Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Extrinsic apoptotic pathway"”.
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Novel Role of CHK2 in the Intrinsic and Extrinsic Apoptosis Pathway
… stress, cells activate DNA damage checkpoint pathways that maintain genetic fidelity, promote cell survival, and prevent malignant transformation. Checkpoint kinase 2 (CHK2) is an evolutionarily conserved serine/threonine protein kinase that is activated in response to DNA double strand …
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Proteomic identification of putative biomarkers of radiotherapy resistance
… RR cell lines was carried out using Ingenuity Pathway Analysis (IPA) which identified canonical pathways associated with the data. Protein candidates from selected canonical pathways were confirmed by western blotting and assessed clinically using immunohistochemistry.ResultsFollowing the …
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Post-translational modifications of c-FLIP: opportunities for therapeutic intervention
FLIP is an anti-apoptotic protein found overexpressed in a wide variety of cancers and is associated with drug resistance and poor prognosis. It acts by inhibiting the membrane-proximal steps of death receptor-mediated apoptosis at the death inducing signalling complex (DISC), but also has roles in …
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The role of cardiolipin in the regulation of mitochondria-dependent apoptosis
… generation and as the site of key metabolic pathways. Over the past 15 years, it has become unequivocally clear that most pro-apoptotic stimuli require a mitochondria-dependent step, involving the permeabilisation of the mitochondrial outer membrane to apoptogenic factors, such as cytochrome …
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Antiproliferative activities of Euphorbia bicolor (euphorbiaceae) and Maclura pomifera (moraceae) extracts on estrogen receptor-positive and triple-negative breast cancer cell lines
… role of TRPV1. The extracts activated multiple apoptotic pathways, including mitochondrial, ERK-induced, and endoplasmic reticulum stress-mediated apoptotic mechanisms. Key apoptotic markers such as caspase 3, caspase 8, caspase 9, FADD, FAS, ATF4, and CHOP were upregulated, while antiapoptotic …
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Development of Novel Therapeutic Strategies for Pancreatic Cancer Treatment
… and metastasis by alteration of signaling pathways. Recent observations suggest the role of MUC13 in drug resistance and apoptosis in several cancer types. Therefore, it is of great interest to explore the role of MUC13 in chemoresistance in PanCa. Unlike other cancer types, PanCa is highly …