Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Extraembryonic endoderm"”.
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A multi-lineage in vitro mouse embryo model derived exclusively from mouse embryonic stem cells
… egg cylinder consisting of the epiblast (EPI), extraembryonic ectoderm (ExE) and visceral endoderm (VE), which give rise to the embryo proper, placenta and yolk sac respectively. By using stem cells derived from these three fundamental lineages, many *in vitro* models have been developed to …
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Dissecting Pluripotency and Mammalian Embryonic Development via Droplet Microfluidics
… the microgel system to co-encapsulate ESCs with extraembryonic endoderm (XEN) cells. Co-encapsulation of these cell types led to the formation of self-organising aggregates in which the XEN cells surrounded an inner core of ES cells. These aggregates, termed EX-structures, exhibited deposition of …
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An in vitro model of human yolk sac and epiblast crosstalk
… signalling interactions between embryonic and extraembryonic lineages. Improved embryo culture techniques have recently allowed human embryos to be cultured in vitro past the point at which they would implant in vivo, until the internationally accepted culture limit of 14 days. Nonetheless, the …
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Human Embryonic Stem Cells - Constitutive Gene Expression and Differentiation Towards Definitive Endoderm and Posterior Foregut Endoderm
… research tools. Identification of definitive endoderm (DE) - from where pancreas originates, requires analysis methods that can detect multiple markers within individual cells, since many markers expressed in DE are also detected in extraembryonic endoderm. In this thesis, we approached single …
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The Role of NADPH Oxidase in ROS Mediated Differentiation
… F9 cells differentiate into primitive endoderm (PrE) when treated with retinoic acid (RA) or H2O2 and these changes are accompanied by an upregulation of Wnt6 and activation of the canonical WNT/β-catenin pathway. Data from our lab shows PrE differentiation is accompanied by an increase …