Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 3179 for “"Extracellular"”.
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Neutrophil extracellular traps in periodontitis
… thesis has investigated the role of neutrophil extracellular traps (NETs) in the pathogenesis of periodontitis. A fluorometric assay was developed for the in vitro quantification of NET release and used to assess relative levels in chronic periodontitis patients, indicating elevated release …
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Extracellular Spaces and Cardiac Conduction
Despite decades of research and thousands of studies on cardiac electrophysiology, cardiovascular disease remains among the leading causes of death in the United States today. Despite substantially beneficial advances, we have largely shifted cardiovascular disease from an acute to a chronic issue. …
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Design of Artificial Modular Extracellular Matrices
… are essentially controlled by the surrounding extracellular matrix (ECM). The mechanical, chemical and structural properties of the ECM are consequently crucial for the selection of cells at interfaces and the formation of tissues. The objective of this thesis was to develop an artificial ECM …
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Altering Inhibitory Extracellular Matrix Promotes Remyelination
… sulfate proteoglycans (CSPGs) are a family of extracellular matrix molecules that provide structural rigidity to tissues and act as signalling molecules to neurons and glia in the developing nervous system. After injury, CSPGs become highly upregulated by astrocytes as part of the glial scar …
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Extracellular Interaction Screening Using CRISPR Activation
Extracellular interactions between cell surface receptors are necessary for signaling and adhesion but identifying them remains technically challenging. We describe a cell-based genome-wide approach employing CRISPR activation to identify receptors for a defined ligand. We show receptors for …
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Nanomechanics of cartilage extracellular matrix macromolecules
In this thesis, the shear and self-adhesion nanomechanical properties between opposing cartilage aggrecan macromolecules were probed. In addition, nanoscale dynamic oscillatory mechanical properties of cartilage and its type II collagen network was measured. Aggrecan shear nanomechanics was …
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Extracellular Vesicle Capture and microRNA Detection
… accessible biomarkers via liquid biopsies. Extracellular vesicles have shown promise as a noninvasive biomarker for disease diagnosis and monitoring, and have become a treasure trove of information because they have been found to carry proteins, DNA, mRNA and microRNA as well surface markers …
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Lake Benthic Algal Production and Extracellular Material
… its importance to the lake as a whole. Benthic extracellular material, shown to be important for food web dynamics and stabilization of the surrounding ecosystem in the marine intertidal, is even less frequently studied in lakes. I examined the environmental and community level drivers of …
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An extracellular protease from an extreme thermophile
The major extracellular protease of the Thermus-like organism Thermus T-351, has been isolated by Sephadex SP-C25 ion exchange chromatography, affinity chromatography on CBZ-D-phe-TETA-Sepharose and Sephadex G75 gel filtration chromatography. The purified enzyme, assigned the title “Caldolysin”, …
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Plasma Extracellular Vessicles, Exercise Resistnace and Cancer
Extracellular vesicles (EVs) are released into blood from multiple organs and carry molecular cargo that facilitates inter-organ communication and an integrated response to physiological and pathological stimuli. Interrogation of the protein cargo of EVs is currently limited by the absence of …
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Extracellular Signalling and Stem Cell Self-Renewal
In preimplantation mouse embryos, signalling and gene regulatory networks cooperate to determine lineage segregation, and modulating signalling in vitro allows for stem cell populations to be established from these lineages. Fibroblast growth factor (FGF) signalling triggers the differentiation of …
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Characterising the Drosophila extracellular superoxide Dismutase gene
… mammalian (sod3) and C. elegans (sod-4) extracellular sod, was<br/>identified in Drosophila and is also predicted to locate extracellularly (sod3). To date,<br/>no (published) work has been carried out to assess the role of sod3 within insects. This<br/>thesis reports the molecular and …
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Extracellular Metabolic Energetics Can Promote Cancer Progression
… describe CKB-mediated modulation of intra- and extracellular energetics by colon cancer cells that contributed to colon cancer cell survival in the liver microenvironment, allowing for development of macrometastases and finally liver colonization. Further investigation identified the membrane …
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Extracellular Superoxide Dismutase Protects Cardiomyocytes During Hyperoxia
… study was done in mice with a transgene (TG) for extracellular superoxide dismutase (EC-SOD) or with the EC-SOD gene knockout (KO). Adult EC-SOD mice and their wild type littermates and EC-SOD KO mice and their wild type littermates were exposed to 100% oxygen for 6 hours and for 72 hours, and the …
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Preterm intraventricular haemorrhage - Effects of extracellular haemoglobin
Intraventricular haemorrhage (IVH) is the most common brain lesion in preterm infants and is most commonly seen in the sickest children, with 15-20% of very preterm infants developing IVH. The mortality of infants with severe IVH is 20-50 % in the neonatal period and over 50 % of surviving infants …
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Characterizing Oxylipins in Human Milk Extracellular Vesicles
<p>Extracellular vesicles (EVs) are non-replicating lipid bilayer membrane-bound particle formed by a parent cell and secreted into the extracellular environment. EVs in human milk are bioavailable and influence physiologic pathways that may contribute to newborn growth and development. There is …
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