Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Extinction Learning"”.
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Effects of augmentation agents on emotional memory consolidation and subliminal cue exposure to fear-relavent stimuli
… of d-cycloserine (DCS) in rats enhances extinction learning of fear. This research catalyzed further investigation of cognitive enhancers in preclinical and clinical populations, offering support for a beneficial effect of these agents on exposure-based learning. However, the exact …
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Sleep and exposure therapy in adults with social anxiety disorder
… initial therapy success. Deficits in therapeutic learning may explain why some individuals derive little or no benefit from exposure-based therapy. Sleep is one potential mechanism that contributes to therapeutic learning deficits. Poor sleep has been found to impair learning and memory processes …
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Endocannabinoid Modulation of Spatial Memory in Aversively and Appetitively Motivated Barnes Maze Tasks
… of the CB1 receptor has been reported to impair extinction learning in aversive conditioning (i.e., conditioned fear and Morris water maze) paradigms, but not in operant procedures in which food reinforcement is earned. It is difficult to discern whether the differential effects caused by CB1 …
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The Effect of Typical and Atypical Antipsychotics on the MK-801 Induced Deficit in Behavioural Inhibition
… in behavioral inhibition measured as the lack of extinction during operant procedures. As such, MK-801 has the potential to be used as a preclinical animal model of cognitive deficits that arise in schizophrenia. The present thesis sought to explore if typical and/or atypical antipsychotics have …
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Infusion of oxytocin into the basolateral amygdala facilitates, whereas infusion into the central nucleus impairs extinction of context conditioned fear responses in rats
… and BLA infusions of OT on the acquisition and extinction of context conditioned fear responses. In two experiments investigating the effects of OT on fear acquisition, rats were trained to fear a context under a drug infusion and their retention of fear assessed when drug-free. Intra-CeA and …
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Synaptic Control of Dopamine as a Driver of Reward Learning
… to be responsible for driving associative learning, yet interrogating this causality, and understanding how these firing patterns are synaptically created within endogenous neural circuits, has been technically difficult. Utilizing a novel tool, DART (drug acutely restricted by tethering), …
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Motivational State-Dependent Renewal of Operant Responding under Food and Water Deprivation States
… which operant responding may recover following extinction. These and other forms of recovery following extinction have been described as relapse phenomena and demonstrate the context-specific nature of extinction learning. Most studies of relapse phenomena have utilized distinct exteroceptive …
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Dopaminergic modulation of basolateral amygdala for fear extinction
The extinction of conditioned fear responses is crucial for adaptive behavior, and its impairment is a hallmark of anxiety disorders such as post-traumatic stress disorder. During fear extinction learning, a new memory is formed in basolateral amygdala (BLA) reward neurons, which inhibits the BLA …
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The Neural Substrates Supporting the Inhibition of Instrumental Avoidance Behavior
… stimulus (CS+) predictive of a foot shock while learning to avoid another stimulus (CS-) not followed by shock. However, less is know about the neural substrates involved in the inhibition of this behavior, as occurs when a stimulus acquires inhibitory properties and signals response omission. …
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A psychological analysis of the effects of memory retrieval prior to extinction on the reacquisition of a conditioned fear association
… of the fear-inducing stimulus one hour prior to extinction training. This procedure produces extinction learning that is resistant to the return of fear resulting from a change of context, the passage of time, exposure to the unconditioned stimulus, and even further conditioning of the stimulus …
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Investigating the role of extrasynaptic GABAA receptors located in the infralimbic cortex in the binge-like alcohol intake of male C57BL/6J mice
… exposure has been shown to interfere with extinction learning; impairments of which may be related to inflexible behavior (i.e. problematic alcohol consumption). Adult male B6 mice were bilaterally implanted with stainless steel guide cannulae aimed at the ILC and were offered limited …
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The Impact of Brief Mindfulness Interventions on Attentional Control in Anxious Undergraduates: A Randomized Controlled Study
… in individuals with anxiety yet necessary for extinction learning in treatment. In theory, mindfulness interventions can facilitate increased attentional control during exposure tasks, thereby enhancing new learning and eventually improving treatment outcomes. Using a randomized controlled …
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Antidepressant-Like Effects of Ketamine on Fear Conditioning and Extinction
… studied in animals using fear conditioning and extinction paradigms. Fear conditioning trains an animal to associate a neutral cue with an emotionally aversive experience, while extinction learning challenges this association by forming a new memory that identifies the cue as harmless. The aim …
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Efficacy of an Integrated Sleep and Anxiety Intervention for Anxious Children: A Pilot Randomized Controlled Trial
… outcomes given the role of sleep in facilitating extinction learning. Thus, addressing sleep as part of anxiety-focused interventions may produce superior outcomes in terms of both anxiety and sleep. Although three studies have shown purely anxiety-focused interventions improve sleep-related …
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Serotonin Modulates the Maturation of the Medial Prefrontal Cortex and Hippocampus: Relevance to the Etiology of Emotional and Cognitive Behaviors
… of PN-FLX mice to extinguish learned fear ("fear extinction"), as performance in this behavioral paradigm is modulated by IL/PL output. Congruent with their altered IL/PL balance, PN-FLX mice display deficits in fear extinction learning and recall. Mimicking the diminished IL/PL ratio by …