Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Extracellular fluid"”.
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Extracellular Fluid Systems in the Brain and the Pathogenesis of Hydrocephalus
… related to the locations of Cerebrospinal Spinal Fluid (CSF) absorption deficit and causes of the pressure gradients that expand the ventricles with hydrocephalus remain largely unanswered. Work in the Johnston lab over a 15 year period has demonstrated that CSF moves through the cribriform plate …
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A holistic multi-scale mathematical model of the murine extracellular fluid systems and study of the brain interactive dynamics
… regarding the interaction and functional role of fluid compartments in the central nervous system have attracted the attention of many researchers across various disciplines. Neurotoxins are constantly cleared from the brain parenchyma through the intramural periarterial drainage system, …
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Quantifying fluid overload with portable magnetic resonance sensors
… specifically for the purpose of quantifying fluid overload. MRI is used extensively in clinical medicine, but it is still not used for routine diagnostics due to high cost, limited availability, and long scan times. Many of these impracticalities come from the hardware requirements associated …
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Age-related impairments in memory and in cholinergic signaling due to reduced blood glucose responses to epinephrine
… epinephrine and becomes severely depleted in the extracellular fluid of the hippocampus during a cognitively demanding task, contributing to poor memory. Glucose supplementation restores extracellular fluid levels of glucose and reverses the associated memory impairments. The present work examines …
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Studies on the characterization of a soluble factor of a sodium-activated, magnesium-dependent adenosinetriphosphatase in rat cerebral cortex
… of the animal cell differs from its external fluid environment.</p><p>It is well know that where sodium is the principal cation of the extracellular fluid, potassium has such a role inside the cell. Since there appears to be differential distribution of these ions across the cell membrane, …
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Studies on the Role of Vitamin D in the Mineralization of Bone: A Vitamin D-dependent Serum Protein That Stimulates the Incorporation of 45 Calcium by Bone Cells in Vitro
… on an adequate supply of Ca+2 and HP04-2 ions in extracellular fluid for the spontaneous precipitation of bone mineral. The impaired mineralization that was observed in a vitamin D-deficiency was probably a result of the lower Ca+2 and/or HPO4-2 concentrations in blood which were also mirrored in …
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The in Vitro Effects of the Sulfate Conjugate of Dehydroepiandrosterone on the Incorporation of Radio Phosphate into the Various Fractions of Mouse Kidney Tissue
… However, in comparison to other ions in the extracellular environment such as sodium, potassium and carbonate, phosphate is relatively scarce. Thus, the organism is faced with the essential task of concentrating phosphate within the cellular structures. In the vertebrate groups this task is …
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Zinc-mediated cell death in the hippocampus following experimental traumatic brain injury
… neuronal damage is a key feature of experimental fluid percussion traumatic brain injury in rodents. However, the mechanisms contributing to the susceptibility to neuronal injury in this region are largely unknown. Since free ionic zinc (Zn2+) was shown to be toxic to neurons in vitro, I sought to …
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Characterization of neural ion regulation dysfunction during insult and evaluation of micro-opioid receptor activation during simulated ischemia in the pre-botzinger complex
… Even slight alterations in intracellular or extracellular can have a devastating effect on excitability and neural vitality. This thesis investigates several concepts related to ion flux. First, it investigates how ion flux affects characterization of brain tissue by dielectric spectroscopy …
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Structure and function of sarcoplasmic reticulum isolated from slowly and from rapidly-glycolysing skeletal muscle
… and ions out of the muscle cell into the extracellular fluid. In addition, the nature of the lipid-ATPase interaction was examined by observing the effect of temperature on the functional activities of the sarcoplasmic reticulum.
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Convective intracellular macromolecule delivery for cell engineering applications
… transient cell volume exchange. Ultrafast microfluidic cell compressions (<1 ms) are used to cause brief, deformation-induced cell volume loss followed by volume recovery through uptake of extracellular fluid. Macromolecules suspended in the surrounding fluid enter the cell on convective fluid …
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New mathematical models of inert gas transport through biological tissue in hyperbaric environments
… this constant and the volume fraction of extracellular fluid. The second embraces a number of current models and is applicable to perfused tissue. It should be useful in interpreting inert gas uptake curves. The model is applied to experimental data, and a source of possible error is …
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Materials for bioimplantable / bioresorbable electronics
… sensors capable of monitoring biomarkers in extracellular fluid, with soft physical form factors to facilitate bio-integration. The next chapters investigate chemical stabilities of thin nanomembranes of silicon and thermally grown silicon dioxide in biofluids for their provisioned importance …
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Diffusion and reactions of nitric oxide, oxygen, and superoxide in cells and culture media
… of macrophages, thereby delivering it to the extracellular fluid at significant rates. The research in this thesis aimed to determine the concentration profiles of NO and related species in cell cultures and tissues. Toward that end, the diffusion and reactions of NO, 02, and 02- were studied …
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Fluid and blood pressure management in maintenance hemodialysis patients
… medications may change due to the removal of extracellular fluid by ultrafiltration and other factors. Because most blood pressure medications are vasodilators or impact other components of cardiovascular function, they may prevent the normal physiological response to changes in volume during …
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Quantitative analysis of the extracellular glutamate concentration of the nucleus accumbens
… was used to sample neurotransmitters from the extracellular fluid of the nucleus accumbens (NAS). Sample concentrations of dopamine and glutamate were assayed using high performance liquid chromatography followed by electrochemical detection. Sample glutamate concentrations decreased and then …
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Biophysical Techniques of Transcutaneous Drug Sampling and Drug Delivery
… estimating the drug concentration in the skin extracellular fluid. The application of ETS technique in studying dermatokinetics of cephalexin, ciprofloxacin, and 8-methoxypsoralen was investigated. The results demonstrated the ability of ETS technique in dermatokinetic studies of drugs with …
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Novel strategies to enhance bumetanide concentrations in the brain in the treatment of neonatal seizures
… in the brain. Bumetanide was detected in brain extracellular fluid and this concentration increased after probenecid administration. An in vivo model of hypoxic-ischaemic neonatal seizures was established to quantify the pharmacodynamic effect of bumetanide in seizures. OAT3 inhibition enhanced …
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Supramolecular architectures for neural prostheses
… can readily be sequestered from the background extracellular fluid. The parameters of using such a stimulation technique are first established by performing in-vitro experiments on rabbit retinas. The results show that modest increases (~~10mM) of K+ ions are sufficient to elicit a neural …
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