Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Extensively-drug resistant TB"”.
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The relationship between chest X-ray findings, bacterial load and treatment-related outcomes in persons with extensively drug resistant TB
Multi-drug resistant tuberculosis (MDR-TB) was first recognized in the 1990s with an increase in caseload of eighty-two percent between 2000 and 2007. Extensively drug-resistant tuberculosis (XDR-TB), a more difficult and more expensive form of TB to treat with poorer outcomes, emerged in South …
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Prevalence of drug-resistant tuberculosis and associated risk factors among patients in the Northern Region of South Africa
Background: Drug-resistant TB is a major global health threat, driving the ongoing TB epidemic and increasing morbidity and mortality worldwide. Currently, national tuberculosis (TB) control programmes are challenged by the emergence of drug resistance to more anti-TB drugs resulting in multi-drug …
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Synthesis, structure-activity relationship and solubility profiling of antimycobacterial aminoquinazolinones
Tuberculosis (TB) is a communicable disease caused by an infectious bacterial pathogen called Mycobacterium tuberculosis (Mtb), which is acquired through the inhalation of bacilli-containing droplets. With the emergence of resistant strains (multidrug-resistant TB (MDR-TB), extensively …
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Development and in vivo Analysis of Inhaled Clofazimine for the Treatment of Pulmonary Tuberculosis
Tuberculosis (TB) is a leading cause of death globally, despite current treatment options. The old and rarely used oral antibiotic, clofazimine (CFZ), is a potentially viable treatment option against TB infections due to its activity against TB, multidrug-resistant TB (MDR), and extensively …
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Microbiological, genomic and transcriptomic analyses of human tuberculosis lung cavities
BACKGROUND: Tuberculosis (TB) remains out of control globally. Recent promising vaccine candidates have failed in clinical trials and host immunity in the lung remains poorly understood. Pathogenesis of pulmonary cavitation, the basis of TB transmission, is poorly understood. The degree of …
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Design, Synthesis, and Evaluation of Novel Antimycobacterial Agents With Enhanced Pharmacokinetic Profiles
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb), is one of the leading causes of death worldwide. The present short-course therapy is six months long for drug-susceptible M. tb strains, and up to two years for multi-drug-resistant TB (MDR-TB) and extensively drug-resistant TB …
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Linkage to treatment following RR-TB diagnosis in the Western Cape
Patients diagnosed with rifampicin resistant (RR) tuberculosis (TB) in South Africa frequently fail to link to appropriate drug resistant (DR) TB treatment. The aim of this study was to explore barriers and enablers to expedited linkage to treatment following RR-TB diagnosis in the Western Cape …