Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"Extracellular matrix remodeling"”.
-
Effects of Asthma Combination Therapy on Extracellular Matrix Remodeling in Human Lung Fibroblasts
… to produce inflammatory mediators, cytokines and extracellular matrix (ECM) proteins perpetuating the inflammation in the airways of asthmatics. Airway remodeling is also a prominent feature of asthma that affects the lung function causing a thickening of the airways. An increased ECM production …
-
Sex Specific Gene Expression Profiles In Fibrosis and Copd
… number of genes related to immune regulation and extracellular matrix remodeling, important events involved in IPF and COPD, have been measured in lung cells and tissues however limited investigations have probed the expression of genes related to steroid hormone signaling between men and women. …
-
Purification and Characterization of an Anti-Basigin Monoclonal Antibody: Application to the Study of Human Uterine Cells and Tissues
… functions, including cell communication and extracellular matrix remodeling (Chen et al., 2009; K. Li & Nowak, 2020). <em>In vitro</em> studies using human uterine cells demonstrate that basigin-2 regulates the expression and secretion of enzymes called matrix metalloproteinases, which are …
-
An immune-competent microvascularized human lung-on-chip device for studying immunopathologies of the lung
… infection results in significant lymphopenia, extracellular matrix remodeling, and transcriptional shutdown in fully immune-competent lung tissues. Lastly, we highlight the prominent role of stromal-immune interactions in the response to severe influenza infection, with stromal cells …
-
Lesioni degenerative e meccanismi di riparo della superficie oculare: lo pterigio e le deficienze delle cellule staminali del limbo (LSCD). Studio immunoistochimico e tecniche di coltura cellulare
… infiltrates, fibrosis, angiogenesis and extracellular matrix remodeling. The Angiotensin converting enzyme (ACE or ACE I) is the major component of the Renin-angiotensin system (RAS) converting the inactive decapeptide Angiotensin I (Ang I) to the active octapeptide Angiotensin II (Ang …
-
Skeletal muscle pericyte response to acute and chronic electrical stimulation
… for myogenesis, satellite cell activation, and extracellular matrix remodeling post-acute stimulation. Finally, a pericyte to MSC transition was also observed with 4 weeks of stimulation, but no changes in overall pericyte quantity were noted at 4 or 9 weeks. CONCLUSION: This study provides …
-
Quantitative estimates of mechanical properties from in vivo tumors of rodent animals
… into malignant processes characterized by extracellular matrix remodeling and stiffening. This thesis focuses on using ultrasonic tools to image shear waves generated in spontaneous rodent mammary tumors to estimate the complex shear modulus under realistic conditions, and to assess the …
-
Regulation and inhibition of pro-tumorigenic microenvironments
… including endothelial cells, immune cells, the extracellular matrix and fibroblasts can all assume a pro-tumorigenic phenotype.</p><p>Like cancer-associated fibroblasts (CAFs), senescent cells promote all stages of tumor development and progression. We and others have demonstrated that senescent …
-
Multi-Omics Analysis of 3D SKOV3 Ovarian Cancer Model Cell line Cultured on Novel Silicon-Titanium Diboride Micropatterned Substrate
… so, important features like cell-cell and cell- matrix interactions are not properly represented. Gene expression, metabolism, and cell proliferation are altered in 2D culture systems. Unlike the conventional 2D culture systems, 3D culture systems better recapitulate the in vivo architecture and …
-
Single-cell Analysis of Structural and Immune Cell Interactions in Periodontitis
… transcriptional signatures consistent with extracellular matrix remodeling, vascular regulation, and stress adaptation, while immune cells exhibited sustained activation of inflammatory and cytokine-mediated pathways. Importantly, overlapping transcriptional programs across structural and …
-
Adipose Tissue And Its Role In Modulating The Mammary Tumor Microenvironment
… cells and adipocytes possibly partake in extracellular matrix (ECM) remodeling and blood vessel recruitment. Both tumor-associated ECM remodeling and neovascularization are typically mediated by myofibroblasts, which are known to be recruited or differentiated from other stromal cells. …
-
Exploring the Multifaceted Life of Beige Adipocytes
… monocyte-recruitment, likely triggered by extracellular matrix remodeling driven by local adipocyte subtypes. Together, our findings offer important insights into the developmental and functional complexity of beige adipocytes, from their origins and molecular identity to their role in …
-
CHCHD2 and the tumor microenvironment in glioblastoma
… intracellular metabolic stress imposed by the extracellular tumor microenvironment and respond appropriately by relaying their status to the nucleus, thus inducing changes in gene expression and facilitating cellular adaptation. The focus of this work is on the mitochondrial protein …
-
MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… nitric oxide synthase (iNOS), the activation of matrix metalloproteinases (MMPs) and mitogen activated protein kinase (MAPK) pathway because microarray work [8] and published data [9] primarily pointed at these. These parameters and the relationships between them were studied in the …