Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Extracellular ATP"”.
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The Role of Extracellular ATP in Dictyostelium discoideum Growth and Development
… of the cell. Despite the lack of cell surface ATP receptors, previous studies have indicated the existence of Dictyostelium ecto-ATPases and calcium responses to the addition of exogenous ATP. In these experiments it was found, using the luciferase assay, that the cells condition their media …
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The Role of Arabidopsis thaliana Annexins 1, 2 and 4 in Extracellular ATP Signalling
Extracellular ATP (eATP) is an important signalling molecule in animals but its importance is less understood in plants. Accumulation of eATP in plants occurs in response to biotic and abiotic stresses. eATP causes downstream responses such as increase in cytosolic free calcium …
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The Role of Arabidopsis thaliana Cyclic Nucleotide-Gated Channels 2, 6, and 19 in Extracellular ATP Signalling
… Ca2+ signals (Ca2+ signatures) to translate extracellular signals into cellular responses. Extracellular Adenosine 5’-triphosphate (eATP) is a crucial signalling molecule in plants but poorly understood. Upon abiotic and biotic stresses, ATP is released into the extracellular matrix, where it …
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Identification of an extracellular adenosine 5'-triphosphate receptor in Arabidopsis thaliana
… AT AUTHOR'S REQUEST.] Adenosine 5'-triphosphate (ATP) is a well-known energy currency in all organisms. However, ATP also acts as a signaling molecule when it is secreted outside the cell. The long-term goal of my research is to understand the molecular mechanism of extracellular ATP recognition …
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A novel approach to real-time monitoring of erythrocyte ATP release as a function of hypoxia
… in local vasodilatory signaling by releasing ATP in response to hypoxia. RBC ATP release and overall function are impaired with age and disease. Until now, luciferin/luciferase bioluminescence is the only method described to quantify ATP release from RBCs. Here, we describe a novel approach …
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JAG1 Blockade With oHSV Polarizes Macrophages to Create a Unique Vulnerability for Cetuximab-Mediated Senolysis of Glioma Cells
… chemokines and DAMPs such as IL-1β and extracellular ATP. RNA sequencing of murine macrophages co-cultured with infected human tumor cells showed enrichment of chemotactic and pro-inflammatory pathways as well as increased Fc receptor activation following OncoD-0J1 infection. Single-cell …
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Studies on Macrophage Migration in Pathological Contexts
… development and maintenance of neuropathic pain. ATP is a transporter of chemical energy, but can also act as an extracellular signalling molecule that signals through purinergic receptors. ATP, probably released from damaged neurons, can promote the migration of macrophages and microglia to the …
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ATP, TRP channels and airway neuronal sensitisation
… gaining a deeper understanding of the roles of ATP and transient receptor potential (TRP) channels in chronic cough by working with primary bronchial epithelial cells (PBECS) and an in-Vitro human sensory neuronal model differentiated from human dental pulp stem cells termed peripheral neuronal …
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The relevance of adenylate levels and adenylate converting enzymes on metabolism and development of potato (Solanum tuberosum L.) tubers
… by hydrolyzing the signal mediating molecules ATP and ADP to AMP. This PhD thesis focused on the role of adenylates on metabolism and development of potato (Solanum tuberosum) by using reverse genetics and biochemical approaches. To study the short and long term effect of cellular ATP and the …
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Clinical and Biological Aspects of Cardiovascular microRNA
… endothelial inflammation in response to extracellular ATP/UTP. In Study I and II, we found that cardiac-enriched miRNAs are increased 100-3000 fold within 12 h following onset of symptoms in patients with myocardial infarction and that the levels of two specific miRNAs, miR-208b …
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ADP regulation of insulin secretion and beta-cell apoptosis
… dissertation were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate …
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Mechanisms of Evasion: Anti-Tumor Immune Suppression & TRNA-Dependent Growth in Cancer Metastasis
… cancer cells and can also be released into the extracellular space. This kinase enzymatically consumes extracellular ATP—a potent immune stimulatory Danger Associated Molecular Pattern (DAMP) molecule—from the tumor microenvironment. ATP hydrolysis by CKB generates ADP, an immune suppressive …
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MUTACIN IV PRODUCTION IN STREPTOCOCCUS MUTANS UA159: CHARACTERIZATION, REGULATION, AND MECHANISM OF SELF-IMMUNITY
… production. Highlight of our finding is that an extracellular ATP-independent Lon-like protease functions specifically on maturation of peptide pheromone, CSP. Here, we show that functional form of CSP (18-amino acids) is generated by a specific post export cleavage with this Lon-like protease. …
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Dining in the Dark ATP Sensing in the Female Aedes Aegypti Mosquito
… same neurons respond to a mixture of saline and ATP. However, ATP alone activates only a small subset of 3-7 stylet neurons compared to those activated by blood or saline and ATP. Despite this initial view into what activates feeding using the stylet, the mechanism by which ATP stimulates …