Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 41 for “"Extracellular matrix components"”.
-
Effects of adipose tissue extracellular matrix components on body fat distribution and insulin sensitivity in black and white South African women
… examine the hypothesis that differences in SAT extracellular matrix (ECM)- and hypoxia-related gene expression and their ethnic specific associations with body composition and insulin sensitivity may explain, in part, the higher rates of insulin resistance in black compared to white South …
-
The Role of the Extracellular Matrix components of Salmonella enterica serovar Typhimurium Biofilms in Biofilm Formation and Architecture via in vitro analysis
… bacterial cells enclosed within a self-generated extracellular matrix, forming a three-dimensional structure that allows the bacteria cells to firmly attach to both living and non-living surfaces. The extracellular matrix of Salmonella enterica serovar Typhimurium (STm) biofilms is composed of …
-
The streptococcal collagen-like protein-1 (Scl1) is a multifunctional adhesin in extracellular matrix interactions, biofilm formation, and host colonization by group A Streptococcus
… accessibility to exposed host cell surfaces and extracellular matrix components create a model milieu for successful host colonization and potential biofilm formation. The initiation of biofilm is often mediated by bacterial surface adhesins and has been shown to interfere with wound healing by …
-
Inhibition der Tumorzelladhäsion an Extrazellularmatrixkomponenten durch Phospholipide in vitro
… tumors. Adhesion of tumor cells to extracellular matrix components is a pivotal step in developing peritoneal dissemination of intraabdominal malignancies. Since phospholipids efficaciously prevent peritoneal adhesion formation in numerous animal studies we investigated their …
-
DETECTION OF SECRETED PROTEASES AND A MEMBRANE PROTEASE IN PATHOGENIC ACANTHAMOEBA CULBERTSONI
… infections include amoebic interaction with host extracellular matrix (ECM) components as requisites for both attachment to, and subsequent invasion of, host tissues to facilitate disease establishment. Previous studies have demonstrated that pathogenic species of Acanthamoeba , such as …
-
Estudo histoquímico e ultra-estrutural das fibras do sistema colágeno na glândula de veneno de Bothrops jararaca (Wied, 1824) (Reptilia, Squamata)
… objective of this thesis was to identify some extracellular matrix components of the intertubular septa, in the different time setting of the cycle after venom extraction. Electron microscopic findings have confirmed the optical ones. After milking the secretory epithelium has changed to …
-
The Role of Pax6 in Lens Placode Formation
… deleting the transcription factor, Pax6, or the matrix component, Fn1. Deletion of Pax6 from the lens-forming ectoderm prevented placode formation without altering cell proliferation or volume. <italic>Pax6<super>CKO</super> </italic>ectoderm expanded, rather than being constrained to a constant …
-
Fibroblast Regional Identity in the Murine Lymphoid System
… most abundant cell type of the stroma, producing extracellular matrix components which provide mechanical strength to tissues. Recent work has shown that fibroblasts are not simply passive structural cells but active participants in the immune response. In this study fibroblast heterogeneity …
-
Effect of Anti-fibrotic Drug (Pirfenidone) on TGF-β Signaling Pathway in Ocular Fibrotic Disorders
… protein kinase, c-Jun N-terminal kinase, and extracellular signal related kinase expression were conducted to elucidate the cell signaling networks that contribute to the anti-fibrotic effect of pirfenidone. Results: Treatment with TGF-β1 induced typical phenotypic changes such as formation of …
-
Etablierung adenoviraler Genexpression zum antifibrotischen Einsatz bei der Leberfibrose
… imbalance between synthesis and degradation of extracellular matrix components due to a variety of deseases such as virus hepatitis, alcoholic abuse or metabolic dysfunction. The cytokine TGF-ß plays an important role in so far it interferes during hepatic injury with the transcriptional …
-
The Role of Reactive Oxygen Species in Crotalus atrox Venom-induced Cell Death
… venom also causes a loss of cellular adhesion to extracellular matrix components resulting in massive local tissue damage. To better understand the mechanism in which venom induces local tissue damage, human embryonic kidney cells (HEKS) were grown on PEI then stimulated with 500μg/ml <em>Crotalus …
-
Defining the Developmental Signals of the Cardiac Fibroblast
… and fibrotic response and also secrete extracellular matrix components that provide structural support for regeneration and remodeling of the wound. Despite the importance of the cardiac fibroblast in heart disease, very little is known about factors that are essential for …
-
Stromal Fibroblasts Restrain The Rate of Colon Cancer Progression and Metastasis By Suppressing Regulatory T Cells and Colon Cancer Stem Cells
… cells, fibroblasts, endothelial cells, and extracellular matrix components (ECM). Fibroblasts are ubiquitous stromal cells that can influence other neighboring cell types through the secretion of chemokines, cytokines, ECM, ECM remodeling enzymes, and other metabolites. Myofibroblasts are a …
-
Understanding protease-mediated host-pathogen interactions in <i style="">Proteus mirabilis</i>
… structural proteins such as cytoskeletal and extracellular matrix components, and immunoproteins such as immunoglobulins, complement and antimicrobial peptides. The work in this thesis has further elucidated the immunomodulatory role of ZapA. Purification of native, proteolytically active ZapA …
-
Exploration of novel activin A antibodies
… growth factor domain. Through interactions with extracellular matrix components, pro-domains facilitate growth factor storage, localisation, and activation through mechanisms driven by distinct structural properties. Activin A is a TGF-β growth factor essential to development and healthy tissue …
-
Application of fluorescence resonance energy transfer to study syndecan-3 signaling on the surface of neural cells
… and control relocation and alteration of extracellular matrix components. Syndecans regulate cell migration, adhesion and proliferation and are engaged in tissue injury, inflammation processes, pathogenesis of infectious diseases and tumor biology. This thesis summarizes the results of …
-
Interactions of Francisella Tularensis With Components of the Host Fibrinolytic System
… FT research of late has shown an abundance of extracellular bacteria in the plasma fraction of host's blood during infection. The goal of these studies was to identify and characterize the interactions of <em>Francisella tularensis</em> with components of the host fibrinolytic system.</p> …
-
Reduktion der intraperitonealen Adhäsion humaner Magenkarzinomzellen in Nacktmäusen
… Adhesion of tumour cells to mesothelial cells or extracellular matrix components is a pivotal step in developing peritoneal dissemination after gastric cancer. As phospholipids were found to reduce adhesion formation, especially at sites of peritoneal lesions(1) we assessed the inhibition of …
Page 1 of 3