Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 97 for “"Extracellular vesicles (EVs)"”.
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Role of extracellular vesicles(EVs) in mediating cell-to-cell signaling during early pregnancy
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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Investigating Human Cell Influence on the Micromechanical Environment of a 3D-Printed Bone Tissue Model
… survival in the bone niche remain underexplored. Extracellular vesicles (EVs) are membrane-bound particles that facilitate intercellular communication between cancer and bone cells to form pre-metastatic niches, infiltrate tissue systems, and promote survival. Current models, such as 2D in vitro …
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Brain-derived Extracellular vesicles as biomarkers of Parkinson’s disease
… relatively invasive. In contrast, brain-derived extracellular vesicles (EVs) are found to be in substantial concentrations in systemic circulation, allowing for the possibility of a diagnostic blood test. In this study, we demonstrate that a higher concentration of alpha synuclein (aSyn) and …
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Extracellular Vesicles to Evaluate the Effects of Mesenchymal Stromal Cells in the Premature Lung
… lung remain unclear, we hypothesized that extracellular vesicles (EVs) might reflect MSC effects. We analyzed EVs from tracheal aspirates (TA) collected before and after MSC treatment using two flow cytometry methods: antibody-capture to identify cellular origin and single particle analysis …
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Biochemical characterizations of extracellular vesicles shed by vegetative and sporulating Bacillus subtilis
… environments. Recently, biogenesis of extracellular vesicles (EVs) from Bacilli has also been reported to participate in various physiological and pathogenic phenomena. In this study, EVs were isolated from vegetative and sporulating Bacillus subtilis cells and characterized using mass …
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Development of Strategies for Improving the Isolation Efficiency and Protein Quantification of Extracellular Vesicles
Studies have shown that extracellular vesicles (EVs) are involved in the development of many diseases. Because EVs are released in body fluids, analysis of their protein content can potentially be used as diagnostic and prognostic tools. In this thesis, efficient and simple strategies to improve …
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Investigating the translational and metabolic reprogramming of the bone marrow niche in myeloid malignancy
… machinery that is transferred to AML cells via extracellular vesicles (EVs), to meet their translational demands. In two independent models of highly chemo-resistant AML driven by MLL-AF9 or FLT3-ITD;NPMc mutations, we show that AML protein synthesis levels increase at relapse dependently on …
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PATIENT-DERIVED ORGANOIDS AND EXTRACELLULAR VESICLES: UNLOCKING NEW FRONTIERS IN BREAST CANCER DRUG TESTING AND BIOMARKER DISCOVERY
… in monitoring disease progression by analyzing Extracellular vesicles (EVs). EVs could help stratify patients by risk, allowing for targeted treatment. Despite their potential, traditional quantification methods remain challenging, necessitating further research to identify specific and reliable …
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Human neutrophils generate extracellular vesicles that modulate their functional responses
… and chemokines, by generating neutrophil extracellular traps (NETs), and by modulating their own survival. Neutrophils also produce extracellular vesicles (EVs) termed ectosomes, which influence the function of other immune cells. Here, we studied neutrophil-derived ectosomes (NDEs) and …
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PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9, ATHEROSCLEROSIS AND EXTRACELLULAR VESICLES ¿ EXPERIMENTAL AND CLINICAL EVIDENCE
… molecules, some of which are packed into extracellular vesicles (EVs). Proprotein convertase subtilisin/kexin type 9 (PCSK9) is expressed and secreted by VSMCs. This study aimed to unravel the role of PCSK9 on VSMCs-derived EVs in terms of content and functionality. EVs were isolated from …
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Exosome Prevention of Post Operative Atrial Fibrillation
… In this study, we tested the concept that extracellular vesicles (EVs) isolated from human atrial explant-derived cells can prevent post-operative AF. Middle-aged female and male rats were randomized to undergo sham operation or induction of sterile pericarditis followed by trans-epicardial …
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LIQUID BIOPSY IN GLIOBLASTOMA (GBM)CHARACTERIZATION OF PLASMA EXTRACELLULAR VESICLES CONCENTRATION, SIZE AND CARGO FOR NON-INVASIVE GBM DIAGNOSIS, MONITORING AND IDENTIFICATION OF CIRCULATING BIOMARKERS
… biopsy, particularly through the analysis of Extracellular Vesicles (EVs), offers a promising avenue. We isolated EVs from 2 mL of plasma using Size Exclusion Chromatography and assessed their concentration and size with Tunable Resistive Pulse Sensing. We observed increased plasma EV levels …
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Profiling extracellular vesicles signatures and deiminated protein cargo across phylogeny and pilot assessment of in vitro application of EVs in tissue regeneration, with focus on selected taxa displaying unusual immunological properties.
Extracellular vesicles (EVs) are small membrane-bound structures secreted by cells that have emerged as key mediators of intercellular communication, carrying a diverse cargo of proteins, lipids, and nucleic acids that regulate various physiological processes. This thesis presents a comprehensive …
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Elucidating the Relation between Human Milk Fatty Acids, Extracellular Vesicles, and Infant Developmental Outcomes in the First Year of Life
… body, and therefore must be consumed in diet. Extracellular vesicles (EVs) are nanoparticles containing a lipid bilayer membrane and are present in human milk. Methods of EV isolation such as ultracentrifugation (UC) may not be feasible for the study of EVs in human milk due to the need for …
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DEVELOPMENT OF A 3D ZWITTERIONIC HYDROGEL SYSTEM FOR CELL CULTURE AND EXTRACELLULAR VESICLES
Since the release of Extracellular vesicles (EVs) has been recognized as a common method of intercellular communication between cells, they are essential in various biological processes and possess significant therapeutic potential. Maintaining high-quality control of donor cell cultures and EVs is …
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Molecular mechanisms of exosome secretion
Exosomes are small (30-150 nm) extracellular vesicles (EVs) that obtain their membrane through the inward invagination of the endosomes, which are known as multivesicular endosomes (MVEs). Exosomes are secreted to the extracellular milieu when MVEs dock and fuse with the plasma membrane. However, …
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Identification of surface accessible proteins in parasitic nematode extracellular vesicles
Extracellular vesicles (EVs) are membrane-bound nanoparticles released by the cells of many organisms, containing important biological molecules including bioactive proteins, lipids, and nucleic acids. EVs are shed by parasitic nematodes into the host environment and have been shown to play a …
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Characterization of Free Oxylipins in Extracellular Vesicles from Bovine Milk
<p>Background. Extracellular vesicles (EVs) are membrane-bound nanostructures released by human and bovine mammary epithelial cells that carry bioactive lipids and oxidized lipid metabolites. Found in bovine milk, EVs contribute to immune modulation, gut health, and cellular signaling. However, …
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High Frequency Irreversible Electroporation (H-FIRE) as a Therapeutic Modality for Liver Cancer Treatment and Its Effect on the systemic Extracellular Vesicle Population
… suggests H-FIRE may impact the release of extracellular vesicles (EVs). This study aims to explore how H-FIRE affects peripheral extracellular vesicle (EV) dynamics, potentially providing insights into its broader systemic effects and implications for biomarker development in canine liver …
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Extracellular Vesicles as Mediators of Communication Between Endothelial Cells and Fibroblasts
… mode of intracellular communication is through extracellular vesicles (EVs), capable of transferring regulatory molecules such as microRNAs (miRNAs) to nearby or distant cells. This study investigated whether EVs secreted by human dermal microvascular endothelial cells (EC-EVs) influence …
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