Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Extracellular vesicle"”.
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Extracellular Vesicle Capture and microRNA Detection
… accessible biomarkers via liquid biopsies. Extracellular vesicles have shown promise as a noninvasive biomarker for disease diagnosis and monitoring, and have become a treasure trove of information because they have been found to carry proteins, DNA, mRNA and microRNA as well surface markers …
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Mutant Kras Alters Extracellular Vesicle Microrna Sorting In Pancreatic Cystic Neoplasms
… effect of <em>KRAS</em> on loading of cargo into extracellular vesicles (EVs). EVs are released into body fluids by normal and pre-malignant/malignant cells, which, by virtue of their function involvement in intercellular communications, play critical roles in the development and progression of …
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Impact of human blood plasma-derived protein corona on extracellular vesicle uptake
… different types of phospholipid bilayer-limited vesicles into the extracellular space. These are commonly referred to as extracellular vesicles (EVs). Exosomes (EXOs), ca 50-100 nm in diameter and microvesicles (MVs), ca 100-1000 nm in diameter, having different intracellular origin, are the two …
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Development of an extracellular vesicle therapy to recover skeletal muscle after disuse
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms
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Mechanisms Underlying Mesenchymal Stem Cell-Derived Extracellular Vesicle Modulation of Sensory Neuron Excitability
… highlights the critical role of MSC-derived extracellular vesicles (EVs), which facilitate the transfer of biomolecular cargo between cells. Our previous work demonstrated that MSC-EVs alleviate pain in a murine model of OA by reducing OA-induced sensory neuron hyperexcitability, rather than …
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Engineering Small Extracellular Vesicle-Derived Vehicles Carrying Optimized microRNA for Cardiac Repair after Myocardial Infarction
… One promising therapy involves delivering small extracellular vesicles (sEVs). These sEVs are 30-150 nm vesicles containing protein and/or nuclear cargo. Despite their reparative potential, sEV therapies have several issues due to their cellular origin, including variable sEV yield and …
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Obesity-Induced Alterations in Sperm Quality, Testicular Morphology, and Extracellular Vesicle Localisation in Male Mice
… spermatogenesis and reduced sperm function. Extracellular vesicles (EVs), which facilitate cell-to-cell communication, have been discovered in various biological fluids. Specifically, in the male reproductive system, testicular-derived EVs have been reported to regulate testosterone …
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Development of Bioelectronic Technologies for the Investigation of Extracellular Vesicle Function and Anti-Cancer Drug Discovery
Extracellular vesicles (EVs) are cell-secreted phospholipid bilayer-delimited particles of varying size and composition that facilitate intercellular communication. EVs play a critical role in a wide range of diseases by mediating the transfer of active biomolecules between cells, both in the …
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Development of a pericyte-derived extracellular vesicle therapy for the recovery of skeletal muscle mass following immobilization
… processes such as angiogenesis, myogenesis and extracellular matrix (ECM) remodeling. Pericyte intramuscular transplantation concurrent with 4 weeks of electrical stimulation significantly increased collagen remodeling and muscle capillarization. Lastly, intramuscular transplantation of …
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Inhibition of extracellular vesicle release enhances cancer chemotherapy and inhibition of outer membrane vesicle release sensitises bacteria to antibiotic and bacteriophage therapy
Extracellular vesicle (EV) release from tumour cells plays an important role in cancer drug resistance. It is essential that chemotherapeutic drugs are retained within target cells for increased efficacy in inducing apoptosis and as microvesiculation influences drug retention, this study has …
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High Frequency Irreversible Electroporation (H-FIRE) as a Therapeutic Modality for Liver Cancer Treatment and Its Effect on the systemic Extracellular Vesicle Population
… suggests H-FIRE may impact the release of extracellular vesicles (EVs). This study aims to explore how H-FIRE affects peripheral extracellular vesicle (EV) dynamics, potentially providing insights into its broader systemic effects and implications for biomarker development in canine liver …
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Discovery of Novel Mechanisms Regulating Cancer Extravasation in the Chorioallantoic Membrane Model
… found that cancer cell released extravascular vesicles during extravasation, and an increase in extracellular vesicle release reduced cell volume. I then tested the hypothesis that extracellular vesicle release and extravasation may be linked to modes of cell death. Real-time imaging of …
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Understanding Virulence Mechanisms of Parasitoid Wasps of Drosophila: A Comparative Approach Across Clades
… genus <em>Leptopilina</em> are known to produce extracellular vesicle (EV)-like secretions in their venom. Well-characterized in <em>L. heterotoma</em>, these vesicles kill host hemocytes, respectively, such that the encapsulation response in <em>D. melanogaster</em> is suppressed. A putative …
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A study of bioprocess designs for development of the myogenic secretome as a source of bioactive extracellular vesicles
… involved quantification of secretome yield and extracellular vesicle (EV) characterisation. Internalisation of myogenic EVs by human chondrocytes was investigated to examine bioactivity. Effects of EVs on matrix metalloproteinase-13 and nuclear factor-κB gene expression and EV ability to limit …
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Human mesenchymal stromal cell regulation of pulmonary macrophage populations in the Acute Respiratory Distress Syndrome
… phagocytic capacity. Blocking hMSC-derived extracellular vesicle (EV) uptake by human macrophages using anti-CD44 antibody reversed these effects. Moreover, the adoptive transfer of murine AMs which had been pre-treated with hMSC-derived EVs was protective in endotoxin-induced lung injury in …
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NANOFLUIDIC ISOLATION AND QUANTIFICATION OF SPECIFIC EXTRACELLULAR VESICLES AND MACHINE LEARNING ANALYSIS TO AID CLINICAL DECISION-MAKING
Extracellular vesicles (EVs) hold immense promise as reservoirs of critical biomarkers for diagnosing and prognosing various diseases. However, leveraging their potential in clinical settings faces significant obstacles, including precise detection, quantification, and isolation of specific EV …
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Investigating the role of microRNAs and extracellular vesicles in cisplatin resistance in ovarian cancer
… in physiological and pathological conditions. Extracellular Vesicle (EV) communication between cells could also play a noteworthy role in cisplatin resistance. The main aim was to identify microRNAs involved in cisplatin resistance in ovarian cancers whose role in this aspect has not been …
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