern their transcription, stability, activation, and activity. Consequently, caspase regulation is extremely complex, and is further complicated by a discrepancy between different cell types and paradigms. Caspases have also been shown to …
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Identifikation und Regulation einer durch Insektenfraß induzierbaren Geranyllinalool-Synthase in Arabidopsis thaliana
… das Phytohormon Jasmonsäure, sowie das F-Box Protein COI1, das bislang noch nicht charakterisierte negative Regulatoren der Jasmonsäure-Signalkaskade dem Proteasom zuleitet. Salizylsäure und die Ethylen-Signalkaskaden haben keinen Einfluss auf die Induktion. Der Proteinsyntheseinhibitor …
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Ubiquitination of proteins involved in metabolism and immunomodulatory drug sensitivity in lymphocytes
Proteins undergo post-translational modifications, such as ubiquitination and phosphorylation, which can alter their activity, localisation and stability, making a cell responsive to its internal and external environment. Ubiquitin ligases and kinases comprise large enzyme families which catalyse …
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Understanding and Engineering Chemically Activated Ubiquitin Ligases for High-throughput Detection, Quantification, and Control of Molecules in Yeast
… as better understand the plant auxin co-receptor proteins from which it is built. Additionally, the biosensor is re-engineered for application in inducible protein degradation, controlled by auxin. This tool could be applied to identify novel protein targets for disrupting pathogenic fungal …
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STRUCTURAL AND FUNCTIONAL STUDIES OF F-BOX-ONLY PROTEIN FBXO7 AND ITS INTERACTIONS WITH PROTEASOME INHIBITOR PI31
F-box only protein 7 (Fbxo7), a member of the F-box-only subfamily of FBPs, is a biologically and pathophysiologically important human protein that assumes many critical functions. The different functions of Fbxo7 depend on the formation of various multi-protein complexes. Possible interplay …
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