Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 193 for “"Extracellular Vesicles"”.
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Characterizing Oxylipins in Human Milk Extracellular Vesicles
<p>Extracellular vesicles (EVs) are non-replicating lipid bilayer membrane-bound particle formed by a parent cell and secreted into the extracellular environment. EVs in human milk are bioavailable and influence physiologic pathways that may contribute to newborn growth and development. There is …
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Manufacturing and engineering of therapeutic extracellular vesicles
… cells release to dispose of unwanted material, extracellular vesicles (EVs) have emerged as potent messengers that package and disseminate biochemical signals. This newly recognized mode of communication between cells has brought unprecedented therapeutic opportunities; at least 8 clinical …
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THE ROLE OF EXTRACELLULAR VESICLES IN HEART DISEASES
Background and Aim: Heart diseases, including hypertrophic cardiomyopathy (HCM) and heart failure (HF), remain among the leading causes of morbidity and mortality worldwide. Epidemiological data indicate that their burden will continue to rise in the coming years, with HF representing an expanding …
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Brain-derived Extracellular vesicles as biomarkers of Parkinson’s disease
… relatively invasive. In contrast, brain-derived extracellular vesicles (EVs) are found to be in substantial concentrations in systemic circulation, allowing for the possibility of a diagnostic blood test. In this study, we demonstrate that a higher concentration of alpha synuclein (aSyn) and …
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Integrated Microfluidic System for Digital Detection of Extracellular Vesicles
Investigating the components of extracellular vesicles (EV) has shown substantial promise for cancer diagnosis. However, detecting them individually and profiling its membranal proteins is still challenging. Isolating EVs individually can help us track their protein expression and to study their …
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Human neutrophils generate extracellular vesicles that modulate their functional responses
… and chemokines, by generating neutrophil extracellular traps (NETs), and by modulating their own survival. Neutrophils also produce extracellular vesicles (EVs) termed ectosomes, which influence the function of other immune cells. Here, we studied neutrophil-derived ectosomes (NDEs) and …
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Identification of surface accessible proteins in parasitic nematode extracellular vesicles
Extracellular vesicles (EVs) are membrane-bound nanoparticles released by the cells of many organisms, containing important biological molecules including bioactive proteins, lipids, and nucleic acids. EVs are shed by parasitic nematodes into the host environment and have been shown to play a …
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Characterization of Free Oxylipins in Extracellular Vesicles from Bovine Milk
<p>Background. Extracellular vesicles (EVs) are membrane-bound nanostructures released by human and bovine mammary epithelial cells that carry bioactive lipids and oxidized lipid metabolites. Found in bovine milk, EVs contribute to immune modulation, gut health, and cellular signaling. However, …
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Extracellular Vesicles as Mediators of Communication Between Endothelial Cells and Fibroblasts
… mode of intracellular communication is through extracellular vesicles (EVs), capable of transferring regulatory molecules such as microRNAs (miRNAs) to nearby or distant cells. This study investigated whether EVs secreted by human dermal microvascular endothelial cells (EC-EVs) influence …
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STRUCTURAL INVESTIGATION OF EXTRACELLULAR VESICLES AND THEIR INTERACTION WITH BIOMIMETIC INTERFACES
Over the last decade, research about extracellular vesicles (EVs), the nanosized membrane bound vesicles, secreted by all kinds of cells to deliver a physiological cargo and their influence on the cell-mediated communication has been rising as a hot topic. Different EVs, have different …
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Analyzing Extracellular Vesicles for Disease Monitoring in Metastatic Colorectal Cancer Patients
… is often limited. Liquid biopsy utilizing extracellular vesicles (EVs) is an alternative approach for obtaining insights into molecular landscapes of mCRC. Cancer-derived EVs play a critical role in cancer cell-to-cell communication and carry surface proteins and cell-specific cargos of …
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The role of RNAs and extracellular vesicles in the radiation response
… more recently it has been demonstrated that extracellular vesicles (EVs) might be involved. In addition, following RNase treatment, the EVs are no longer able to cause DNA damage in unirradiated recipient cells, suggesting that an RNA molecule in association with the EVs is involved with BE. …
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Investigating the role of TRPC3 in the biogenesis of extracellular vesicles
… package and release nano-sized spheres called extracellular vesicles (EVs) that carry an array of biomolecules that can be transferred between cells. EV-mediated communication contributes to a wide range of physiological and pathological processes including cancer progression, yet the molecular …
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