Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Extreme Phenotypes"”.
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Evaluating individuals with extreme phenotypes of HIV-1 contributes towards better healthcare management of all HIV-1 positive individuals
… (rapid progressors (RP)), representing the ‘extreme phenotypes’. There is substantial heterogeneity in how these phenotypes are defined, and we examined the relative merit of published definitions using data on HIV-1 seroconverters. We propose standard definitions for future research of these …
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Identifying Novel Contributors to RNA Interference in Aedes aegypti
… silencing abilities among individuals. Extreme EGFP expression phenotypes, representing efficient and poor silencing abilities, were enriched over five generations. Transcriptome sequencing and analyses were performed from pools of individuals from each enriched phenotype, revealing …
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Genetic studies of cardiometabolic traits
… ranging from studying clinically ascertained extreme phenotypes, deep molecular profiling, or sequence level data. In chapter 2, I investigated the genetic architecture of healthy human thinness (N=1,471) and contrasted it to that of severe early onset childhood obesity (N=1,456). I …
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Pharmacogenomics of warfarin: comprehensive evaluation of important warfarin genomic response factors
… black African individuals presenting with extreme phenotypes (i.e., very low dose or very high dose) but who did not harbour variants known to significantly affect warfarin dose requirements. A workflow which applied various bioinformatics tools was employed for the analyses of the …
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Alzheimer's disease: Age of Onset Modifier Genes in the World’s Largest Pedigree
… founder of the Paisa pedigree and exhibit an extreme phenotype based on the ADAOO for this population. Quality control, filtering, and functional annotation were applied prior to performing association analysis using the multi-locus linear mixed-effects model and collapsing methods to identify …
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Alzheimer's disease: Age of Onset Modifier Genes in the World’s Largest Pedigree
… founder of the Paisa pedigree and exhibit an extreme phenotype based on the ADAOO for this population. Quality control, filtering, and functional annotation were applied prior to performing association analysis using the multi-locus linear mixed-effects model and collapsing methods to identify …
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Genetic and functional studies in inherited platelet disorders
… rare variants (MAF <1%) are associated with extreme phenotypes and inherited platelet disorders (IPDs). The polygenic score (PGS) for platelet count is constructed from 739 common variants, explaining almost 20% of phenotypic variance. The accurate determination of effect sizes of rare …
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Old World Serpents and New World Dragons: The Evolutionary Dynamics of Pythons and Liolaemid Lizards
… reproductive mode and thermal niche, but are extremely species rich, with almost 300 currently recognized species. Both pythons and liolaemid lizards, based on different and common attributes, have been recognized as examples of an adaptive radiation. My research on pythons is summarized in …
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Old World Serpents and New World Dragons: The Evolutionary Dynamics of Pythons and Liolaemid Lizards
… reproductive mode and thermal niche, but are extremely species rich, with almost 300 currently recognized species. Both pythons and liolaemid lizards, based on different and common attributes, have been recognized as examples of an adaptive radiation. My research on pythons is summarized in …