Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Ezrin"”.
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Evaluating CD44-EZRIN Interactions in Triple-Negative Breast Cancer: Tumourigenesis and Drug Resistance
… disease. The CD44 cell adhesion molecule and the Ezrin cytoskeletal adaptor protein have emerged as potential drivers of metastasis and drug resistance in cancers of the breast and other organs. Their known ability to physically interact, and their overlapping chemoresistance and metastasis …
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An investigation into dystroglycan deficiency in fibroblasts and a role for dystroglycan in cytokinesis
… found to co-localise with the ERM family member, ezrin. Expression of mutated and truncated dystroglycan-GFP constructs in dividing HeLa cells revealed that the cytoplasmic domain is required for cleavage furrow localisation, but ezrin-binding is not. A model for dystroglycan function at the …
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Risk Factors of Tumour Recurrence and Reduced Survival in Rectal Cancer
… expression of the tumour marker ezrin in primary tumours from patients with LR correlated to earlier occurrence of LR. A linkage of high ezrin expression and aggressive biological behaviour is suggested.
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UNDERSTANDING THE MOLECULAR BASIS OF CELL DEATH MEDIATED BY ONCOSIS-INDUCING CYTOTOXIC ANTIBODIES
… UNDERLYING CYTOSKELETON THROUGH INACTIVATION OF EZRIN, RADIXIN AND MEOSIN, AND PERTURBATION TO CYTOSKELETON ORGANIZATION THROUGH DEGRADATION OF ACTIN-ASSOCIATED PAXILLIN, TALIN AND ALPHA-ACTININ. THE RESULTANT MEMBRANE INJURY WAS LIKELY EXACERBATED BY THE LOSS OF MYOSIN II ACTIVITY NECESSARY FOR …
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Genetic and mechanistic determinants of prostate cancer progression and metastasis
… work have shown that loss of Protein 4.1B, a 4.1/ezrin/radixin/moesin (FERM) domain-containing cytoskeletal protein, is a frequent event in prostate cancer. The significance of this finding was confirmed by experimental ablation of 4.1B, which enhanced tumor progression and metastasis, at least in …
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Role of biomechanics and tumor microenvironment in osteosarcoma progression
… that the cytoskeletal linker and oncoprotein Ezrin is a potential mechanotransductor in osteosarcoma due to its exclusive nuclear localization and its association with metastatic cells and high-grade tumors. These findings add to the foundation of Ezrin being an attractive biomechanical target …
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Regulation of Cell Migration by WNK1
… re-organization including the ERM proteins (Ezrin, Moesin, and Radixin), cofilin, and the Rho family of GTPases, including RhoA and Rac1.
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Characterization of CEACAM1 Spatial Distribution, Self-association and Dynamics using High-resolution Microscopy Techniques
… CEACAM1 association to lipid-ordered regions, ezrin and actin. Finally, we present a set of preliminary methods and results that will serve to further the study of membrane protein clustering and self-association and their link to function. Together, this thesis aims to develop a more fulsome …
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Analysis of Band 4.1B In Integrin-Mediated Cell Adhesion and Signaling
… interacting with β1 integrin via its band 4.1, ezrin, radixin, and moesin (FERM) domain in cell adhesions. In astrocytes, both Band 4.1B and β1 integrin were expressed in cell-ECM contact sites during early cell spreading. Exogenous expression of Band 4.1B, especially its FERM domain, enhanced …
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Flourescent Biosensor-Based, Cdc42 Activity Imaging For Understanding the Regulation of Epidermal Growth Receptor (EGFR) Signalling in Head and Neck Cancer
… family (EGFR and HER2) and between PKCa and Ezrin, using FRET and FUM. The novel results from this thesis provides further knowledge on factors influencing EGFR downregulation in SCCHN, that could account for the resistance to EGFR targeted therapies observed in a clinical setting. In …
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Modeling mammary epithelial cell polarization and the role of podocalyxin in breast tumor progression
… its intracellular binding partners NHERF-1 and ezrin via its cytoplasmic tail. Strikingly, the formation of this protein complex was not required for microvillus formation. Additionally, podocalyxin delayed cell-cell aggregation and decreased the initial adhesion, spreading and strength of …
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The Role of Hippo Signalling in Merlin Null Tumours of the Nervous System
… surgical resection. The tumour suppressor Moesin-Ezrin-Radixin-Like Protein (Merlin) is deleted in 50-60% and 70% of meningiomas and schwannomas respectively. The Hippo pathway is an evolutionarily conserved pathway that has been shown to control tissue size by contactmediated growth inhibition. …
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Development of the chick chorioallantoic membrane (CAM) xenograft model to study metastasis and angiogenesis in autophagy deficient osteosarcoma cells
… metastatic gene expression (CXCR4, CCL5, EZRIN, FGF2, EGFR) was decreased by ~13.08-fold (p<0.05) on average in ATG7 CRISPR/Cas9 knocked-out HOS-143B tumours compared to WT HOS-143B tumours, and by ~9.21-fold on average compared to NC HOS-143B tumours. Interestingly, in vitro, ATG7 KO …
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Funktionelle Bedeutung der Protein-Kinase C eta im Infektionszyklus des autonomen Parvovirus Minute Virus of Mice
… der PKCeta -Aktivität und der Verteilung der Ezrin Radixin Moesin (ERM) -Proteine in vivo besteht, die mit PKCeta aus einem NS1-aktivierenden zellulären Extrakt über mehrere chromatographische Schritte zusammen aufgereinigt worden waren. Darüberhinaus kolokalisierte Radixin in …
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Funktionelle Analyse des murinen Foxq1 Gens und die Charakterisierung magenspezifischer Gene
… und Mäusen, denen das zur ERM Familie gehörige Ezrin fehlt, das eine Rolle in der Organisation des Plasmamembran-ständigen Aktinzytoskeletts spielt, liefern zusätzliche Hinweise auf die Beteiligung von Foxq1 an der Organisation des Aktinzytoskelett abhängigen Vesikeltransports bzw. der …
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Identification of proteins controlling gastrulation movements by a proteomic approach in zebrafish
… identified targets, several proteins, including Ezrin2, had previously been assigned a cytoskeleton-related function. I characterised Ezrin2 in more detail showing that Ezrin2 is specifically activated by phosphorylation in mesendodermal cells and that it is required for proper gastrulation …
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Zell- und molekularbiologische Charakterisierung neuartiger Zell-Zell-Verbindungsarten in Glioma-Zellen und mesenchymalen Stammzellen
… durch Actinfilament-Bündel in Verbindung mit Ezrin, alpha-Actinin und Myosin stabilisiert sind, andererseits aber auch Mikrotubuli enthalten. Solche Zellausläufer (Processus adhaerentes) können dabei sowohl über durch Puncta hergestellte Brückenstrukturen mit Ausläufern anderer Zellen …