Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"F-BAR"”.
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INTRACELLULAR PATTERN FORMATION OF F-BAR PROTEIN FBP17
… membrane and the appropriate curvature of F-BAR is crucial for membrane undulation and wave propagation. My results present a biological system where membrane-shape-mediated mechano-chemical feedback is critical for spatiotemporal pattern formation. This curvature-mediated coupling is a novel …
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Computational investigations of protein dynamics and its implication in cellular functions: two cases on membrane sculpting by protein complexes and molecular origin of Parkinson's disease
… approaches: membrane sculpting by F-BAR domains and transient β-hairpin structure in α-synuclein. Interplay between cellular membranes and their peripheral proteins drives many processes in eukaryotic cells. Proteins of the Bin/Amphiphysin/Rvs (BAR) domain family, in particular, play …
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Cip4 and Src In Promoting The Migration and Invasion of Breast Cancers
… rearragement. This represents a novel role for F-BAR proteins in migration and invasion.
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Toca-1 driven actin polymerisation at membranes
… (such as the PH domain in lamellipodin, or I-BAR protein in IRSp53) and a domain which interacts with actin regulatory proteins (such as the SH3 domain of IRSp53, which binds Ena and VASP). I investigated the contribution of the F-BAR protein Toca-1 in linking actin polymerisation to …
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Model Systems For Studies At The Plasma Membrane: Investigating Lipid Phase Behavior And Protein-Mediated Membrane Remodeling
… the activation mechanism of pacsin-1, an F-BAR domain protein enriched in neurons, by dynamin-1 PRD (prolinerich domain). While key basic residues in the PRD were vital to the activation of pacsin-1, we found that pacsin-1's membrane sculpting potential depends on membrane properties such as …
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Linking WRP/srGAP3 to the Cognitive Deficits in 3p- Syndrome and Its Role in the Regulation of Dendritic Filopodia Formation
… was found to contain a newly described inverse F-BAR (IF-BAR) domain of unknown function and to regulate cortical migration in developing neurons. This study focuses on the regulatory capacity of WRP during the development of neuronal connections in the central nervous system, and what role its …
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Regulation of synaptic structure and function at the Drosophila neuromuscular junction
… pathway. Nervous Wreck (Nwk) is a presynaptic F-BAR/SH3 protein that regulates synaptic growth signaling in Drosophila. Here, I show that Nwk acts through a physical interaction with Sorting Nexin 16 (SNX16). SNX16 promotes synaptic growth signaling by activated BMP receptors, and live imaging in …
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Dissecting Synaptic Vesicle Endocytosis
… phosphatase, calcineurin. Removal of the F-Bar domain protein syndapin 1, a dynamin 1 binding partner that requires dynamin 1s dephosphorylation, also distorted the acceleration. We examined the setpoint of synaptic vesicle endocytosis between boutons, between cells, and under different …