Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Extracellular Matrix Degradation"”.
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Extracellular Matrix Degradation and Mechanical Integrity of Degenerated Human Annulus Fibrosus from Surgical Specimens
… yet the mechanistic link between biochemical matrix degradation and functional mechanical failure of the annulus fibrosus (AF) remains poorly defined in human tissue. The interlamellar matrix (ILM), which binds adjacent collagen lamellae via cross-bridges, is a key determinant of AF mechanical …
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Cracking the code of cathepsin S: Structural determinants of specificity switching
… activates receptors, and is associated with extracellular matrix degradation in autoimmune diseases and cancer. A comprehensive review of the literature revealed potential pH- and redox-dependent specificity switches in the proteolytic specificity of cathepsin S. These were investigated …
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Role of Thrombin-Activatable Fibrinolysis Inhibitor in Breast Cancer Metastasis and Angiogenesis
… process is facilitated by proteases that promote degradation of the extracellular matrix, cell migration and cell invasion. Angiogenesis is important to the metastatic process and also involves extracellular matrix degradation, endothelial cell migration and invasion. Proteases such as plasmin and …
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Targeting the Urokinase Plasminogen Activator System Combined with Chemotherapy-a Potentially Novel Therapeutic Approach for Pancreatic Cancer
… through inhibition of cancer cell proliferation, extracellular matrix degradation, and epithelial-mesenchymal transition (EMT). The combination treatment notably suppressed cancer stemness, a key factor in tumour initiation, recurrence, and resistance. Subsequently, the experiments were replicated …
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Effect of Maternal Hypoxia on the Cerebral and Cardiac Tissue Remodeling
… in the brain of neonatal rats and that unopposed extracellular matrix degradation was likely to contribute to the brain injury and growth restriction observed in the present study. The second part of project focused on the effect of fetal hypoxia on heart development. We demonstrated that maternal …
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Influence of mitochondrial and nuclear genomic dysfunction on lipid homeostasis in lipidemic diseases
… (LBP) and disability. Its pathogenesis involves extracellular matrix degradation and inflammation, augmented by mitochondrial dysfunction and dysregulated lipid metabolism. DDD and dyslipidaemia are both highly prevalent non-communicable diseases (NCDs) in South African urban populations, with …
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Role of the Abelson Tyrosine Kinases in Regulating Macrophage Functions in Immunity and Cancer
… whereas overexpression of Abl kinases enhanced extracellular matrix degradation. We found that partial loss of Abl kinase expression in myeloid cells reduced macrophage infiltration into tumors in a mouse model of breast cancer. Furthermore, pharmacological inhibition of Abl kinases reduced …
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Development of Novel Therapies for Marfan Syndrome using a Human iPSC-disease model
… disorder caused by mutations in fibrillin-1, a matrix component encoded by the gene FBN1, with pleiotropic manifestations including severe cardiovascular complications, such as aortic aneurysms and dissection. Current treatments focus on surgically removing the aneurysm or on minimising aortic …
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Slc39a8/zip8 Influences Complex Traits By Regulating Metal Ion Metabolism
… metalloproteinase transcription, and impaired extracellular matrix degradation that has been implicated in noncompaction. Thus my dissertation reveals the mechanism in which Slc39a8 mediates Mn transport in vivo and demonstrates that Slc39a8 acts through Mn and Zn to modulate the activity of Mn …
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Eph-mediated restriction of cerebrovascular arteriogenesis
… cell (EC) and smooth muscle cell proliferation, extracellular matrix degradation and recruitment of circulating bone marrow-derived cells (4-6). Unlike spouting angiogenesis, which requires weeks following occlusion to develop, arteriogenesis begins as early as 24-48hrs post-stroke (7, 8) and can …
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Biocompatibility and Bioactivity of Calcium Silicate-based Dental Bioceramics
… release of bioactive peptides units produced by extracellular matrix degradation.