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Showing 1 to 6 of 6 for “"Extrusion-spheronisation"”.
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Modified starch as an excipient for pellets prepared by means of extrusion/spheronisation
De focus van dit onderzoeksproject zijn pellets als farmaceutische doseringsvorm. Pellets worden gedefiniëerd als sferische partikels met goede vloei-eigenschappen en met een nauwe deeltjesgroottedistributie (voor farmaceutische toepassingen variërend tussen 500 en 1500 μm). Als multiparticulaire …
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Use of Aloe vera and Aloe marlothii materials as excipients in beads produced by extrusion–spheronization
… manufacture of spherical particles or beads by extrusion spheronisation. However, the use of MCC in beads has its limitations such as prolonged release of drugs due to lack of disintegration. The aim of this study was to determine if Aloe vera and Aloe marlothii leaf materials can be used as …
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The design and characterisation of multiparticulate lipidic systems for oral drug delivery
… matrix drug delivery system utilising extrusion spheronisation. The initial formulation supplied was Sebomin® MR 100mg capsules, an oral modified release commercial product. A technological transfer was undertaken to reproduce the Sebomin® multiparticulate product utilising lab-scale …
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Small scale manufacturing and scintigraphic detection of pellet formulations
… which were manufactured using either extrusion-spheronisation or the drug-layering techniques. Pelletisation methods were developed on a small scale in order to minimise quantities of radioisotope required for manufacturing for scintigraphic studies.Extrusion-spheronisation used …
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In vitro evaluation of the enzyme inhibition and membrane permeation properties of benzophenones extracted from honeybush
… divinylbenzene), which were prepared by means of extrusion spheronisation. The tablets were evaluated in terms of buoyancy, disintegration, friability, hardness and dissolution. Samples obtained from the transport and dissolution experiments were analysed by means of ultra-high performance liquid …
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Evaluation of the critical parameters and polymeric coat performance in compressed multiparticulate systems
Compression of coated pellets is a practical alternative to capsule filling. The current practice is to add cushioning agents to minimize the stress on the coated pellets. Cushioning agents however add bulkiness and reduce the overall drug loading capacity. In this study, we investigated the …