Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Extracellular matrix components"”.
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Effects of adipose tissue extracellular matrix components on body fat distribution and insulin sensitivity in black and white South African women
… examine the hypothesis that differences in SAT extracellular matrix (ECM)- and hypoxia-related gene expression and their ethnic specific associations with body composition and insulin sensitivity may explain, in part, the higher rates of insulin resistance in black compared to white South …
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The Role of the Extracellular Matrix components of Salmonella enterica serovar Typhimurium Biofilms in Biofilm Formation and Architecture via in vitro analysis
… bacterial cells enclosed within a self-generated extracellular matrix, forming a three-dimensional structure that allows the bacteria cells to firmly attach to both living and non-living surfaces. The extracellular matrix of Salmonella enterica serovar Typhimurium (STm) biofilms is composed of …
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The streptococcal collagen-like protein-1 (Scl1) is a multifunctional adhesin in extracellular matrix interactions, biofilm formation, and host colonization by group A Streptococcus
… accessibility to exposed host cell surfaces and extracellular matrix components create a model milieu for successful host colonization and potential biofilm formation. The initiation of biofilm is often mediated by bacterial surface adhesins and has been shown to interfere with wound healing by …
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DETECTION OF SECRETED PROTEASES AND A MEMBRANE PROTEASE IN PATHOGENIC ACANTHAMOEBA CULBERTSONI
… infections include amoebic interaction with host extracellular matrix (ECM) components as requisites for both attachment to, and subsequent invasion of, host tissues to facilitate disease establishment. Previous studies have demonstrated that pathogenic species of Acanthamoeba , such as …
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Estudo histoquímico e ultra-estrutural das fibras do sistema colágeno na glândula de veneno de Bothrops jararaca (Wied, 1824) (Reptilia, Squamata)
… objective of this thesis was to identify some extracellular matrix components of the intertubular septa, in the different time setting of the cycle after venom extraction. Electron microscopic findings have confirmed the optical ones. After milking the secretory epithelium has changed to …
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The Role of Pax6 in Lens Placode Formation
… deleting the transcription factor, Pax6, or the matrix component, Fn1. Deletion of Pax6 from the lens-forming ectoderm prevented placode formation without altering cell proliferation or volume. <italic>Pax6<super>CKO</super> </italic>ectoderm expanded, rather than being constrained to a constant …
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Fibroblast Regional Identity in the Murine Lymphoid System
… most abundant cell type of the stroma, producing extracellular matrix components which provide mechanical strength to tissues. Recent work has shown that fibroblasts are not simply passive structural cells but active participants in the immune response. In this study fibroblast heterogeneity …
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Effect of Anti-fibrotic Drug (Pirfenidone) on TGF-β Signaling Pathway in Ocular Fibrotic Disorders
… protein kinase, c-Jun N-terminal kinase, and extracellular signal related kinase expression were conducted to elucidate the cell signaling networks that contribute to the anti-fibrotic effect of pirfenidone. Results: Treatment with TGF-β1 induced typical phenotypic changes such as formation of …
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The Role of Reactive Oxygen Species in Crotalus atrox Venom-induced Cell Death
… venom also causes a loss of cellular adhesion to extracellular matrix components resulting in massive local tissue damage. To better understand the mechanism in which venom induces local tissue damage, human embryonic kidney cells (HEKS) were grown on PEI then stimulated with 500μg/ml <em>Crotalus …
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Defining the Developmental Signals of the Cardiac Fibroblast
… and fibrotic response and also secrete extracellular matrix components that provide structural support for regeneration and remodeling of the wound. Despite the importance of the cardiac fibroblast in heart disease, very little is known about factors that are essential for …
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Stromal Fibroblasts Restrain The Rate of Colon Cancer Progression and Metastasis By Suppressing Regulatory T Cells and Colon Cancer Stem Cells
… cells, fibroblasts, endothelial cells, and extracellular matrix components (ECM). Fibroblasts are ubiquitous stromal cells that can influence other neighboring cell types through the secretion of chemokines, cytokines, ECM, ECM remodeling enzymes, and other metabolites. Myofibroblasts are a …
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Understanding protease-mediated host-pathogen interactions in <i style="">Proteus mirabilis</i>
… structural proteins such as cytoskeletal and extracellular matrix components, and immunoproteins such as immunoglobulins, complement and antimicrobial peptides. The work in this thesis has further elucidated the immunomodulatory role of ZapA. Purification of native, proteolytically active ZapA …
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Exploration of novel activin A antibodies
… growth factor domain. Through interactions with extracellular matrix components, pro-domains facilitate growth factor storage, localisation, and activation through mechanisms driven by distinct structural properties. Activin A is a TGF-β growth factor essential to development and healthy tissue …
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Mechanisms of Copper-Dependent Notochord Formation in Zebrafish
… essential roles for copper and multiple extracellular matrix components in late notochord formation and suggest that nutritional status should be interpreted within the polymorphic genetic context of the developing embryo.
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A COMPARATIVE STUDY OF A PATHOGENIC VERSUS A NONPATHOGENIC NAEGLERIA SPECIES
… from nonpathogens. Therefore, adhesion to extracellular matrix components (ECM), laminin-1, fibronectin, and collagen I, was assessed. N. fowleri exhibited a higher level of adhesion to ECM components and was shown to invade tri-dimensional ECM scaffolds (matrigel and collagen I) to a …
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The Immunopathogenesis of HLA B27-associated Spondylarthritis and Acute Anterior Uveitis
… an inflammatory response. Lumican is an extracellular molecule that is found in both the eye and joint and has important structural, functional and immunological functions. This study showed that lumican was present in the aqueous humor of eyes in patients with AAU. Furthermore, …
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Interactions of Francisella Tularensis With Components of the Host Fibrinolytic System
… FT research of late has shown an abundance of extracellular bacteria in the plasma fraction of host's blood during infection. The goal of these studies was to identify and characterize the interactions of <em>Francisella tularensis</em> with components of the host fibrinolytic system.</p> …
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Aligned Fibrillar Collagen Matrices for Tissue Engineering
… this thesis investigated methodologies to align extracellular matrix structures in vitro to guide stem/progenitor cell behaviour for tissue regeneration. Aligned collagen fibrils were deposited on planar substrates from collagen solutions streaming through a microfluidic channel system. Collagen …
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